MyMedR

Spontaneous pneumomediastinum is a rare condition in viral pneumonia. However, it can arise spontaneously in COVID-19 patients with no other risk factors. Here we present four cases of spontaneous pneumomediastinum in patients with COVID-19 pneumonia with no other precipitating factors.

Matched MeSH terms: Pneumonia, Viral*

Fulltext Ferritin level: A predictor of severity and mortality in hospitalized COVID-19 patients

Alroomi M, Rajan R, Omar AA, Alsaber A, Pan J, Fatemi M, et al.

Immun Inflamm Dis, 2021 Dec;9(4):1648-1655.

PMID: 34438471 DOI: 10.1002/iid3.517

INTRODUCTION: This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.

METHODS: Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000).

RESULTS: Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21-0.62; p pneumonia (OR = 8.48, 95% CI = 3.02-35.45; p 1000.

CONCLUSION: In this study, higher levels of serum ferritin were found to be an independent predictor of in-hоsрitаl mоrtаlity.

Matched MeSH terms: Pneumonia*

Fulltext Updates on Wuhan 2019 novel coronavirus epidemic

Kofi Ayittey F, Dzuvor C, Kormla Ayittey M, Bennita Chiwero N, Habib A

J Med Virol, 2020 Apr;92(4):403-407.

PMID: 32017153 DOI: 10.1002/jmv.25695

Matched MeSH terms: Pneumonia*; Pneumonia, Viral

Fulltext Letter to the Editor in response to "COVID-19: desperate times call for desperate measures"

Chase JG, Chiew YS, Lambermont B, Morimont P, Shaw GM, Desaive T

Crit Care, 2020 07 10;24(1):415.

PMID: 32650807 DOI: 10.1186/s13054-020-03152-6

Matched MeSH terms: Pneumonia, Viral*

Transient pneumonia

KADRI ZN

Med J Malaya, 1959 Jun;13:292-7.

PMID: 14408341

Matched MeSH terms: Pneumonia/radiography*

Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases

Mehta M, Paudel KR, Shukla SD, Allam VSRR, Kannaujiya VK, Panth N, et al.

J Control Release, 2021 09 10;337:629-644.

PMID: 34375688 DOI: 10.1016/j.jconrel.2021.08.010

Nuclear factor κB (NFκB) is a unique protein complex that plays a major role in lung inflammation and respiratory dysfunction. The NFκB signaling pathway, therefore becomes an avenue for the development of potential pharmacological interventions, especially in situations where chronic inflammation is often constitutively active and plays a key role in the pathogenesis and progression of the disease. NFκB decoy oligodeoxynucleotides (ODNs) are double-stranded and carry NFκB binding sequences. They prevent the formation of NFκB-mediated inflammatory cytokines and thus have been employed in the treatment of a variety of chronic inflammatory diseases. However, the systemic administration of naked decoy ODNs restricts their therapeutic effectiveness because of their poor pharmacokinetic profile, instability, degradation by cellular enzymes and their low cellular uptake. Both structural modification and nanotechnology have shown promising results in enhancing the pharmacokinetic profiles of potent therapeutic substances and have also shown great potential in the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease and cystic fibrosis. In this review, we examine the contribution of NFκB activation in respiratory diseases and recent advancements in the therapeutic use of decoy ODNs. In addition, we also highlight the limitations and challenges in use of decoy ODNs as therapeutic molecules, cellular uptake of decoy ODNs, and the current need for novel delivery systems to provide efficient delivery of decoy ODNs. Furthermore, this review provides a common platform for discussion on the existence of decoy ODNs, as well as outlining perspectives on the latest generation of delivery systems that encapsulate decoy ODNs and target NFκB in respiratory diseases.

Matched MeSH terms: Pneumonia*

Fulltext Detection rate of Pneumococcal Pneumonia using the Urine Antigen Kit BinaxNow Streptococcus Pneumoniae Test: a prospective cohort study in a Tertiary Hospital in Malaysia

Mohamed Faisal AH, Petrick P, Andrea YL Ban, Roslina AM

International Medical Journal Malaysia, 2017;16(1):29-36.

MyJurnal

Pneumococcal pneumonia is the commonest type of bacterial pneumonia worldwide. In Malaysia, the reported incidence of pneumococcal pneumonia is low. This may be due to poor sensitivity of conventional methods. The use of BinaxNOW, a urinary antigen test for Streptococcus pneumoniae can aid in the diagnosis of pneumococcal pneumonia.

Matched MeSH terms: Pneumonia, Pneumococcal; Pneumonia, Bacterial

ISOLATION AND CHARACTERIZATION OF BACTERIOPHAGE WITH LYTIC ACTIVITY AGAINST CARBAPENEM RESISTANCE STRAIN OF KLEBSIELLA PNEUMONIA

Baqer AA, Nor NSM, Alagely HS, Musa M, Adnan NA

Pol Merkur Lekarski, 2023;51(1):35-41.

