Browse publications by year: 1991

  1. Elango S, Sivakumaran S
    J Laryngol Otol, 1991 Jul;105(7):582-3.
    PMID: 1875146
    Pseudomonas pseudomallei, a gram negative organism causing melioidosis, is found in tropical and subtropical regions. It may manifest as a pulmonary lesion, osteomyelitis, soft tissue abscesses, abscesses in various organs or in septicaemic form. Melioidosis of the parapharyngeal space has not been reported so far. A case of melioidosis of the parapharyngeal space which was successfully treated by drainage and prolonged antibiotic therapy is reported here. Melioidosis should be suspected in severe forms of deep neck space infection, especially if the patient comes from an endemic area.
    MeSH terms: Adult; Ceftazidime/therapeutic use; Combined Modality Therapy; Diabetes Mellitus, Type 1/complications*; Drainage; Humans; Male; Melioidosis/complications*; Melioidosis/therapy; Neck
  2. Razak IA, Latifah RJ, Nasruddin J, Esa R
    Clin Prev Dent, 1991 Jul-Aug;13(4):22-4.
    PMID: 1884572
    A questionnaire was mailed to 1217 dentists whose names appear in the Dentist Register of 1987 in order to assess their awareness and acceptance of hepatitis B vaccine and their pattern of glove usage. Almost all the respondents (99.6%) were aware of the availability of the hepatitis B vaccine yet only 44.8% have received the vaccine. This is in spite of the fact that the majority (61.2%) of the vaccine non-acceptors have no reservations concerning the vaccine. About 71% and 63% of the vaccine-acceptors and non-acceptors respectively believed that the risk of their contracting hepatitis B was high or very high. About 22% of the vaccine non-acceptors never used gloves when treating patients as compared to 9% among vaccine acceptors. Overall, about 78% of the respondents have experienced needleprick injuries in the 3 years preceding the survey.
    MeSH terms: Attitude of Health Personnel; Communicable Disease Control/methods; Dentists*; Gloves, Surgical/utilization; Hepatitis B/prevention & control*; Hepatitis B/transmission; Humans; Health Knowledge, Attitudes, Practice; Malaysia; Surveys and Questionnaires; Vaccination/utilization*; Viral Hepatitis Vaccines
  3. Lim TO
    Diabetes Res Clin Pract, 1991 Jul;12(3):201-7.
    PMID: 1889350 DOI: 10.1016/0168-8227(91)90078-R
    The prevalence, age at diagnosis, clinical characteristics and treatment of young diabetics, younger than 40 years were determined on the basis of a cross-sectional study of medical records of 2 health districts in Pahang, Malaysia. There were only 20 insulin-dependent diabetics (IDDM), prevalence 0.07 per 1000 inhabitants. There were 84 non-insulin-dependent diabetics (NIDDM), prevalence 0.3 per 1000 inhabitants. Three of the NIDDM patients could have malnutrition-related diabetes. Many NIDDM patients were asymptomatic which is an important reason why many of them remain undetected in the community. Seventy-four percent of the patients below the age of 30 years at diagnosis had NIDDM, 56% of the patients below the age of 20 years at diagnosis also had NIDDM and 54% of the NIDDM patients had a strong family history of diabetes. Many NIDDM patients were misdiagnosed as IDDM, especially if they were underweight, leading to considerable overuse of insulin. This study confirms that IDDM is rare in Malaysia, as in other Asian countries. Most young diabetics have NIDDM and have a strong family history. This pattern of diabetes in the young is unlike that seen in the West.
    MeSH terms: Adolescent; Adult; Age Factors; Child; Cross-Sectional Studies; Diabetes Mellitus, Type 1/diagnosis; Diabetes Mellitus, Type 1/epidemiology*; Diabetes Mellitus, Type 1/therapy; Diabetes Mellitus, Type 2/diagnosis; Diabetes Mellitus, Type 2/epidemiology*; Diabetes Mellitus, Type 2/therapy; Female; Humans; Malaysia/epidemiology; Male; Prevalence
  4. Chao TC, Maxwell SM, Wong SY
    J Pathol, 1991 Jul;164(3):225-33.
