MyMedR

Fulltext Extraskeletal osteosarcoma of the thigh

Dhillon KS, Suntharalingam S, Maurer HJ

Med J Malaysia, 1993 Dec;48(4):453-6.

To our knowledge extraosseous osteosarcoma has not been reported in the Malaysian literature. We report a case of extraosseous osteosarcoma which was treated by intra-arterial chemotherapy, embolization, wide resection of tumour and salvage of limb with good functional result.

Matched MeSH terms: Osteosarcoma/pathology; Osteosarcoma/therapy*

Fulltext Osteosarcoma in a sixteen-month old boy

Ibrahim S, Sundari MN, Masir N

Med J Malaysia, 1999 Jun;54(2):261-3.

PMID: 10972039

We report a case of a sixteen-month old boy with osteosarcoma of the left humerus. To the best of our knowledge this is the youngest case reported in Malaysia. This case illustrates that osteosarcoma although rare does occur in a very young child. The child died six weeks after presentation due to disseminated disease.

Matched MeSH terms: Osteosarcoma/diagnosis*; Osteosarcoma/pathology

Two diseases in the same patient

CHIA M

Med J Malaya, 1957 Mar;11(3):247-9.

PMID: 13477003

Matched MeSH terms: Osteosarcoma*

Fulltext An extensive sinonasal osteosarcoma mimicking chondrosarcoma

Shahid H, Baharudin A, Halim AS, Biswal BM, Jihan WS

Med J Malaysia, 2007 Jun;62(2):171-2.

PMID: 18705458 MyJurnal

Osteosarcoma is a rare tumour in the sinonasal region. Early diagnosis is essential for adequate management and better prognosis and this requires a meticulous histopathological examination. Reported is a case of osteosarcoma misdiagnosed as chondrosarcoma and treated by surgery followed by radiotherapy. However, appropriate diagnosis and pre-operative chemotherapy would have been significant in the prognosis. The pitfall of accurate diagnosis and the subsequent treatment is discussed in order to find the ways to maximize five years survival which is not more than 25% in this type of lesions.

Matched MeSH terms: Osteosarcoma/diagnosis*; Osteosarcoma/pathology; Osteosarcoma/therapy

Fulltext A case of osteosarcoma of the maxilla - challenges in diagnosis and management

Abdul Rahim, N.I.H., Ngah, N.A., Ramanathan, A., George, T., Ismail, S.M.

Ann Dent, 2011;18(1):24-29.

MyJurnal

Osteosarcoma is a primary malignant neoplasm of the bone. Osteosarcoma of the jaws especially those of maxilla is rare. The diagnosis of osteosarcomas is difficult and challenging. In this case report we highlight a rare case of osteosarcoma of the maxilla in a 29 year old male patient which was highly aggressive and was initially diagnosed as rhabdomyosarcoma. This case highlights the difficulty in diagnosing osteosarcoma merely from incisional biopsy specimens which may not be representative of the whole tumour. Limited clinical information at incisional biopsy also adds to the difficulty in arriving at the definitive diagnosis. We further discuss the treatment modalities followed in this case.

Matched MeSH terms: Osteosarcoma

Lumbosacral osteosarcoma with dural spread, skip lesions and intravascular extension: A case report

Noor Khairiah AK, Mohamad Nazrulhisham MN, John G

Med J Malaysia, 2018 04;73(2):116-118.

PMID: 29703878 MyJurnal

Primary osteosarcoma of the spine is indeed rare and only several sporadic cases have been reported. It tends to occur in a slightly older age group than those with appendicular skeleton tumours. We present here an unusual case of aggressive lumbosacral osteosarcoma in a young teenager complicated by extensive dural spread, skip lesions and intravascular extension. Although a histopathological examination is mandatory to establish the diagnosis, this case emphasises the need of imaging to ascertain the full extent of disease spread especially in deciding the type of treatment to be instituted and to evaluate the response to the treatment.

Matched MeSH terms: Osteosarcoma

Photodynamic application of protoporphyrin IX as a photosensitizer encapsulated by silica nanoparticles

Makhadmeh GN, Abdul Aziz A

Artif Cells Nanomed Biotechnol, 2018;46(sup3):S1043-S1046.

