Browse publications by year: 2006

  1. Ngeow WC, Shim CK, Chai WL
    J Can Dent Assoc, 2006 Dec;72(10):927-31.
    PMID: 17187708
    Unintended intravascular injection from inferior alveolar nerve blocks can result in frustrating distant complications affecting such structures as the middle ear and eyes. Possible complications affecting the eyes include blurring of vision, diplopia, mydriasis, palpebral ptosis and amaurosis (temporary or permanent). In this article, we present a complication that has been reported only rarely. Two patients developed transient loss of power of accommodation of the eye resulting in blurred vision after routine inferior alveolar nerve blocks on the ipsilateral side. Clear vision returned within 10-15 minutes after completion of the blocks. The possible explanation for this phenomenon is accidental injection into the neurovascular bundle of local anesthetic agents, which were carried via the blood to the orbital region. This resulted in paralysis of a branch of cranial nerve III, the short ciliary nerves that innervate the ciliary muscle, which controls accommodation.
    MeSH terms: Accommodation, Ocular/drug effects*; Adult; Anesthesia, Dental/adverse effects*; Anesthesia, Dental/methods; Anesthetics, Local/administration & dosage; Anesthetics, Local/adverse effects*; Female; Humans; Injections, Intravenous/adverse effects; Lidocaine/administration & dosage; Lidocaine/adverse effects; Mandibular Nerve; Nerve Block/adverse effects*; Oculomotor Nerve/drug effects*; Vision Disorders/chemically induced
  2. Kumar V, Jumali IB
    Med Sci Law, 2006 Oct;46(4):301-9.
    PMID: 17191633
    The main aim of this study was to determine the causes and epidemiological aspects of paediatric death. Data was collected on 143 cases of paediatric death from a total of 2,895 autopsies performed in University Malaya Medical Centre (UMMC), Kuala Lumpur, over a five-year period from 2000 to 2004. There were 78 males and 65 females. The largest number of cases (32.9%) were stillborn. The highest proportion of cases (30.1%) were Chinese. The majority of cases of paediatric death were non-traumatic (74.8%) of which intrauterine death (IUD) was the most common (32.9%). Amongst the traumatic deaths (25.2%), accidental injury (23.8%) was observed in the majority of cases.
    MeSH terms: Accidents/mortality; Autopsy/statistics & numerical data; Cause of Death*; Child; Child, Preschool; Cross-Sectional Studies; Female; Homicide; Humans; Infant; Infant Mortality; Infant, Newborn; Malaysia/epidemiology; Male; Suicide/statistics & numerical data; Urban Population/statistics & numerical data*; Wounds and Injuries/mortality; Child Mortality; Stillbirth/epidemiology
  3. Kambara H, Yamada T, Tsujioka M, Matsunaga S, Tanaka R, Ali HI, et al.
    Chem Biodivers, 2006 Dec;3(12):1301-6.
    PMID: 17193244
    As a part of our chemical studies on Malaysian medicinal plants, five Malaysian plant species were evaluated by cytotoxicity assays using P388 murine leukemia cells. Since Acalypha siamensis exhibited the strongest growth inhibition, its constituents were studied as the object of search for bioactive materials. A novel tetraterpene, acalyphaser A (1), was isolated in the course of the purification. Its structure was elucidated on the basis of 1D- and 2D-NMR techniques, and mass spectrometry.
    MeSH terms: Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Antineoplastic Agents/chemistry; Cell Survival; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Indicators and Reagents/pharmacology; Models, Chemical; Magnetic Resonance Spectroscopy; Plant Extracts/chemical synthesis; Plant Extracts/pharmacology*; Plant Extracts/chemistry*; Mass Spectrometry/methods*; Terpenes/chemistry*; Tetrazolium Salts/pharmacology; Thiazoles/pharmacology; Euphorbiaceae; Cell Line, Tumor; Mice
  4. Maneesh M, Dutta S, Chakrabarti A, Vasudevan DM
    Indian J. Physiol. Pharmacol., 2006 Jul-Sep;50(3):291-6.
    PMID: 17193902
    Ethanol is a testicular toxin and it causes fertility abnormalities with low sperm count and impaired sperm motility in men. The present study was designed to investigate plasma testosterone level and hypothalamic pituitary gonadal (HPG) axis function in alcoholic men and also effect of ethanol on systemic oxidative stress. Forty six male alcohol abusers in the age group 20-40 years were selected. Fifty five, males in the same age group served as control. Alcohol abusers had significantly low plasma testosterone with low luteinizing hormone and follicle stimulating hormone. In addition they had significantly high thiobarbituric acid reactive substances (TBARS), superoxide dismutase and glutathione S-transferase, and low glutathione, ascorbic acid, catalase, glutathione reductase and glutathione peroxidase. Moreover, serum testosterone level in alcoholics negatively correlated with duration of alcohol abuse, and TBARS. Duration dependent decreased serum testosterone level in alcohol abusers might be due to 1) increased oxidative stress which can damage Leydig and supporting Sertoli cells and 2) impaired HPG axis.
    MeSH terms: Adult; Ethanol/toxicity; Alcoholism/blood*; Alcoholism/pathology; Antioxidants/analysis*; Central Nervous System Depressants/toxicity; Follicle Stimulating Hormone/blood; Humans; Leydig Cells/metabolism; Leydig Cells/pathology; Luteinizing Hormone/blood; Male; Pituitary Gland/metabolism; Sertoli Cells/metabolism; Sertoli Cells/pathology; Sperm Count; Sperm Motility/drug effects; Testosterone/blood*; Time Factors; Oxidative Stress/drug effects
  5. Anyamba A, Chretien JP, Small J, Tucker CJ, Linthicum KJ
    Int J Health Geogr, 2006 Dec 28;5:60.
    PMID: 17194307
    BACKGROUND: El Niño/Southern Oscillation (ENSO) related climate anomalies have been shown to have an impact on infectious disease outbreaks. The Climate Prediction Center of the National Oceanic and Atmospheric Administration (NOAA/CPC) has recently issued an unscheduled El Niño advisory, indicating that warmer than normal sea surface temperatures across the equatorial eastern Pacific may have pronounced impacts on global tropical precipitation patterns extending into the northern hemisphere particularly over North America. Building evidence of the links between ENSO driven climate anomalies and infectious diseases, particularly those transmitted by insects, can allow us to provide improved long range forecasts of an epidemic or epizootic. We describe developing climate anomalies that suggest potential disease risks using satellite generated data.

