MyMedR

Fulltext Massive lingual teratoma in a neonate

Hassan S, Sidek DS, Shah Jihan WD, Phutane G, Mutum SS

Singapore Med J, 2007 Aug;48(8):e212-4.

Teratoma of the tongue is a rare entity. We present a male newborn with massive lingual teratoma and cleft palate, which surprisingly did not cause immediate airway obstruction. This case illustrates a huge mass in the oral cavity, which was missed on antenatal ultrasonography because it did not present with polyhydramnios. The mass was excised under general anaesthesia. Histopathologically, it consisted of all three layers of embryonic elements with predominantly glial tissue. Postoperatively, the patient developed hypoglossal nerve palsy, and no recurrence was detected after four years.

Matched MeSH terms: Tongue Neoplasms/pathology*; Tongue Neoplasms/surgery

Choristoma of the base of the tongue

Naik VR, Wan Faiziah WA, Musa MY

Indian J Pathol Microbiol, 2009 1 13;52(1):86-7.

PMID: 19136792

Choristoma is a benign tumor where new bone formation occurs. It occurs exclusively in the flat bones of the skull and face. These are slow growing lesions that are usually completely asymptomatic and only present when there is a disruption in the function of the organ due to its large size as it grows. These choristomas can rarely occur in soft tissues especially in the head, eye, tongue, or extremities. Choristomas of the soft tissues are very rare. Only 61 cases of choristomas of the tongue have been reported in literature. Here we report a case of choristoma in the base of the tongue in a 25-year-old Malay female.

Matched MeSH terms: Tongue Neoplasms/diagnosis*; Tongue Neoplasms/pathology*; Tongue Neoplasms/surgery

Fulltext Lymphangioma of the Dorsal Tongue

Nelson BL, Bischoff EL, Nathan A, Ma L

Head Neck Pathol, 2020 Jun;14(2):512-515.

PMID: 31823215 DOI: 10.1007/s12105-019-01108-z

Lymphangiomas are rare, congenital malformations of the lymphatic system which have a marked predilection for the head and neck. In this region, they most commonly occur on the dorsum of the tongue, followed by the lips, buccal mucosa, soft palate, and floor of the mouth. Lymphangiomas of the tongue are commonly present at birth; however, they may go unnoticed until after eruption of the dentition or even puberty. They may present as a defined mass or as macroglossia with impaired speech, difficulty in mastication, and, in extreme cases, airway obstruction. Clinically, lymphagiomas of the tongue are characterized by clusters of pebbly, vesicle-like nodules. A benign proliferation of lymphatic vessels is identified histologically. A classic case of a lymphangioma of the dorsal tongue is presented.

Matched MeSH terms: Tongue Neoplasms/pathology*

Fulltext Recurrent glossal leiomyoma

Idayu MY, Irfan M, Othman NH

Med J Malaysia, 2012 Jun;67(3):329-30.

PMID: 23082428 MyJurnal

Oral leiomyomas are rare benign tumour of smooth muscle. The first case of oral leiomyoma was reported by Blanc in 1884 and since then more cases has been published following advancement in immunohistochemical study. This tumour has an excellent prognosis and recurrences are extremely rare. We report a case of a recurrent glossal leiomyoma in a patient with HIV infection and the lesion recurred one year after the first excision.

Matched MeSH terms: Tongue Neoplasms/pathology; Tongue Neoplasms/surgery*

Fulltext An unusual presentation of lymphoma of the head and neck region

Teh CS, Chong SY

Med J Malaysia, 2011 Aug;66(3):264-5.

PMID: 22111456 MyJurnal

A 33-year-old Malay lady presented to us with 1-month history of globus sensation in the throat. Clinically, she had a 3cmx2cmx1cm sessile soft mass arising from the right tongue base and was treated as hypertrophied lingual tonsil. Biopsy of the mass was done when the patient developed bleeding and was reported as diffuse non-Hodgkin's B-cell lymphoma. Globus sensation is a common complaint in the ORL clinic. It is important to be able to decide if further investigation is warranted to differentiate a malignant from a benign lesion as at times, a malignant lesion can masquerade as a harmless lesion.