PMID: 30449196 DOI: 10.1080/21691401.2018.1528982

BACKGROUND: Achieved Silica Nanoparticles (SiNPs) to encapsulate the photosensitizer [Protoporphyrin IX (PpIX)] in photodynamic therapy (PDT) application was reported in this research.

MATERIALS AND METHODS: Cytotoxicity for five different concentrations of encapsulated and naked PpIX was measured. Optimum concentration and optimum exposure time of encapsulated and naked PpIX that needed to destroy the cells (Osteosarcoma cells) was measured.

RESULTS: The results showed that the encapsulated PpIX has more efficacy compared to the naked PpIX and the applicability of the encapsulated PpIX-SiNPs was proved on osteosarcoma cells.

CONCLUSION: The results established the important in-vitro photodynamic effectiveness of PpIX-SiNP, which may open a new application for PpIX in its clinical and in-vitro studies.

Matched MeSH terms: Osteosarcoma/drug therapy*; Osteosarcoma/metabolism; Osteosarcoma/pathology

Fulltext Modular endoprosthetic replacement after total femur resection for malignant bone tumor

Faisham WI, Zulmi W, Halim AS

Med J Malaysia, 2005 Jul;60 Suppl C:45-8.

PMID: 16381283

Total femur endoprothesis is an alternative replacement for massive malignant bone tumor with intramedullary extension or skip lesion. Four patients underwent total femoral resection and replacement with megaprosthesis: three had primary malignant bone tumor and one had salvage procedure for aseptic loosening of the distal femoral replacement. Tumor-free margins were achieved in all patients with two patients required vascularized latissimus dorsi free flap cover for reconstruction of soft tissue defects. The average follow-up was 24 months (range 16 - 60 months). All four patients were still alive with three of them being disease-free and one survived even with the presence of lung metastasis. The functional results obtained were either excellent or good in all patients in accordance to the Musculoskeletal Tumors Society grading system.

Matched MeSH terms: Osteosarcoma/surgery*

Fulltext Limb salvage in osteosarcoma using autoclaved tumor-bearing bone

Pan KL, Chan WH, Ong GB, Premsenthil S, Zulkarnaen M, Norlida D, et al.

World J Surg Oncol, 2012;10:105.

PMID: 22681750 DOI: 10.1186/1477-7819-10-105

Tumor prostheses currently give the best short- and medium-term results for limb-salvage reconstruction procedures in the treatment of bone tumors. However, in developing countries, the cost of a tumor prosthesis is beyond the reach of much of the population. We report the use of autoclaved tumor-bearing bone in 10 patients, as an affordable alternative to the use of prostheses.

Matched MeSH terms: Osteosarcoma/radiography; Osteosarcoma/rehabilitation; Osteosarcoma/surgery*

Endoprosthetic reconstruction for giant cell tumors of the distal tibia: a short term review

Ajit Singh V, Nasirudin N, Bernatt M

Asia Pac J Clin Oncol, 2013 Jun;9(2):182-9.

PMID: 22897856 DOI: 10.1111/j.1743-7563.2012.01553.x

Custom-made endoprosthetic reconstruction for distal tibia tumors is a viable option of treatment in carefully selected patients. It maintains satisfactory function and provides good pain relief. We report four cases of giant cell tumors of the distal tibia successfully treated by endoprosthetic reconstruction. This is a feasible option in cases of this nature and offers a better function than the other available options.

Matched MeSH terms: Osteosarcoma/pathology; Osteosarcoma/radiography; Osteosarcoma/surgery*

Initial symptoms and delayed diagnosis of osteosarcoma around the knee joint

Pan KL, Chan WH, Chia YY

J Orthop Surg (Hong Kong), 2010 Apr;18(1):55-7.

PMID: 20427835

To identify initial symptoms of osteosarcoma around the knee joint.

Matched MeSH terms: Osteosarcoma/complications*; Osteosarcoma/diagnosis*; Osteosarcoma/therapy

Fulltext Osteosarcoma: the outcome of limb salvage surgery

Faisham WI, Zulmi W, Halim AS, Biswal BM, Mutum SS

Med J Malaysia, 2004 Dec;59 Suppl F:24-34.