    PMID: 1890547
    An outbreak of food poisoning resulting in 13 deaths in children occurred in Malaysia during the Chinese Festival of the Nine-Emperor Gods in 1988. The offending food was a Chinese noodle called 'Loh See Fun' (LSF). The source was traced to a factory where a banned food preservative was added to make the LSF. The food poisoning was attributable to aflatoxins and boric acid. The clinical features included vomiting, pyrexia, diarrhoea, abdominal pain, anorexia, giddiness, seizures, and eventual coma. Initially, many presented with a Reye-like syndrome. Eleven post-mortem examinations were performed. The pathological findings included extensive coagulative necrosis of the liver with proliferative 'ductal/ductular metaplasia of the hepatocytes'. Giant cell formation, central vein sclerosis, bile stasis, and steatosis were also noted. There was presence of acute tubular necrosis, superficial upper gastrointestinal erosions, and ensuing encephalopathy. The eventual cause of death is acute hepatic and renal failure.
    MeSH terms: Aflatoxins/analysis; Aflatoxins/poisoning*; Boric Acids/poisoning*; Child; Child, Preschool; Diagnosis, Differential; Disease Outbreaks*; Female; Humans; Kidney/pathology; Liver/pathology; Malaysia; Male; Metaplasia/pathology; Middle Aged; Necrosis/pathology; Reye Syndrome/diagnosis; Mycotoxicosis/epidemiology; Mycotoxicosis/pathology*
  5. Siar CH, Ng KH, Jalil NA
    Oral Surg. Oral Med. Oral Pathol., 1991 Jul;72(1):82-5.
    PMID: 1891247
    Plexiform granular cell odontogenic tumor of the mandible has recently been described. The cardinal histopathologic feature, as its name suggests, is a monophasic plexiform pattern of granular cells; the principal tumor in the differential diagnosis is granular cell ameloblastoma. Unlike the two previously reported cases of plexiform granular cell odontogenic tumor, which occurred as solid tumors in elderly men, the lesion reported here is a unicystic variant occurring in a middle-aged woman.
    MeSH terms: Cell Nucleus/ultrastructure; Cytoplasm/ultrastructure; Diagnosis, Differential; Epithelium/pathology; Female; Humans; Mandibular Neoplasms/pathology*; Middle Aged; Odontogenic Tumors/pathology*
  6. Sim SM, Back DJ, Breckenridge AM
    Br J Clin Pharmacol, 1991 Jul;32(1):17-21.
    PMID: 1909542
    1. Zidovudine (3'-azido-3'-deoxythymidine; AZT) is the drug of proven efficacy available for the treatment of patients with AIDS or ARC. It is eliminated mainly by hepatic glucuronidation. Therefore, interference with this metabolic pathway may lead to enhancement of AZT effect or to increased toxicity of the drug. We have examined the effect of a number of drugs which themselves undergo glucuronidation on AZT conjugation by human liver microsomes in vitro. 2. AZT glucuronidation followed Michaelis-Menten kinetics. The apparent Km and Vmax values (mean +/- s.d., n = 5), were 2.60 +/- 0.52 mM and 68.0 +/- 23.4 nmol h-1 mg-1, respectively, as determined from Eadie-Hofstee plots. 3. Dideoxyinosine, sulphanilamide and paracetamol were essentially non-inhibitory at concentrations up to 10 mM (4 times the concentration of AZT in the incubation). The most marked inhibitory effects were seen with indomethacin, naproxen, chloramphenicol, probenecid and ethinyloestradiol, with enzyme activity decreased by 97.7, 94.9, 88.7, 83.4% and 79.0%, respectively, at a concentration of 10 mM. Other compounds producing some inhibition of AZT conjugation were oxazepam, salicylic acid and acetylsalicylic acid. 4. Further studies are necessary to characterise the inhibition observed but the method described enables a screen of potentially important drug interactions to be carried out.
    MeSH terms: Acetaminophen/pharmacology; Adolescent; Adult; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Male; Microsomes, Liver/drug effects*; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Middle Aged; Salicylates/pharmacology; Sulfanilamides/pharmacology; Glucuronosyltransferase/metabolism*; Zidovudine/analogs & derivatives; Zidovudine/metabolism*; Didanosine/pharmacology
  7. Jasni S, Zamri-Saad M, Mutalib AR, Sheikh-Omar AR
    Br. Vet. J., 1991 Jul-Aug;147(4):352-5.