    RESULTS: Sea surface temperatures (SSTs) in the equatorial east Pacific ocean have anomalously increased significantly during July - October 2006 indicating the typical development of El Niño conditions. The persistence of these conditions will lead to extremes in global-scale climate anomalies as has been observed during similar conditions in the past. Positive Outgoing Longwave Radiation (OLR) anomalies, indicative of severe drought conditions, have been observed across all of Indonesia, Malaysia and most of the Philippines, which are usually the first areas to experience ENSO-related impacts. This dryness can be expected to continue, on average, for the remainder of 2006 continuing into the early part of 2007. During the period November 2006 - January 2007 climate forecasts indicate that there is a high probability for above normal rainfall in the central and eastern equatorial Pacific Islands, the Korean Peninsula, the U.S. Gulf Coast and Florida, northern South America and equatorial east Africa. Taking into consideration current observations and climate forecast information, indications are that the following regions are at increased risk for disease outbreaks: Indonesia, Malaysia, Thailand and most of the southeast Asia Islands for increased dengue fever transmission and increased respiratory illness; Coastal Peru, Ecuador, Venezuela, and Colombia for increased risk of malaria; Bangladesh and coastal India for elevated risk of cholera; East Africa for increased risk of a Rift Valley fever outbreak and elevated malaria; southwest USA for increased risk for hantavirus pulmonary syndrome and plague; southern California for increased West Nile virus transmission; and northeast Brazil for increased dengue fever and respiratory illness.

    CONCLUSION: The current development of El Niño conditions has significant implications for global public health. Extremes in climate events with above normal rainfall and flooding in some regions and extended drought periods in other regions will occur. Forecasting disease is critical for timely and efficient planning of operational control programs. In this paper we describe developing global climate anomalies that suggest potential disease risks that will give decision makers additional tools to make rational judgments concerning implementation of disease prevention and mitigation strategies.

