Browse publications by year: 2018

  1. Safdar MH, Hasan H, Afzal S, Hussain Z
    Mini Rev Med Chem, 2018;18(12):1047-1063.
    PMID: 29173165 DOI: 10.2174/1389557517666171123212039
    The immune system is an intricate and coordinated nexus serving as a natural defense to preclude internal and external pathogenic insults. The deregulation in the natural balance of immunological functions as a consequence of either over expression or under expression of immune cells tends to cause disruption of homeostasis in the body and may lead to development of numerous immune system disorders. Chalcone moieties (1,3-diphenyl-2-propen-1-one) have been well-documented as ideal lead compounds or precursors to design a wide range of pharmacologically active agents to down-regulate various immune disorders. Owing to their unique structural and molecular framework, these α, β-unsaturated carbonyl-based moieties have also gained remarkable recognition due to their other multifarious pharmacological properties including antifungal, anti-inflammatory, anti-malarial, antibacterial, anti-tuberculosis, and anticancer potential. Though a great number of methodologies are currently being employed for their synthesis, this review mainly focuses on the natural and synthetic chalcone derivatives that are exclusively synthesized via Claisen-Schmidt condensation reaction and their immunomodulatory prospects. We have critically reviewed the literature and provided convincing evidence for the promising efficacy of chalcone derivatives to modulate functioning of various innate and adaptive immune players including granulocytes, mast cells, monocytes, macrophages, platelets, dendritic cells, natural killer cells, and T-lymphocytes.
    MeSH terms: Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Anti-Inflammatory Agents, Non-Steroidal/chemistry; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Anti-Bacterial Agents/chemistry; Antifungal Agents/chemical synthesis; Antifungal Agents/pharmacology; Antifungal Agents/chemistry; Antimalarials/chemical synthesis; Antimalarials/pharmacology; Antimalarials/chemistry; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Antineoplastic Agents/chemistry; Biological Products/chemical synthesis; Biological Products/pharmacology*; Biological Products/chemistry; Chalcone/chemical synthesis; Chalcone/pharmacology*; Chalcone/chemistry; Humans; Immunomodulation
  2. Ch'ng LS, Amzar H, Ghazali KC, Siam F
    Clin Radiol, 2018 03;73(3):321.e11-321.e16.
    PMID: 29174175 DOI: 10.1016/j.crad.2017.10.016
    AIM: To review computed tomography (CT), ultrasound (US), magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiogram (PTC) appearances and their diagnostic value in hepatic tuberculosis.

    MATERIALS AND METHODS: The imaging studies for 12 patients with biopsy-proven hepatic tuberculosis from January 2012 till March 2014 were reviewed retrospectively. These cases were confirmed via ultrasound-guided biopsy.

    RESULTS: The patients were aged 24-72 years. Four patients had parenchymal tuberculosis only and eight patients had mixed parenchymal and biliary duct involvement. The parenchymal tuberculosis patients showed poorly enhancing, hypodense nodules on CT with central calcification and adjacent dilated intrahepatic ducts. Most patients had multiple lesions except for two patients with a single lesion. The size of the lesions ranged from 0.5 to 6 cm. Seven patients with biliary duct involvement showed a hilar strictures involving the intrahepatic ducts and common bile duct. Nine of the patients showed hilar stricture with atrophy of the ipsilateral lobe of the liver and compensatory hypertrophy of the contralateral lobe. Hepatolithiasis was seen in five patients. Tuberculous lung involvement was seen in seven patients.

    CONCLUSION: The presence of calcified and hypodense nodules with biliary duct dilatation associated with lobar atrophy were the most consistent features of hepatic tuberculosis, especially in the presence of active lung disease.