    PMID: 1913132
    Twenty transport-stressed goats were divided into two groups. The first group was further stressed with steroid. Pasteurella haemolytica was found at various sites in the nasal cavity of goats in this group as early as 2 weeks post-transportation. The successful isolations continued consistently with more goats having pure growth of P. haemolytica at later stages. Mild catarrh rhinitis, loss of epithelial cilia and erosions were the main lesions observed in the nasal cavity. Goats in the second group that were not given steroid injections had inconsistent bacterial isolation and less severe pathological lesions.
    MeSH terms: Animals; Goats; Nasal Cavity/microbiology*; Pasteurellosis, Pneumonic/microbiology*; Transportation; Goat Diseases/microbiology*; Mannheimia haemolytica/isolation & purification*
  8. Elango S, Purohit GN, Hashim M, Hilmi R
    Int J Pediatr Otorhinolaryngol, 1991 Jul;22(1):75-80.
    PMID: 1917340
    In Malaysia 1,307 randomly selected primary school children were screened to find out the prevalence of hearing loss and middle ear disorders. Seventy-six students (5.81%) failed the screening audiometric test. There were 95 students (7.26%) with middle ear disorders. History of ear discharge was absent in 24 out of 57 cases with CSOM (42.11%) (P less than 0.001). Forty-three out of 95 children having middle ear disorders passed the screening audiometric test (P less than 0.01 Fisher exact test). Screening audiometric test fails to detect about 46% of cases with middle ear disorders. Screening audiometric test and otological examination if conducted by the school health medical officers regularly will be able to detect almost all the cases with hearing loss and middle ear disorders.
    MeSH terms: Audiometry; Child; Female; Hearing Disorders/diagnosis; Hearing Disorders/epidemiology*; Humans; Malaysia/epidemiology; Male; Otitis Media/epidemiology*; Prevalence
  9. Dorai CR, Kareem BA
    Injury, 1991 Jul;22(4):329-30.
    PMID: 1937735
    MeSH terms: Accidents, Traffic; Adult; Dislocations/etiology; Dislocations/surgery*; Humans; Male; Pubic Symphysis/injuries*; Rupture/surgery; Urethra/injuries
  10. Boon LC, Esa R
    ASDC J Dent Child, 1991 Jul-Aug;58(4):335-6.
    PMID: 1939798
    Cysts and tumors, including odontomas, can delay the eruption of teeth. In this case the delay was due to a denticle and a cyst.
    MeSH terms: Child; Dental Pulp Calcification/complications*; Dentigerous Cyst/complications*; Humans; Incisor; Maxilla; Tooth, Unerupted/etiology*
  11. Ngeow YF, Ramachandran S, Cheong YM
    Sex Transm Dis, 1991 7 1;18(3):192-4.
    PMID: 1948519
    Between January and August, 1989, 36 men and 28 women with uncomplicated lower genital tract infections by Neisseria gonorrhoeae were given single intramuscular injections of sulbactam (500 mg)/ampicillin (1000 mg) together with 1 g oral probenecid. Cure rates that were obtained were 100% for women, 97.2% for men, 100% for patients with penicillinase-producing Neisseria gonorrhoeae (PPNG), and 98.4% for patients with non-PPNG. No serious side effects were encountered, and patient acceptance of the drug was good. A high proportion of patients had concurrent chlamydial infection. Sulbactam/ampicillin was found to be effective against gonococcal urethritis and cervicitis by both PPNG and non-PPNG but have little effect on concomitant chlamydial infections, especially in women.
    MeSH terms: Adolescent; Adult; Ampicillin/administration & dosage; Ampicillin/pharmacology; Ampicillin/therapeutic use*; Female; Gonorrhea/drug therapy*; Humans; Injections, Intramuscular; Male; Middle Aged; Neisseria gonorrhoeae/drug effects; Sulbactam/administration & dosage; Sulbactam/pharmacology; Sulbactam/therapeutic use*
  12. Da Vanzo J, Starbird EH
    Stud Fam Plann, 1991 Jul-Aug;22(4):241-54.