PMID: 15941157

We reviewed the surgical and oncological management 23 consecutive patients with osteosarcoma of the long bones to determine the outcome of limb salvage technique performed in our centre. All patients received neoadjuvant chemotherapy. There were 15 males and 8 females with a mean age at diagnosis of 19 years (9 to 36). The median follow-up was 30 months (10 to 60). Fifteen had lesion around the knee joint followed by three in the proximal humerus, two in distal humerus, two in the pelvis, and one in the distal tibia. Six patients presented with lung metastases at diagnosis. We performed limb salvage surgery to control local disease in 16 patients and amputation in 7. The resection margins of the primary lesion were adequate and free of tumour cells in all patients. Local recurrence developed in 1 patient of limb salvage group. The overall median survival was 22 months and actuarial survival was 52% at 3 years. Eleven patients died of pulmonary metastases within 2 years of follow-up. Median survival of the limb salvage surgery group was 30 months compared to 6 months in the amputation group. As per our experience, limb salvage technique is a feasible option in extremity osteosarcoma without compromising survival.

Matched MeSH terms: Osteosarcoma/diagnosis; Osteosarcoma/drug therapy; Osteosarcoma/surgery*

Fulltext The Incidence of Malignant Infiltration in the Biopsy Tract of Osteosarcoma

Mohana, R., Faisham, W.I., Zulmi, W., Nawfar, A.S., Effat, O., alzihan M.S.

Malays Orthop J, 2007;1(2):7-10.

MyJurnal

Biopsy is a crucial step in the management of musculoskeletal sarcoma. The surgical approach to the biopsy site is important, as the tract must be removed en bloc with the tumour during limb sparing surgery so as to reduce the risk of local recurrence. The biopsy tracts of 26 osteosarcoma patients were evaluated histologically for tumour infiltration. Horizontal sections of 1 mm thickness with 2 cm radius from were evaluated from each excised biopsy tract. Five out of 26 cases (19.2%) showed positive tumour infiltration. One case (3.85%) had tumour infiltration in the pseudocapsule, two cases (7.69%) had tumour infiltration into the muscle and two other cases (7.69%) had tumour infiltration into the subcutaneous tissue. None had skin infiltration. We conclude that resection of the entire biopsy tract is indeed mandatory for surgical treatment of osteosarcoma.

Matched MeSH terms: Osteosarcoma

Fulltext A retrospective clinicopathological study of 59 osteogenic sarcoma of jaw bone archived in a stomatology unit

Ajura AJ, Lau SH

Malays J Pathol, 2010 Jun;32(1):27-34.

PMID: 20614723 MyJurnal

To determine the clinicopathological features of osteogenic sarcomas of the mandible and maxilla.

Matched MeSH terms: Osteosarcoma/epidemiology*; Osteosarcoma/pathology*

Fulltext Moulded cement-prosthesis for osteosarcoma of the proximal humerus

Pan KL, Ong GB, Potukuchi AP

Med J Malaysia, 2006 Dec;61 Suppl B:55-7.

PMID: 17600994

We report a case of an 11-year-old boy with osteosarcoma of the proximal humerus treated with wide excision and reconstruction with a cement spacer-prosthesis. After seven years of follow-up, the patient is now almost a young adult. We present his current physical and functional status, which seems to defray the initial doubts regarding long-term problems when we chose this method of reconstruction.

Matched MeSH terms: Osteosarcoma/radiography; Osteosarcoma/surgery*

Prognostic factors and survival rate of osteosarcoma: A single-institution study

Faisham WI, Mat Saad AZ, Alsaigh LN, Nor Azman MZ, Kamarul Imran M, Biswal BM, et al.

Asia Pac J Clin Oncol, 2017 Apr;13(2):e104-e110.

PMID: 25870979 DOI: 10.1111/ajco.12346

AIM: Osteosarcoma is a highly malignant primary bone tumor. The study aim to evaluate the prognostic factors influencing the survival rate in our center.

METHODS: This was a retrospective cohort study of all patients treated between January 2005 and December 2010.