    MeSH terms: Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Retrospective Studies; Image-Guided Biopsy
  3. Hematpoor A, Paydar M, Liew SY, Sivasothy Y, Mohebali N, Looi CY, et al.
    Chem Biol Interact, 2018 Jan 05;279:210-218.
    PMID: 29174417 DOI: 10.1016/j.cbi.2017.11.014
    The aim of the present study is to isolate bioactive compounds from the roots of Piper sarmentosum and examine the mechanism of action using human breast cancer cell line (MDA-MB-231). Bioassay guided-fractionation of methanolic extract led to the isolation of asaricin (1) and isoasarone (2). Asaricin (1) and isoasarone (2) had significant cytotoxicity towards MDA-MB-231. MCF-10A (human normal breast epithelial cells) cells are less sensitive than MDA-MB-231, but they respond to the treatment with the same unit of measurement. Both compounds increase reactive oxygen species (ROS), decrease mitochondrial membrane potential (MMP) and enhance cytochrome c release in treated MDA-MB-231 cells. Isoasarone (2) markedly elevated caspase -8 and -3/7 activities and caused a decline in nuclear NF-κB translocation, suggesting extrinsic, death receptor-linked apoptosis pathway. Quantitative PCR results of MDA-MB-231 treated with asaricin (1) and isoasarone (2) showed altered expression of Bcl-2: Bax level. The inhibitory potency of these isolates may support the therapeutic uses of these compounds in breast cancer.
    MeSH terms: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Survival/drug effects; Dose-Response Relationship, Drug; Female; Humans; Mitochondria/drug effects*; Mitochondria/metabolism; Phenylpropionates/pharmacology*; Phenylpropionates/chemistry; Molecular Structure; Apoptosis/drug effects*; Reactive Oxygen Species/metabolism*; Piper/chemistry*; Cell Line, Tumor
  4. Sankaran R, Show PL, Lee SY, Yap YJ, Ling TC
    Bioresour Technol, 2018 Feb;250:306-316.
    PMID: 29174909 DOI: 10.1016/j.biortech.2017.11.050
    Liquid Biphasic Flotation (LBF) is an advanced recovery method that has been effectively applied for biomolecules extraction. The objective of this investigation is to incorporate the fermentation and extraction process of lipase from Burkholderia cepacia using flotation system. Initial study was conducted to compare the performance of bacteria growth and lipase production using flotation and shaker system. From the results obtained, bacteria shows quicker growth and high lipase yield via flotation system. Integration process for lipase separation was investigated and the result showed high efficiency reaching 92.29% and yield of 95.73%. Upscaling of the flotation system exhibited consistent result with the lab-scale which are 89.53% efficiency and 93.82% yield. The combination of upstream and downstream processes in a single system enables the acceleration of product formation, improves the product yield and facilitates downstream processing. This integration system demonstrated its potential for biomolecules fermentation and separation that possibly open new opportunities for industrial production.
    MeSH terms: Fermentation*; Lipase*; Burkholderia cepacia*
  5. Lim KT, Amanah A, Chear NJ, Zahari Z, Zainuddin Z, Adenan MI
    Exp Parasitol, 2018 Jan;184:57-66.
    PMID: 29175017 DOI: 10.1016/j.exppara.2017.11.007
    In our ongoing work searching for new trypanocidal lead compounds from Malaysian plants, two known piperidine alkaloids (+)-spectaline (1) and iso-6-spectaline (2) were isolated from the leaves of Senna spectabilis (sin. Cassia spectabilis). Analysis of the 1H and 13C NMR spectra showed that 1 and 2 presented analytical and spectroscopic data in full agreement with those published in the literature. All compounds were screened in vitro against Trypanosoma brucei rhodesiense in comparison to the standard drug pentamidine. Compound 1 and 2 inhibited growth of T. b. rhodesiense with an IC50 value of 0.41 ± 0.01 μM and 0.71 ± 0.01 μM, without toxic effect on L6 cells with associated a selectivity index of 134.92 and 123.74, respectively. These data show that piperidine alkaloids constitute a class of natural products that feature a broad spectrum of biological activities, and are potential templates for the development of new trypanocidal drugs. To our knowledge, the compounds are being reported for the first time to have inhibitory effects on T. b. rhodesiense. The ultrastructural alterations in the trypanosome induced by 1 and 2, leading to programmed cell death were characterized using electron microscopy. These alterations include wrinkling of the trypanosome surface, formation of autophagic vacuoles, disorganization of kinetoplast, and swelling of the mitochondria. These findings evidence a possible autophagic cell death.
    MeSH terms: Animals; Biological Assay; Cell Line; Humans; Microscopy, Electron, Scanning; Piperidines/isolation & purification; Piperidines/pharmacology*; Piperidines/toxicity; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Plant Extracts/toxicity; Trypanocidal Agents/isolation & purification; Trypanocidal Agents/pharmacology*; Trypanocidal Agents/toxicity; Trypanosoma brucei rhodesiense/drug effects*; Trypanosoma brucei rhodesiense/growth & development; Trypanosoma brucei rhodesiense/ultrastructure; Plant Leaves/chemistry; Inhibitory Concentration 50; Senna Plant/classification; Senna Plant/chemistry*; Myoblasts, Skeletal/drug effects; Microscopy, Electron, Transmission; Rats; Carbon-13 Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy
  6. Ho TK, Satterthwaite JD, Silikas N
    Dent Mater, 2018 02;34(2):e15-e24.
    PMID: 29175160 DOI: 10.1016/j.dental.2017.11.014
    OBJECTIVE: To assess the change in surface roughness of nanohybrid resin composite (Tetric EvoCeram) after antagonist wear against monolithic zirconia and lithium disilicate ceramics through a simulated chewing test using a three-dimensional (3D) profilometer.