    PMID: 1949106 DOI: 10.2307/1966480
    Recent research has shown that children born before and after short birth intervals run a considerably greater risk of dying in infancy or childhood than do others. This report investigates which women have short interbirth intervals, under what circumstances, and for what reasons. The analysis uses data from the Malaysian Family Life Survey to examine influences on the two main behaviors--breastfeeding and contraceptive use--that affect birth interval length, and assesses the the impact of these same variables on the probability of having a birth interval of less than 15 months. The analysis shows that many of the independent variables affect breastfeeding and contraceptive use in opposite directions, with no significant net effect on the likelihood of a short interval. For example, a woman's education is negatively related to the probability that she breastfeeds, positively related to the probability that she uses contraceptives, and has no significant effect on the likelihood that the interpregnancy interval is less than 15 months. Having a family planning clinic nearby is associated with less breastfeeding, offsetting whatever positive effects family planning clinics have on contraceptive use in terms of the percentage of birth intervals that are so short as to be detrimental to infant and child health. Hence, factors that increase contraceptive use do not necessarily reduce the incidence of short interbirth intervals, because they are also associated with reduced breastfeeding. We simulate the proportion of intervals that would be short for alternative combinations of breastfeeding and contraceptive use in the population and show that over the period covered by the data (1961-75), breastfeeding had a considerably greater effect on preventing short interbirth intervals than did contraceptive use.
    MeSH terms: Adult; Age Factors; Birth Intervals*; Breast Feeding*; Coitus; Contraception Behavior*; Educational Status; Family Planning Services; Female; Humans; Malaysia; Middle Aged; Parity; Sexual Behavior; Socioeconomic Factors
  13. Watson DA, Andrew JH, Banting S, Mackay JR, Stillwell RG, Merrett M
    Med J Aust, 1991 Jul 01;155(1):47-50.
    PMID: 2067439
    OBJECTIVE: To report a case of enteritis necroticans acquired in Australia, and to review the history, epidemiology, pathogenesis, clinical features, management and prevention of this disease.

    CLINICAL FEATURES: A 44-year-old diabetic and alcoholic restaurateur of Chinese-Malay origin, who had been living in Australia for over 20 years, was admitted to hospital with bloody diarrhoea which progressed to fulminant toxaemia and circulatory collapse, and ultimately required laparotomy. Typical pathological features and the isolation of Clostridium perfringens type C from faeces confirmed the diagnosis of enteritis necroticans.

    INTERVENTION AND OUTCOME: He was treated initially with ampicillin, gentamicin, metronidazole and chloramphenicol, and later with penicillin and metronidazole, and he required large volumes of intravenously administered fluid and blood for his toxaemic, hypotensive state. Laparotomy was performed as a life-saving procedure. Despite a lengthy convalescence, the patient recovered.

    CONCLUSIONS: Enteritis necroticans is a rare disease in developed countries, however it is likely to be underdiagnosed. Clinicians are encouraged to be on the alert for signs of severity that may indicate the need for laparotomy in a predisposed individual with features of this condition.

    MeSH terms: Adult; Anti-Bacterial Agents; Australia; China/ethnology; Clostridium perfringens*; Enteritis/diagnosis; Enteritis/microbiology*; Enteritis/pathology; Enteritis/therapy; Feces/microbiology; Humans; Intestinal Mucosa/pathology; Intestine, Small/pathology; Intestine, Small/surgery; Malaysia/ethnology; Male; Necrosis
  14. Petersen G
    Natl AIDS Bull, 1991 Jul;5(6):28-30.
    PMID: 12179697
    MeSH terms: Acquired Immunodeficiency Syndrome*; Asia; Asia, Southeastern; Developing Countries; Disease; Epidemiology*; Health; Pacific Islands; Public Health; Research; Research Design; Virus Diseases; HIV Infections*; Prevalence*
  15. Feeney G
    Asian Pac Popul Forum, 1991;5(2-3):51-5, 76-87.