Matched MeSH terms: Tongue Neoplasms/diagnosis*; Tongue Neoplasms/therapy

Schwannoma of the tongue in a ten-year old child

Husain S, Husain S, Yunus MR, Yunus MR, Ramli R, Ramli R, et al.

J Pak Med Assoc, 2011 May;61(5):500-1.

PMID: 22204190

The case of a 10-year-old girl is presented who had a slow-growing, painless swelling on the left side of the tongue since six months. This was associated with disturbances in mastication and phonation. Examination revealed a 5 cm x 4 cm. globular smooth, mobile mass on left side of the tongue. There was no neurological deficit and no neck nodes palpable. She underwent excision of the mass under general anaesthesia. Complete enucleation with primary closure was carried out. The patient had an uneventful postoperative recovery and histological evaluation was consistent with schwannoma. The patient was recurrence free after one year.

Matched MeSH terms: Tongue Neoplasms/pathology; Tongue Neoplasms/surgery*

Fulltext Globus sensation in throat, the lymphoid and non-lymphoid origin of tongue base lesions

Irfan M

Med J Malaysia, 2011 Dec;66(5):525.

PMID: 22390121

Matched MeSH terms: Tongue Neoplasms/diagnosis*

Fulltext Suprahyoid pharyngotomy for base of tongue carcinoma

Gopalan KN, Primuharsa Putra SHA, Kenali MS

Med J Malaysia, 2003 Oct;58(4):617-20.

PMID: 15190642

Carcinoma of the tongue remain one of the greatest management challenges for the head and neck surgeon because of the adverse effects of treatment on oral and pharyngeal function. In early carcinoma of the base of tongue however, the prognosis is encouraging and function of swallowing and speech is preserved despite surgery. Suprahyoid pharyngotomy is one of the surgical approaches advocated for resection of base of tongue tumours with primary anastomosis.

Matched MeSH terms: Tongue Neoplasms/surgery*

Fulltext Atypical neurilemmomas of the tongue--report of two cases.

Siar CH, Ng KH, Chia TY, Kulkarni MG

Singapore Med J, 1988 Feb;29(1):83-5.

PMID: 3406779

The aetiology, clinical and histological features of neurilemmomas of the oral and paraoral regions are briefly outlined. Two cases of atypical neurilemmomas of the tongue are described with an intent to document the partial encapsulation and multilobular distribution of the neurogenic tissue noted in these two lesions.

Matched MeSH terms: Tongue Neoplasms/pathology

Fulltext Harmonic scalpel for a bloodless partial glossectomy: a case report

Irfan M, Aliyu YA, Baharudin A, Shahid H

Med J Malaysia, 2011 Jun;66(2):148-9.

PMID: 22106699

Tongue surgery is almost always complicated by intraoperative bleeding. Its rich blood supply especially from the lingual vessels makes the operative field bloody. Electrocautery has been widely used to replace cold scissors in order to achieve better hemostasis. The use of ultrasonic harmonic scalpel for glossectomy is still new in this country. We report a case of partial glossectomy using the harmonic scalpel in a patient who had a squamous cell carcinoma of the lateral border of the tongue.

Matched MeSH terms: Tongue Neoplasms/complications; Tongue Neoplasms/pathology; Tongue Neoplasms/surgery*

Fulltext Vertical Partial Laryngectomy For Glottic Cancer; Report Of Three Cases.

Ahmad, R., Ishlah, W., Norie A.

International Medical Journal Malaysia, 2006;5(2):1-5.

MyJurnal

The ultimate goal of treatment of glottic malignancy is eradication of the cancer and preservation of maximum function. Ideally this would mean return of normal speech, respiration and deglutition. The foundation of vertical partial laryngectomy (VPL) is based on the knowledge of laryngeal anatomy and an understanding of how cancers invade the larynx. The VPL surgery of the glottic cancer is based on oncological sound principles, which will be further disscussed in this article. For the purpose of description we briefly presented 3 of our cases that underwent vertical partial laryngectomy for glottic cancer.