    METHODS: A total of 40 Tetric EvoCeram™ resin composite specimens against either a Lava™ Plus zirconia antagonist (n=20) or IPS e.max Press lithium disilicate antagonist (n=20) were prepared for the study. The surface roughness profiles of each resin composite before and after an in-vitro simulated chewing test were analysed using a 3D profilometer and Talymap software. After the simulated chewing, the surface profiles of representative Tetric EvoCeram specimens from each group were analysed using scanning electron microscopy. Independent t-test and paired t-test were used for statistical analysis.

    RESULTS: For both lithium disilicate and zirconia groups, all surface roughness parameters (Ra, Rt, Sa, Sq,) of Tetric EvoCeram were significantly higher post-chewing compared to pre-chewing (p<0.05); the post-chewing surface roughness parameters of Tetric EvoCeram for the lithium disilicate group were significantly higher (p<0.05) than in the zirconia group.

    SIGNIFICANCE: This chewing simulation test showed that Tetric EvoCeram composites exhibited a rougher surface when opposing lithium disilicate ceramic compared to opposing zirconia ceramic.

    MeSH terms: Composite Resins/chemistry*; Dental Materials/chemistry*; Dental Porcelain/chemistry*; Mastication*; Materials Testing; Software; Surface Properties; Zirconium/chemistry*
  7. Soon CY, Tee YB, Tan CH, Rosnita AT, Khalina A
    Int J Biol Macromol, 2018 Mar;108:135-142.
    PMID: 29175166 DOI: 10.1016/j.ijbiomac.2017.11.138
    Large amount of sodium hydroxide (NaOH) is consumed to remove the protein content in chitin biomass during deproteinization. However, excessive NaOH concentration used might lead to the reduction of cost effectiveness during chitin extraction. Hence, the present study aimed to extract and evaluate the physicochemical properties of chitin and chitosan isolated from superworm (Zophobas morio) larvae using 0.5M-2.0M of NaOH. The extracted chitin and chitosan were subjected to Fourier Transform Infrared Spectroscopy (FT-IR), elemental analysis, Scanning Electron Microscope (SEM), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD). The 0.5M NaOH treatment resulted in the highest yield of chitin (5.43%), but produced the lowest yield (65.84%) of chitosan. The extracted chitin samples had relatively high degree of acetylation (DA) (82.39%-101.39%). Both chitin and chitosan showed smooth surface with tiny pores. The extracted chitin samples were confirmed as α-chitin based on the FT-IR and TGA. The chitin samples were amorphous with low degree of crystallinity. From TGA, the Chitosan 3 extracted was partially deacetylated. Both DPPH radical scavenging and ferric-chelating assay showed positive correlation with DD of chitosan isolates. However, the chitosan isolates were not fully dissolved, resulting in lower radical scavenging and ferric-chelating ability compared to commercial chitosan.
    MeSH terms: Animals; Beetles/chemistry*; Chitin/isolation & purification*; Chitin/chemistry; Chemical Fractionation/methods*; Larva/chemistry*; Sodium Hydroxide/chemistry*; Spectroscopy, Fourier Transform Infrared; Chitosan/isolation & purification*; Chitosan/chemistry; Chemical Phenomena*
  8. Chong HY, Lim YH, Prawjaeng J, Tassaneeyakul W, Mohamed Z, Chaiyakunapruk N
    Pharmacogenet Genomics, 2018 02;28(2):56-67.
    PMID: 29176400 DOI: 10.1097/FPC.0000000000000319
    OBJECTIVE: Studies found a strong association between allopurinol-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and the HLA-B*58:01 allele. HLA-B*58:01 screening-guided therapy may mitigate the risk of allopurinol-induced SJS/TEN. This study aimed to evaluate the cost-effectiveness of HLA-B*58:01 screening before allopurinol therapy initiation compared with the current practice of no screening for Malaysian patients with chronic gout in whom a hypouricemic agent is indicated.