    PMID: 12343438
    "The past 20 years have seen extensive elaboration, refinement, and application of the original Brass method for estimating infant and child mortality from child survivorship data. This experience has confirmed the overall usefulness of the methods beyond question, but it has also shown that...estimates must be analyzed in relation to other relevant information before useful conclusions about the level and trend of mortality can be drawn.... This article aims to illustrate the importance of data analysis through a series of examples, including data for the Eastern Malaysian state of Sarawak, Mexico, Thailand, and Indonesia. Specific maneuvers include plotting completed parity distributions and 'time-plotting' mean numbers of children ever born from successive censuses. A substantive conclusion of general interest is that data for older women are not so widely defective as generally supposed."
    MeSH terms: Americas; Asia; Asia, Southeastern; Birth Rate; Data Collection*; Demography*; Developing Countries; Fertility; Indonesia; Infant Mortality*; Latin America; Longevity; Malaysia; Methods*; Mexico; Models, Theoretical*; Mortality; North America; Parity*; Population; Population Characteristics; Population Dynamics; Research; Research Design*; Statistics as Topic*; Thailand; Time Factors*; Survival Rate; Censuses*
  16. Pit S, Jamal F, Cheah FK, Abbas MA
    Ann Saudi Med, 1991 Jul;11(4):424-8.
    PMID: 17590760
    Forty cases of cerebral abscesses were studied prospectively to establish the microbial agents implicated in these cases. Chronic otitis media (14 patients, 35%), congenital heart disease (five patients, 12.5%),a and meningitis (five patients, 12.5%) were among the important predisposing factors. Streptococcus (14 patients, 35%) was the most common causative pre-isolated, the predominant species being Streptococcus milleri (11 patients, 27.5%). Other organisms isolated included Proteus mirabilis in six patients (15%) and Staphylococcus aureus in five patients (12.5%). Anaerobes (12 patients, 30%), predominantly Bacteroides sp. (eight patients, 20%), played an important role in these cases, the majority of which were isolated in mixed cultures. Gas-liquid chromatographic analysis of pus detected the presence of anaerobes in another 11 cases of cerebral abscess, in which cultures of anaerobes were negative. Therefore, gas-liquid chromotography is useful as an adjunct to conventional bacteriological methods in providing a rapid and sensitive means of detecting anaerobes in pus obtained especially from patients who had received antibiotic therapy prior to hospitalization.
    MeSH terms: Anti-Bacterial Agents; Bacteroides; Brain Abscess; Heart Diseases; Hospitalization; Humans; Meningitis; Otitis Media; Proteus mirabilis; Staphylococcal Infections; Staphylococcus aureus; Streptococcus; Causality; Streptococcus milleri Group
  17. Gordon DM, Davis DR, Lee M, Lambros C, Harrison BA, Samuel R, et al.
    Am J Trop Med Hyg, 1991 Jul;45(1):49-56.
    PMID: 1867348
    Two hundred and seventy-five Orang Asli volunteers living in nine villages in the Pos Legap Valley of Perak State, peninsular Malaysia, participated in a prospective study designed to characterize the epidemiological, parasitological, and entomological characteristics of Plasmodium falciparum, P. vivax, and P. malariae malaria transmission. Prevalence rates for the three plasmodial species at initiation of the study ranged from 56% in the 0-4-year-old age group to 0% in individuals over the age of 40. Entomological surveys were conducted, enabling us to determine mosquito salivary gland-positive rates and entomological inoculation rates of 1.2 infectious mosquito bites per person per month for P. falciparum, 2.4 for P. vivax, and 0.3 for P. malariae. Cumulative incidence rates over the 16 weeks of the study, following radical cure of all volunteers, were 22.5% for P. falciparum, 12.7% for P. vivax, and 1.5% for P. malariae. The median baseline antibody titer against the immunodominant repetitive B cell epitope of P. falciparum or P. vivax circumsporozoite protein was significantly higher for volunteers who did not become parasitemic. Volunteers were selected for further study if they had evidence of being challenged with P. falciparum sporozoites during the study, based on a two-fold or greater increase in antibody titer against the immunodominant repetitive B cell epitope of the circumsporozoite protein. Resistance to infection was seen in six of 10 individuals who had high (greater than 25 OD units) baseline ELISA titers, compared with only three of 24 individuals who had low baseline ELISA titers (chi 2 P less than 0.02). A similar analysis for P. vivax did not show a significant correlation.