    MeSH terms: Africa; Asia; Australia; Climate*; Disease Outbreaks; Humans; Infection/etiology*; Infection/epidemiology; Risk Factors; South America; United States; Weather
  6. Cheah YH, Azimahtol HL, Abdullah NR
    Anticancer Res, 2006 Nov-Dec;26(6B):4527-34.
    PMID: 17201174
    Xanthorrhizol is a natural sesquiterpenoid compound isolated from the rhizome of Curcuma xanthorrhiza Roxb (Zingiberaceae). Xanthorrhizol was tested for a variety of important pharmacological activities including antioxidant and anti-inflammatory activities. An antiproliferation assay using the MTT method indicated that xanthorrhizol inhibited the proliferation of the human breast cancer cell line, MCF-7, with an EC50 value of 1.71 microg/ml. Three parameters including annexin-V binding assay, Hoechst 33258 staining and accumulation of sub-G1 population in DNA histogram confirmed the apoptosis induction in response to xanthorrhizol treatment. Western-blotting revealed down-regulation of the anti-apoptotic bcl-2 protein expression. However, xanthorrhizol did not affect the expression of the pro-apoptotic protein, bax, at a concentration of 1 microg/ml, 2.5 microg/ml and 5 microg/ml. The level of p53 was greatly increased, whilst PARP-1 was cleaved to 85 kDa subunits, following the treatment with xanthorrhizol at a dose-dependent manner. These results, thereby, suggest that xanthorrhizol has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of bcl-2, p53 and PARP-1 protein levels.
    MeSH terms: Breast Neoplasms/genetics; Breast Neoplasms/pathology*; Humans; Phenols/pharmacology*; Gene Expression Regulation, Neoplastic/drug effects; Fluorescein-5-isothiocyanate/metabolism; Apoptosis/drug effects*; Annexin A5/metabolism; Cell Line, Tumor
  7. Onuma M, Suzuki M, Ohtaishi N
    Jpn. J. Vet. Res., 2006 Nov;54(2-3):135-9.
    PMID: 17201199
    The mitochondrial DNA control region of the sun bear (Helarctos malayanus) was sequenced using 21 DNA samples collected from confiscated sun bears to identify conservation units, such as evolutionarily significant units and management units, in Sarawak, Borneo Island. A total of 10 haplotypes were observed, indicating the presence of at least two lineages in the sun bear population in Sarawak. Presumably, these two lineages could represent evolutionarily significant units. However, the geographical distributions of the two lineages remained unknown due to the lack of information regarding the exact capture locations of the confiscated sun bears. It is essential to elucidate the geographical distributions of these lineages in order to create a proper conservation plan for the sun bears in Sarawak. Therefore, further studies examining the haplotype distributions using DNA samples from known localities are essential.
    MeSH terms: Animals; Ursidae/classification; Ursidae/genetics*; Conservation of Natural Resources*; DNA, Mitochondrial/genetics*; Female; Malaysia; Male; Phylogeny; Genetic Variation; Evolution, Molecular
  8. Gopinath VK, Musa M, Samsudin AR, Sosroseno W
    Br J Biomed Sci, 2006;63(4):176-8.
    PMID: 17201208
    MeSH terms: Animals; Cell Line; Latex; Macrophages/physiology*; Microspheres; Phagocytosis/immunology*; Tumor Necrosis Factor-alpha/immunology; Cytokines/physiology*; Durapatite; Autocrine Communication/physiology*; Mice; Interleukin-1beta/physiology
  9. Azidah AA, Sofian-Azirun M
    Bull. Entomol. Res., 2006 Dec;96(6):613-8.
    PMID: 17201979
    The incubation period of Spodoptera exigua (Hübner) was not influenced by the host plant, whereas larval development time and pupal period were affected. Larval development time was longest on shallot and lady's finger, followed by cabbage and long bean. Larvae did not develop beyond the first instar when fed on chilli. The pupal period was longer on lady's finger than on cabbage, shallot and long bean. Overall, adult longevity was not influenced by the host plant but there was a difference between female and male longevity among the host plants. Survival of S. exigua was affected by the host plant at the larval stage. The number of larval instars varied between 5 and 8 within and between the studied host plants. Long bean was found to be the most suitable host plant and provide the best food quality for S. exigua compared to the other host plants, as it allowed faster development, fewer larval instars and a higher survival rate.
    MeSH terms: Animals; Brassica/parasitology; Capsicum/parasitology; Female; Host-Parasite Interactions/physiology; Fabaceae/parasitology; Life Cycle Stages/physiology*; Longevity/physiology*; Male; Spodoptera/growth & development*; Crops, Agricultural/parasitology*; Shallots/parasitology; Abelmoschus/parasitology
  10. Banabilh SM, Rajion ZA, Samsudin R, Singh GD
    Aust Orthod J, 2006 Nov;22(2):99-103.
    PMID: 17203572
    To quantify and localise differences in Class I and Class II dental arches in Malay schoolchildren.
    MeSH terms: Adolescent; Cephalometry; Dental Arch/pathology*; Dental Models; Humans; Image Processing, Computer-Assisted; Malaysia; Malocclusion, Angle Class I/pathology; Malocclusion, Angle Class II/pathology*; Mandible/pathology; Maxilla/pathology; Finite Element Analysis