    METHODS: This cost-effectiveness analysis adopted a societal perspective with a lifetime horizon. A decision tree model coupled with Markov models were developed to estimate the costs and outcomes, represented by quality-adjusted life years (QALYs) gained, of three treatment strategies: (a) current practice (allopurinol initiation without HLA-B*58:01 screening); (b) HLA-B*58:01 screening before allopurinol initiation; and (c) alternative treatment (probenecid) without HLA-B*58:01 screening. The model was populated with data from literature review, meta-analysis, and published government documents. Cost values were adjusted for the year 2016, with costs and health outcomes discounted at 3% per annum. A series of sensitivity analysis including probabilistic sensitivity analysis were carried out to determine the robustness of the findings.

    RESULTS: Both HLA-B*58:01 screening and probenecid prescribing were dominated by current practice. Compared with current practice, HLA-B*58:01 screening resulted in 0.252 QALYs loss per patient at an additional cost of USD 322, whereas probenecid prescribing resulted in 1.928 QALYs loss per patient at an additional cost of USD 2203. One SJS/TEN case would be avoided for every 556 patients screened. At the cost-effectiveness threshold of USD 8695 per QALY, the probability of current practice being the best choice is 99.9%, in contrast with 0.1 and 0% in HLA-B*58:01 screening and probenecid prescribing, respectively. This is because of the low incidence of allopurinol-induced SJS/TEN in Malaysia and the lower efficacy of probenecid compared with allopurinol in gout control.