    MeSH terms: Adolescent; Adult; Animals; Antigens, Protozoan/immunology*; Child; Child, Preschool; Female; Humans; Infant; Malaria/immunology; Malaria/transmission*; Malaysia; Male; Plasmodium falciparum/immunology*; Plasmodium malariae/immunology*; Plasmodium vivax/immunology*; Protozoan Proteins*; Oceanic Ancestry Group*; Continental Population Groups
  18. Chan KL, Yushayati Y, Guganeswaran P
    Biochem Genet, 1991 Aug;29(7-8):337-44.
    PMID: 1747096
    A biochemical genetic study of the enzyme malate dehydrogenase (MDH) was conducted in the grasshopper Oxya j. japonica. Analysis of MDH electrophoretic variation in this species of grasshopper shows that one of the two autosomal loci for MDH in grasshoppers, the Mdh-2 locus, controlling the anodal set of MDH isozymes, is duplicated. Results of breeding studies confirm this and the observed polymorphism at the Mdh-2 locus in the two populations of Oxya j. japonica studied can be attributed to three forms of linked alleles at the duplicated locus in equilibrium in both populations. In this respect, all individuals of this species possess heterozygous allelic combinations at the duplicated Mdh-2 locus, which may account for the spread of the duplicated locus in the populations of this species of grasshopper.
    MeSH terms: Alleles; Animals; Female; Multigene Family*; Grasshoppers/genetics*; Isoenzymes/genetics; Malate Dehydrogenase/genetics*; Male; Phenotype; Polymorphism, Genetic*; Genetic Variation
  19. Looi LM
    Histopathology, 1991 Aug;19(2):169-72.
    PMID: 1757071
    Seventeen consecutive patients with dystrophic amyloidosis are reported here (eight Chinese, three Indian, three Iban, two Malay and one Caucasian). Ten were females and seven males, with ages ranging from 12 to 80 years (mean of 48 years). Five instances of dystrophic amyloidosis occurred in areas of tissue damage in the cardiovascular system, including fibrotic cardiac valves and an atheromatous plaque. Three occurred in osteoarthritic joint tissue. Of note were three occurrences in endometriotic cyst walls, four in the fibrotic walls of epidermal cysts, one in a hernial sac and one at the edge of a skin ulcer. All deposits were congophilic and exhibited green-birefringence and permanganate-resistance. Immunohistochemistry did not reveal reactivity for AA protein or immunoglobulin lambda or kappa light-chains. AP protein was detected in 35% of cases. Our results show that, besides the usual sites of osteoarthritic joints and damaged heart valves, dystrophic amyloidosis can complicate other areas of chronic tissue damage and fibrosis such as walls of cysts and ulcers. While the pathogenesis and biochemical nature remain unresolved, immunohistochemistry indicates that neither AA nor AL proteins are present in the deposits, and suggests that a different amyloid protein is involved.
    MeSH terms: Adolescent; Adult; Aged; Amyloidosis/pathology*; Child; Female; Heart Valves/pathology; Humans; Joints/pathology; Male; Middle Aged; Cardiomyopathies/pathology; Osteoarthritis/pathology
  20. Koh MT, Lim CT
    Singapore Med J, 1991 Aug;32(4):230-2.
    PMID: 1775999
    While it is not difficult to recognise the classical clinical features of congenital syphilis in most cases, some of them may present with unusual manifestations which can defy early diagnosis. We report our experience with 13 cases of early congenital syphilis over a period of 10 years from 1980 to 1989. Twelve of the thirteen patients were less than 3 months at presentation. There were two infants born prematurely and six of the babies were born with a low birthweight (less than 2.5 kg). All but four patients survived following treatment. Skin lesions either in the form of typical vesiculobullous eruption over the palms and soles or a maculopapular skin rash over the body were the most common presentation and was seen in 10 patients. Splenomegaly with or without hepatomegaly was the most consistent physical sign. Radiological changes in the form of periostitis and/or metaphysitis were seen in all cases where an X-ray of the long bones was performed. An elevated serum immunoglobulin M, though non-specific for the disease, was found to be a useful screening test for recent infection.
    MeSH terms: Female; Humans; Infant; Infant, Newborn; Male; Retrospective Studies
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