  11. Rahman RN, Baharum SN, Salleh AB, Basri M
    J Microbiol, 2006 Dec;44(6):583-90.
    PMID: 17205035
    In this study, an organic solvent tolerant bacterial strain was isolated. This strain was identified as Pseudomonas sp. strain S5, and was shown to degrade BTEX (Benzene, Toluene, Ethyl-Benzene, and Xylene). Strain S5 generates an organic solvent-tolerant lipase in the late logarithmic phase of growth. Maximum lipase production was exhibited when peptone was utilized as the sole nitrogen source. Addition of any of the selected carbon sources to the medium resulted in a significant reduction of enzyme production. Lower lipase generation was noted when an inorganic nitrogen source was used as the sole nitrogen source. This bacterium hydrolyzed all tested triglycerides and the highest levels of production were observed when olive oil was used as a natural triglyceride. Basal medium containing Tween 60 enhanced lipase production to the most significant degree. The absence of magnesium ions (Mg2+) in the basal medium was also shown to stimulate lipase production. Meanwhile, an alkaline earth metal ion, Na+, was found to stimulate the production of S5 lipase.
    MeSH terms: Olive Oil; Benzene/metabolism; Benzene/pharmacology; Benzene Derivatives/metabolism; Benzene Derivatives/pharmacology; Culture Media/chemistry; DNA, Bacterial/analysis; Lipase/metabolism*; Molecular Sequence Data; Peptones/metabolism; Plant Oils/metabolism; Polysorbates/metabolism; Pseudomonas/classification; Pseudomonas/enzymology*; Pseudomonas/genetics; Pseudomonas/growth & development; RNA, Ribosomal, 16S/genetics; Soil Microbiology*; Solvents/metabolism*; Solvents/pharmacology*; Toluene/metabolism; Toluene/pharmacology; Xylenes/metabolism; Xylenes/pharmacology; Gene Expression Regulation, Enzymologic
  12. Kamath S, Rao SG, Murthy KD, Bairy KL, Bhat S
    Indian J Exp Biol, 2006 Nov;44(11):902-4.
    PMID: 17205711
    Contribution and role of a pyramid/square box on the wound healing suppressant effect of dexamethasone was studied in rats of either sex using excision wound model to record the wound contraction rate and epithelization period. The results showed enhanced wound contraction rate and decreased epithelization period in the pyramid-exposed rats as compared to controls. Thus, it appears that pyramid environment facilitates the process of wound healing. Also, the wound healing suppressant effects of dexamethasone were significantly reduced.
    MeSH terms: Animals; Dexamethasone/adverse effects; Environment; Female; Male; Models, Biological; Steroids/adverse effects*; Wound Healing/drug effects*; Rats, Wistar; Rats
  13. Haque A
    J Appl Anim Welf Sci, 2006;9(4):333-5.
    PMID: 17209757
    The artificial living conditions of captive animals present numerous challenges for animal caretakers. In this study I explored abnormal behaviors in certain caged animals at the Kuala Lumpur Zoo. Findings obtained from observations of animals and interviews of the zoo staff are followed by recommendations: including the development of standards and manuals, licensing of zoos and animals, and increased budgets from governments or alternative sources. Such interventions should bring considerable improvements in animal welfare at the zoos in the region.
    MeSH terms: Animals; Animal Husbandry/methods; Animal Husbandry/standards*; Animal Welfare; Animals, Zoo/physiology*; Animals, Zoo/psychology*; Behavior, Animal/physiology*; Housing, Animal/standards; Humans; Malaysia; Caregivers/education*; Caregivers/psychology*
  14. Quoilin S, Lambion N, Mak R, Denis O, Lammens C, Struelens M, et al.
    Euro Surveill, 2006 Dec 21;11(12):E061221.2.
    PMID: 17213570
    MeSH terms: Adolescent; Adult; Belgium/epidemiology; Female; Football/injuries*; Humans; Hygiene; Malaysia; Male; Middle Aged; Surveys and Questionnaires; Streptococcal Infections/etiology; Streptococcal Infections/microbiology; Streptococcal Infections/epidemiology*; Streptococcal Infections/prevention & control; Streptococcus pyogenes/classification; Streptococcus pyogenes/isolation & purification*; Travel; Wound Infection/etiology; Wound Infection/microbiology; Wound Infection/epidemiology*; Wound Infection/prevention & control; Contact Tracing; Soft Tissue Injuries/complications*; Soft Tissue Injuries/microbiology; Soft Tissue Infections/etiology; Soft Tissue Infections/microbiology; Soft Tissue Infections/epidemiology*; Soft Tissue Infections/prevention & control
  15. Arshad AR
    Ann Acad Med Singap, 2006 Dec;35(12):889-91.
    PMID: 17219001
    INTRODUCTION: Benign tumours of the parotid gland constitute about 80% of parotid tumours. The most common benign tumour of the parotid gland is pleomorphic adenoma. Other conditions, like Kimura's disease, may mimic a tumour when they present as a parotid mass. Various modes of treatment have been advocated for the treatment of benign parotid lesions, ranging from enucleation to near-total parotidectomy.