    CONCLUSION: This analysis showed that HLA-B*58:01 genetic testing before allopurinol initiation is unlikely to be a cost-effective intervention in Malaysia.
    MeSH terms: Alleles; Allopurinol/adverse effects; Cost-Benefit Analysis*; Female; Genetic Testing/economics*; Genotype; Gout; Heterozygote; Humans; Malaysia; Malaysia/epidemiology; Male; Middle Aged; Probenecid/administration & dosage; Risk Factors; Stevens-Johnson Syndrome/drug therapy; Stevens-Johnson Syndrome/economics*; Stevens-Johnson Syndrome/genetics; Stevens-Johnson Syndrome/epidemiology; HLA-B Antigens/genetics*; Quality-Adjusted Life Years
  9. Abolnik C, Mubamba C, Wandrag DBR, Horner R, Gummow B, Dautu G, et al.
    Transbound Emerg Dis, 2018 Apr;65(2):e393-e403.
    PMID: 29178267 DOI: 10.1111/tbed.12771
    It is widely accepted that Newcastle disease is endemic in most African countries, but little attention has been afforded to establishing the sources and frequency of the introductions of exotic strains. Newcastle disease outbreaks have a high cost in Africa, particularly on rural livelihoods. Genotype VIIh emerged in South-East Asia and has since caused serious outbreaks in poultry in Malaysia, Indonesia, southern China, Vietnam and Cambodia. Genotype VIIh reached the African continent in 2011, with the first outbreaks reported in Mozambique. Here, we used a combination of phylogenetic evidence, molecular dating and epidemiological reports to trace the origins and spread of subgenotype VIIh Newcastle disease in southern Africa. We determined that the infection spread northwards through Mozambique, and then into the poultry of the north-eastern provinces of Zimbabwe. From Mozambique, it also reached neighbouring Malawi and Zambia. In Zimbabwe, the disease spread southward towards South Africa and Botswana, causing outbreaks in backyard chickens in early-to-mid 2013. In August 2013, the disease entered South Africa's large commercial industry, and the entire country was infected within a year, likely through fomites and the movements of cull chickens. Illegal poultry trading or infected waste from ships and not wild migratory birds was the likely source of the introduction to Mozambique in 2011.
    MeSH terms: Africa, Southern/epidemiology; Animals; Animals, Wild; Chickens; Disease Outbreaks/veterinary*; DNA, Viral/genetics; Genotype; Newcastle Disease/epidemiology*; Newcastle Disease/virology; Newcastle disease virus/genetics; Newcastle disease virus/isolation & purification*; Phylogeny; Poultry; Poultry Diseases/epidemiology*; Poultry Diseases/virology; RNA, Viral/isolation & purification; Reverse Transcriptase Polymerase Chain Reaction/veterinary
  10. Low WZ, Khoo BE, Abdullah AFLB
    J Forensic Sci, 2018 Jul;63(4):1092-1098.
    PMID: 29178492 DOI: 10.1111/1556-4029.13702
    A new contactless technique for latent fingerprint visualization on nonporous curved surfaces of circular cross section was introduced by Low et al. (1). The technique utilizes a plane mirror to convey the light rays toward the inspected surfaces for latent fingerprint visualization. This research activity came up as an extension of the previous study which utilized an aluminum plate as the plane mirror to illuminate the inspected surfaces. Dulling spray was used to increase the diffuse component of the reflective aluminum plate. However, the amount of dulling spray will affect the uniformity of the illumination on the inspected curved surfaces. In this study, a study on the new materials for the plane mirror was carried out. Coated aluminum, opal, and ground glass diffusers were selected as the new materials. The performance of the new materials was compared to the aluminum based on the quality of the captured images on various nonporous cylindrical surfaces. A statistical approach known as randomized complete block design was used to design the experiment. The quality of the captured images was obtained using Spectral Image Validation and Verification. Two-way analysis of variance and Fisher's least significant difference test were used to analyze the quality of the images. From the results of the statistical analysis, coated aluminum has the best performance compared to aluminum, opal, and ground glass diffusers.
    MeSH terms: Aircraft; Aluminum; Analysis of Variance; Clothing; Diffusion; Glass; Lighting
  11. Mumtaz W, Saad MNBM, Kamel N, Ali SSA, Malik AS
    Artif Intell Med, 2018 01;84:79-89.
    PMID: 29169647 DOI: 10.1016/j.artmed.2017.11.002
    BACKGROUND: The abnormal alcohol consumption could cause toxicity and could alter the human brain's structure and function, termed as alcohol used disorder (AUD). Unfortunately, the conventional screening methods for AUD patients are subjective and manual. Hence, to perform automatic screening of AUD patients, objective methods are needed. The electroencephalographic (EEG) data have been utilized to study the differences of brain signals between alcoholics and healthy controls that could further developed as an automatic screening tool for alcoholics.

    METHOD: In this work, resting-state EEG-derived features were utilized as input data to the proposed feature selection and classification method. The aim was to perform automatic classification of AUD patients and healthy controls. The validation of the proposed method involved real-EEG data acquired from 30 AUD patients and 30 age-matched healthy controls. The resting-state EEG-derived features such as synchronization likelihood (SL) were computed involving 19 scalp locations resulted into 513 features. Furthermore, the features were rank-ordered to select the most discriminant features involving a rank-based feature selection method according to a criterion, i.e., receiver operating characteristics (ROC). Consequently, a reduced set of most discriminant features was identified and utilized further during classification of AUD patients and healthy controls. In this study, three different classification models such as Support Vector Machine (SVM), Naïve Bayesian (NB), and Logistic Regression (LR) were used.

    RESULTS: The study resulted into SVM classification accuracy=98%, sensitivity=99.9%, specificity=95%, and f-measure=0.97; LR classification accuracy=91.7%, sensitivity=86.66%, specificity=96.6%, and f-measure=0.90; NB classification accuracy=93.6%, sensitivity=100%, specificity=87.9%, and f-measure=0.95.