RESULTS: We included 163 patients with an age range of 6-59 years (median = 19). The median follow-up was 47 months (range 36-84). The overall survival in patients who completed chemotherapy and surgery (n = 117) was 72% at 2 years and 44% at 5 years. Histologically, 99 (85%) had osteoblastic, 6 (5%) had chondroblastic and 3 (2.5%) had telangiectatic osteosarcoma. Limb salvage surgery was performed in 80 (49%) and 41 (25%) underwent amputation. However, 46 patients (28%) underwent no surgical intervention and incomplete chemotherapy. In total, 38/79 patients had a good chemotherapy response. There was a significantly better survival rate for limb salvage versus amputation. Independent prognostic factors for survival are compliance to treatment and presence of lung metastasis.

CONCLUSION: The overall survival of osteosarcoma patients was influenced by the presence of pulmonary metastases and compliance to treatment. Histological subtype, different chemotherapy regimens and histological necrosis after chemotherapy did not significantly influence survival. The patients who did not complete treatment had significantly poorer survival.

Matched MeSH terms: Osteosarcoma/mortality*; Osteosarcoma/pathology

Metastatic osteosarcoma of the ethmoid: an unusual cause of recurrent epistaxis and proptosis

Sharma HS, Reddy SC, Mohamad A, Kamal MZ, Halder D

J Laryngol Otol, 1996 Jul;110(7):676-8.

PMID: 8759546

Osteosarcoma is the most common primary malignant tumour of bone and it usually metastasises to the lung. In the nasal cavity metastatic disease is extremely rare. We describe a case of osteosarcoma presenting with recurrent epistaxis, and proptosis due to secondaries in the nasal cavity. To our knowledge such a case has not been reported previously in the available English literature.

Matched MeSH terms: Osteosarcoma/complications; Osteosarcoma/secondary*

A review of cases of osteosarcoma admitted to the University Hospital Kuala Lumpur

Silva JF, Sin TW

Med J Malaysia, 1978 Mar;32(3):225-31.

PMID: 277747

Matched MeSH terms: Osteosarcoma/epidemiology*; Osteosarcoma/therapy

An epidemiologic study of osteogenic sarcoma in Malaysia. Incidence in urban as compared with rural environments and in each of three separate racial groups, 1969-1972

Silva JF, Subramanian N

Clin Orthop Relat Res, 1975 Nov-Dec;?(113):119-27.

PMID: 1059509

To explore the possibility that environmental and/or genetic factors may yield clues to the etiology of osteogenic sarcoma, an epidemiologic retrospective study of all cases of osteogenic sarcoma in a country with clear geographic and racial variables (Malaysia) was conducted covering a 4-year period. Sixty-eight cases were identified (+85% of the predicted total). The incidence (cases per 100,000 population per year) was 0.11 in Malay, 0.23 in the Chinese, and 0.23 in the Indian. The urban versus rural incidence in the Malay was 0.22 versus 0.09, and in the Chinese 0.31 versus 0.18. The Indian population was too small when dividied into urban and rural segments to be significant.

Matched MeSH terms: Osteosarcoma/mortality; Osteosarcoma/epidemiology*

Fulltext Rare occurrence of bilateral breast and peritoneal metastases from osteogenic sarcoma

Chan RS, Kumar G, Vijayananthan AA

Singapore Med J, 2013 Mar;54(3):e68-71.

PMID: 23546040

Breast metastases are uncommon and typically spread from contralateral breast carcinomas. Breast metastases that spread from extramammary malignancies are even less common, and account for 0.5%-6.6% of all malignant breast disease. As extrapulmonary metastases from osteosarcoma are uncommon, breast metastasis from osteosarcoma is extremely rare. We report a case of breast and peritoneal metastases from a tibial osteosarcoma 18 months after diagnosis, and 9 months after surgery and adjuvant chemotherapy. Computed tomography findings of multiple calcified and noncalcified tumour deposits in the lungs, pleura, peritoneum, chest wall and both breasts are described.

Matched MeSH terms: Osteosarcoma/diagnosis*; Osteosarcoma/pathology*

Displaying publications 1 - 20 of 62 in total