    MATERIAL AND METHODS: This is an audit of an 18-year period where 173 lesions of the parotid gland (34 malignant and 139 benign lesions) were treated by the author.

    RESULTS: There were 139 benign lesions, of which 123 were benign tumours and 16 non-tumour conditions. Fourteen cases of recurrent pleomorphic adenoma of parotid that had been treated elsewhere were also operated on. Near-total parotidectomy was performed on all these cases with benign lesions.

    CONCLUSIONS: There has been no recurrence in all the patients who was treated this way. Near-total parotidectomy should be considered when there is a need to treat benign parotid swellings.

    MeSH terms: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Humans; Lymphoma/surgery; Male; Middle Aged; Adenoma, Pleomorphic/surgery; Parotid Gland/surgery*; Parotid Neoplasms/surgery*; Retrospective Studies
  16. Sriraam N, Eswaran C
    J Med Syst, 2006 Dec;30(6):439-48.
    PMID: 17233156
    Two-stage lossless data compression methods involving predictors and encoders are well known. This paper discusses the application of context based error modeling techniques for neural network predictors used for the compression of EEG signals. Error modeling improves the performance of a compression algorithm by removing the statistical redundancy that exists among the error signals after the prediction stage. In this paper experiments are carried out by using human EEG signals recorded under various physiological conditions to evaluate the effect of context based error modeling in the EEG compression. It is found that the compression efficiency of the neural network based predictive techniques is significantly improved by using the error modeling schemes. It is shown that the bits per sample required for EEG compression with error modeling and entropy coding lie in the range of 2.92 to 6.62 which indicates a saving of 0.3 to 0.7 bits compared to the compression scheme without error modeling.
    MeSH terms: Diagnostic Errors/prevention & control*; Electroencephalography/methods*; Humans; Malaysia; Neural Networks (Computer)*; Data Compression/methods*
  17. Keays SL, Bullock-Saxton JE, Newcombe P, Bullock MI
    Physiother Res Int, 2006 Dec;11(4):204-18.
    PMID: 17236528
    BACKGROUND AND PURPOSE: Little evidence supports the prescription of pre-operative rehabilitation in the treatment of chronic anterior cruciate ligament-deficient (ACLD) subjects. The aim of the present study was to assess the effectiveness of a specific six-week pre-operative exercise programme on ACLD knees.

