A study on medicinal plants from Malaysia focused on Acalypha siamensis Oliv. ex Gage. isolation and structure of a new tetraterpene, acalyphaser A

Kambara H 1 , Yamada T , Tsujioka M , Matsunaga S , Tanaka R , Ali HI Show all authors , Wiart C , Yusof M , Hassan H , Hanifah A , Fauzi ZM , Mazlan NH , Jay M , Kunishima M , Akaho E

Affiliations 

  • 1 Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development, Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan
Chem Biodivers, 2006 Dec;3(12):1301-6.
PMID: 17193244

Abstract

As a part of our chemical studies on Malaysian medicinal plants, five Malaysian plant species were evaluated by cytotoxicity assays using P388 murine leukemia cells. Since Acalypha siamensis exhibited the strongest growth inhibition, its constituents were studied as the object of search for bioactive materials. A novel tetraterpene, acalyphaser A (1), was isolated in the course of the purification. Its structure was elucidated on the basis of 1D- and 2D-NMR techniques, and mass spectrometry.

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