Matched MeSH terms: Tongue Neoplasms

Fulltext Congenital tongue base lipoblastoma causing neonatal airway compromise

Wan MH, Tengku Nun Ahmad TE, Naicker MS, Abu Bakar MZ

BMJ Case Rep, 2021 Jan 18;14(1).

PMID: 33462056 DOI: 10.1136/bcr-2020-239554

Lipoblastomas are benign tumours of immature fat cells presenting in infancy. A lipoblastoma within the airway lumen causing airway compromise is an extremely rare occurrence. We present a 6 hours of life girl who had airway compromise due to a lobulated mass at the base of the tongue. The mass was excised after emergency endotracheal intubation.

Matched MeSH terms: Tongue Neoplasms/complications*; Tongue Neoplasms/diagnosis*; Tongue Neoplasms/surgery

High-grade malignant mucoepidermoid tumour of tongue. A case report

Ng KH, Siar CH

Singapore Dent J, 1989 Dec;14(1):42-5.

PMID: 2487475

Mucoepidermoid tumours of the minor salivary glands of the tongue are rarely encountered. A case of a high-grade malignant type is reported here. Merits of subdivision of the mucoepidermoid tumour on the basis of its malignant potential are outlined, and variations of histological presentation of the present tumour at its primary and nodal sites are discussed.

Matched MeSH terms: Tongue Neoplasms/pathology*

Fulltext Lingual thyroid--a lesson to learn

Ramzisham ARM, Somasundaram S, Nasir ZM

Med J Malaysia, 2004 Oct;59(4):533-4.

PMID: 15779588

We present a case of a middle-aged woman with a mass in the posterior third of the tongue which was diagnosed as a tongue haemangioma. The tumour was successfully excised via a midline mandibular osteotomy and tongue splitting approach. The histopathology examination, however, revealed the 5x4 cms mass to be a lingual thyroid. The salient features of this unusual presentation of a thyroid enlargement will be discussed.
Comment in: Ng CS, Mohd MS. Lingual thyroid--a lesson to learn. Med J Malaysia. 2005
Mar;60(1):115

Matched MeSH terms: Tongue Neoplasms/diagnosis

Fulltext Cystic hygroma: anaesthetic considerations and review

Sharma S, Aminuldin AG, Azlan W

Singapore Med J, 1994 Oct;35(5):529-31.

PMID: 7701380

A 3-day-old child presented with a gross swelling on the right side of the neck extending beyond the midline and inability to swallow. It was diagnosed to be cystic hygroma and decision was made to excise the swelling as an emergency operation to enable the child to swallow and thrive better. During the gaseous induction, difficulty was encountered in maintaining the airway and subsequently to intubate the patient. Intraoperatively the surgeon was not able to excise the tumour completely. Postoperatively it was decided to ventilate the child electively because of the intubation difficulties encountered and not so firm floor of the mouth because of surgical excision. The stay in the neonatal ICU was marked with infection and facial nerve palsy.

Matched MeSH terms: Tongue Neoplasms/surgery*

Glycogen-rich clear cell carcinoma in the tongue

Rajab E, Akmal SN, Nasir AM

J Laryngol Otol, 1994 Aug;108(8):716-8.

PMID: 7930932

The case of a minor salivary gland tumour, arising from the tongue, with nodal metastasis is presented. Biopsy of the tumour and fine-needle aspiration cytology of the neck swelling showed the presence of a clear cell carcinoma with evidence of nodal metastases. A commando operation was performed and the defect was reconstructed using a local tongue flap. The literature review indicated that the neoplasm was rare and its site of occurrence rather unusual.

Matched MeSH terms: Tongue Neoplasms/metabolism*; Tongue Neoplasms/pathology

Carcinoma of the tongue in Malaysians

Ramanathan K, Ganesan TJ, Raghavan KV

Mod Med Asia, 1978 Jul;14(7):56-8.

PMID: 683170

Matched MeSH terms: Tongue Neoplasms/etiology; Tongue Neoplasms/epidemiology*

Fulltext World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review

Pentenero M, Bowers LM, Jayasinghe R, Yap T, Cheong SC, Kerr AR, et al.