    METHOD: A single, masked, controlled study was designed. This comprised two matched groups of 12 chronically ACLD patients awaiting reconstruction and a group of 12 matched uninjured control subjects. Only one ACLD group received a home-based exercise and educational programme. Assessment before and after the exercise intervention included: knee joint stability (clinical and KT1000 evaluation); muscle strength (Cybex II); standing balance and functional performance (agility, [corrected] and subjective tests).

    RESULTS: At the time of initial assessment there were no statistically significant differences in any measures for the two ACLD groups but both ACLD groups were significantly different from the uninjured control group as regards quadriceps strength and function. Measures taken after six weeks showed no significant improvement in the untreated ACLD group or in the uninjured control group. The treated ACLD group showed significant improvement in the following measures: quadriceps strength measured at 60 degrees and 120 degrees per second (p < 0.001); single leg standing balance with eyes closed (p < 0.001); instrumented passive stability at 20 lb (89 N) force (p = 0.003); agility and subjective performance (p < 0.001). The incidence of unstable episodes had decreased in the treated ACLD group, reducing further damage to the joint.

    CONCLUSION: This study leaves little doubt that pre-operative physiotherapy had a positive effect on motor function in ACLD subjects and should be prescribed routinely to maximize muscle stabilizing potential prior to reconstruction. Patients report improved stability and, in certain cases, may avoid surgery. The finding that exercise increased the passive stability of the joint was unexpected and requires further investigation.

    MeSH terms: Adult; Chronic Disease; Combined Modality Therapy; Postural Balance; Exercise Therapy*; Female; Home Care Services*; Humans; Joint Instability/physiopathology; Joint Instability/rehabilitation*; Joint Instability/surgery; Knee Injuries/physiopathology; Knee Injuries/rehabilitation*; Knee Injuries/surgery; Male; Preoperative Care; Rupture; Anterior Cruciate Ligament/surgery; Treatment Outcome; Muscle Strength; Anterior Cruciate Ligament Injuries*
  18. Aljunid SM
    Med J Malaysia, 2006 Aug;61(3):271-3.
    PMID: 17240573
    MeSH terms: Clinical Competence/standards; Cost-Benefit Analysis; Delivery of Health Care/economics*; Developing Countries; Medical Laboratory Science/economics; Medical Laboratory Science/trends
  19. Gendeh BS
    Med J Malaysia, 2006 Aug;61(3):274-7.
    PMID: 17240574
    MeSH terms: Cranial Fossa, Posterior; Humans; Pituitary Gland/surgery*; Sella Turcica; Sphenoid Sinus; Minimally Invasive Surgical Procedures/methods*
  20. Chin SP, Sapari S, How SH, Sim KH
    Med J Malaysia, 2006 Aug;61(3):278-83.
    PMID: 17240575 MyJurnal
    Evidence-based heart failure management now includes beta-blockers and spironolactone in addition to diuretics and angiotensin-converting enzyme inhibitors. We aim to determine if these recommendations had been applied in practice for acute and chronic stable heart failure, and what difficulties there might be. Data from 80 consecutive patients hospitalized for decompensated heart failure ('acute') between May and July 2003 were analyzed at admission, upon discharge and at 12 weeks follow-up; along with 74 cardiology clinic out-patients with stable congestive heart failure ('chronic'- no decompensation or admission in previous six months). Less than half of study patients with prior left ventricular dysfunction were on ACE-inhibitors (47%), diuretics (39%), ATII antagonists, spironolactone or digoxin (5% each). All 'acute' patients were commenced on diuretics and ACE-inhibitors in hospital. Six patients died or transferred to another center. Compliance with clinic appointment at 12 weeks was 85% despite telephone reminders. Drug prescription at 12 weeks was significantly lower for diuretics and ACE-inhibitors compared to prescription at discharge (all p < 0.05) but higher compared to patients with chronic HF. Diuretics and ACE inhibitors remain under-utilized for patients with recurrent heart failure. Use of spironolactone and beta-blocker is slow due to limited medical experience and funding. Clinic non-attendance is significant and due to patient factors.
    MeSH terms: Acute Disease; Adult; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Chronic Disease; Diuretics/therapeutic use; Female; Heart Failure/drug therapy*; Hospitals; Humans; Malaysia; Male; Middle Aged; Outpatient Clinics, Hospital; Patient Compliance; Cohort Studies; Evidence-Based Medicine; Angiotensin Receptor Antagonists*
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