PMID: 36960898 DOI: 10.36740/Merkur202301105

OBJECTIVE: Aim: Klebsiella pneumonia has emerged as an increasingly important cause of community-acquired nosocomial infections and many of these strains are highly virulent and exhibit a strong propensity to spread. Infections cause by K. pneumonia produces carbapen¬emase (KPC) enzyme and can be difficult to treat since only a few antibiotics are effective against them. Bacteriophage targeting this strain can be an alternative treatment. Characterisation of bacteriophage is utmost important in assisting the application of bacteriophage in phage therapy.

PATIENTS AND METHODS: Materials and methods: In the present study, the lytic bacteriophage, k3w7, isolated by the host Klebsiella pneumoniae kP2 was characterised using transmission electron microscope (TEM), plaque assay, and restriction digestive enzyme to investigate mor¬phology, host spectrum, bacteriophage life cycle and stability accordingly.

RESULTS: Results and conclusions: As shown by TEM, k3w7 was observed to have the characteristic of icosahedral heads 100 nm and contractile sheaths 120 nm suggesting it belongs to the family of myoviridae.The Investigation has done on the phage growth cycle showed a short latent period of 20 min and a burst size of approximately 220 plaque forming units per infected cell. Stability test showed the phage was stable over a wide range of pH and temperatures. According to restriction analysis, k3w7 had 50 -kb double-stranded DNA genome as well as the heterogeneous nature of genetic material. These findings suggest that K3W7 has a potential use in therapy against infections caused by K. pneumonia produces carbapenemase.

Matched MeSH terms: Klebsiella pneumoniae; Pneumonia*

Fulltext Association of frailty and mortality in patients with COVID-19: a meta-analysis

Kow CS, Hasan SS, Thiruchelvam K, Aldeyab M

Br J Anaesth, 2021 Mar;126(3):e108-e110.

PMID: 33358046 DOI: 10.1016/j.bja.2020.12.002

Matched MeSH terms: Pneumonia*

Fulltext The impact of COVID-19 and the restoration of tuberculosis services in the Western Pacific Region

Chiang CY, Islam T, Xu C, Chinnayah T, Garfin AMC, Rahevar K, et al.

Eur Respir J, 2020 Oct;56(4).

PMID: 32978310 DOI: 10.1183/13993003.03054-2020

While COVID-19 has imposed great challenges to national tuberculosis programmes, it has also created opportunities to develop innovative strategies to ensure continuity of TB services and ultimately to strengthen TB care, prevention and control https://bit.ly/3bHDQx0

Matched MeSH terms: Pneumonia, Viral*

Should All Children Admitted with Community Acquired Pneumonia have Blood Cultures Taken? Authors' Reply

Nathan AM, de Bruyne JA

Indian J Pediatr, 2015 Jul;82(7):660-1.

PMID: 25514886 DOI: 10.1007/s12098-014-1640-z

Matched MeSH terms: Pneumonia*; Pneumonia, Bacterial/drug therapy

Fulltext A case of pneumonia with complications

Wilson

Journal of the Straits Medical Association, 1894;5:107-14.

Matched MeSH terms: Pneumonia

A male with recurrent infections and mediastinal mass

Hamid FA, Hasbullah AHH, Ban AY

Breathe (Sheff), 2020 Dec;16(4):200065.

PMID: 33447285 DOI: 10.1183/20734735.0065-2020

Can you diagnose this patient with recurrent pneumonia and myasthenia gravis? https://bit.ly/2IBaxC1.

Matched MeSH terms: Pneumonia

Aureomycin treatment of bronchopneumonia

Loh SG

Med J Malaya, 1951;5.

A report is given of 60 cases of bronchopneumonia in infants treated with Aureomycin during a period of 4 months, Aureomycin was given orally in a mixture. Dosage depended on the severity of the infection, the age and weight of the patient. The results of this series are compared with a series of penicillin treated cases and showed a distinct improvement. The cure rate of Aureomycin treated cases is about 70%.

Matched MeSH terms: Pneumonia

Fulltext Marijuana "bong" pseudomonas lung infection: a detrimental recreational experience

Kumar AN, Soo CI, Ng BH, Hassan T, Ban AY, Manap RA

Respirol Case Rep, 2018 02;6(2):e00293.

PMID: 29321937 DOI: 10.1002/rcr2.293

The use of Cannabis sativa, also known as marijuana, is believed to have dated back to thousands of years B.C. More than 200 decades later, it remains a popular recreational psychoactive substance that can be smoked through a water pipe. We report a case of marijuana smoking via a "bong" device, which has resulted in severe Pseudomonas aeruginosa necrotizing pneumonia treated with conservative medical therapy. This case highlights the importance of recognizing that life-threatening pneumonia can potentially be linked to marijuana and "bong" usage. Complicated cases should be considered for early surgical intervention.

Matched MeSH terms: Pneumonia; Pneumonia, Necrotizing

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