Oral Dis, 2019 Jun;25 Suppl 1(Suppl 1):88-101.

PMID: 31140697 DOI: 10.1111/odi.13076

BACKGROUND: Long non-coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis.

OBJECTIVES: To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lncRNAs in oral/tongue squamous cell carcinoma.

METHODS: PubMed, Scopus and Web of Science were used as search engines. Clinical, full-length, English language studies were included. PRISMA-ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lncRNAs with the presence of tumour and with clinicopathological features including survival.

RESULTS: Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lncRNAs.

CONCLUSIONS: Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.

Matched MeSH terms: Tongue Neoplasms/genetics*; Tongue Neoplasms/pathology

Cyclin D1 amplification in tongue and cheek squamous cell carcinoma

Mahdey HM, Ramanathan A, Ismail SM, Abraham MT, Jamaluddin M, Zain RB

Asian Pac J Cancer Prev, 2011;12(9):2199-204.

PMID: 22296356

INTRODUCTION: Several molecular markers have been studied for their usefulness as prognostic markers in oral squamous cell carcinoma (OSCC). One such molecular marker is cyclin D1 which is a proto-oncogene located on 11q13 in humans.

OBJECTIVE: To explore the feasibility of using cyclin D1 as a prognostic marker in tongue and cheek SCC by the fluorescent-in-situ hybridization (FISH) method.

METHODS: Fifty paraffin-embedded samples (25 each of cheek and tongue SCCs) were obtained from the archives of the Oral Pathology Diagnostic Laboratory. Sociodemographic data, histopathologic diagnoses, lymph node status and survival data were obtained from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS)coordinated by the Oral Cancer Research and Coordinating Centre (OCRCC), University of Malaya. The FISH technique was used to detect the amplification of cyclin D1 using the Vysis protocol. Statistical correlations of cyclin D1 with site and lymph node status were analyzed using the Fisher exact test. Kaplan-Meier and Log Rank (Mantel-Cox) test were used to analyze cyclin D1 amplification and median survival time.

RESULTS: Positive amplification of cyclin D1 was detected in 72% (36) of OSCCs. Detection of positive amplification for cyclin D1 was observed in 88% (22) and 56% (14) of the tongue and cheek tumors, respectively, where the difference was statistically significant (P=0.012). Lymph node metastasis of cheek SCCs showed a trend towards a significant association (P= 0.098) with cyclin D1 amplification whereas the lymph node metastasis of tongue SCC was clearly not significant (P=0.593).There was a statistically significant correlation between cyclin D1 positivity and survival rate (P=0.009) for overall SCC cases and (P<0.001) for cheek SCC cases.

CONCLUSION: The present study found that cyclin D1 amplification may differ in different subsites of OSCC (tongue vs cheek) and its positive amplification implies an overall poor survival in OSCCs, particularly those arising in cheeks.

Matched MeSH terms: Tongue Neoplasms/genetics*; Tongue Neoplasms/metabolism; Tongue Neoplasms/pathology

Fulltext Brachytherapy of tongue carcinoma in a patient with difficult airway: anesthetic considerations

Ghaffar ZA, Chong SE, Tan KL, Appalanaido GK, Musa MY, Hussin HB, et al.

J Contemp Brachytherapy, 2018 Dec;10(6):573-576.

PMID: 30662482 DOI: 10.5114/jcb.2018.79856

The practice of brachytherapy in unresectable tongue carcinoma is gaining popularity. However, this procedure poses specific anesthetic challenges, particularly challenges of airway sharing and a higher rate of difficult airway. We report a 74-year-old chronic smoker, chronic alcoholic with history of stroke, who had undergone brachytherapy for tongue carcinoma. Apart from a huge tongue tumor, he had an epiglottic mass but refused elective tracheostomy. This had led to a few critical states throughout the process of treatment, including a metabolic crisis due to thiamine deficiency and difficult airway crisis. To our best knowledge, there have been no reported case on a patient with vocal cord mass undergoing tongue brachytherapy. We hope sharing of this experience may aid the management of similar patients in future.

Matched MeSH terms: Tongue Neoplasms

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