    CONCLUSION: The SL features could be utilized as objective markers to screen the AUD patients and healthy controls.

    MeSH terms: Adult; Aged; Alcoholism/diagnosis*; Alcoholism/physiopathology; Automation; Bayes Theorem; Brain/physiopathology*; Diagnosis, Computer-Assisted/methods*; Electroencephalography/methods*; Female; Humans; Male; Middle Aged; Predictive Value of Tests; ROC Curve; Signal Processing, Computer-Assisted*; Reproducibility of Results; Logistic Models; Case-Control Studies; Area Under Curve; Brain Waves*; Support Vector Machine*
  12. Ibrahim MKA, Hamid H, Law TH, Wong SV
    Accid Anal Prev, 2018 Feb;111:63-70.
    PMID: 29172046 DOI: 10.1016/j.aap.2017.10.023
    Construction of exclusive motorcycle lanes is one of the measures to reduce motorcycle fatalities. Previous studies highlighted the risk of crashes with roadside objects and the tendency of motorcyclists to ride with excessive speed on exclusive motorcycle lanes. However, the risk of same-direction crashes on exclusive motorcycle lanes was not explored in much detail, especially on the impact of lane geometry and roadside configurations. This study used naturalistic riding data to determine the effects of lane width and roadside configurations on overtaking speed, lateral position and likelihood of comfortable overtaking on tangential sections of an exclusive motorcycle lane. Twenty-nine recruited motorcyclists rode the instrumented motorcycles along a 20km stretch of an exclusive motorcycle lane along a major urban road. Results revealed that both the roadside configurations and lane width significantly affect the participants' lateral position, while the roadside configurations only affects the overtaking speed. Participants' overtaking speeds and the front motorcycles' lateral position contribute significantly to the likelihood of comfortable overtaking in exclusive motorcycle lanes. The findings highlight the importance of micro-level behavior indicators in improving the design and overall safety of the exclusive motorcycle facility.
    MeSH terms: Accidents, Traffic*; Adult; Environment Design*; Humans; Malaysia; Motorcycles*; Risk; Safety*; Young Adult
  13. Chow YP, Muhammad J, Amin Noordin BA, Cheng FF
    Data Brief, 2018 Feb;16:23-28.
    PMID: 29167816 DOI: 10.1016/j.dib.2017.11.015
    This data article provides macroeconomic data that can be used to generate macroeconomic volatility. The data cover a sample of seven selected countries in the Asia Pacific region for the period 2004-2014, including both developing and developed countries. This dataset was generated to enhance our understanding of the sources of macroeconomic volatility affecting the countries in this region. Although the Asia Pacific region continues to remain as the most dynamic part of the world's economy, it is not spared from various sources of macroeconomic volatility through the decades. The reported data cover 15 types of macroeconomic data series, representing three broad categories of indicators that can be used to proxy macroeconomic volatility. They are indicators that account for macroeconomic volatility (i.e. volatility as a macroeconomic outcome), domestic sources of macroeconomic volatility and external sources of macroeconomic volatility. In particular, the selected countries are Malaysia, Thailand, Indonesia and Philippines, which are regarded as developing countries, while Singapore, Japan and Australia are developed countries. Despite the differences in level of economic development, these countries were affected by similar sources of macroeconomic volatility such as the Asian Financial Crisis and the Global Financial Crisis. These countries were also affected by other similar external turbulence arising from factors such as the global economic slowdown, geopolitical risks in the Middle East and volatile commodity prices. Nonetheless, there were also sources of macroeconomic volatility which were peculiar to certain countries only. These were generally domestic sources of volatility such as political instability (for Thailand, Indonesia and Philippines), natural disasters and anomalous weather conditions (for Thailand, Indonesia, Philippines, Japan and Australia) and over-dependence on the electronic sector (for Singapore).
    MeSH terms: Australia; Developing Countries; Indonesia; Japan; Malaysia; Middle East; Philippines; Singapore; Thailand; Volatilization; Weather; Developed Countries; Economic Development
  14. Dossus L, Franceschi S, Biessy C, Navionis AS, Travis RC, Weiderpass E, et al.
    Int J Cancer, 2018 Apr 01;142(7):1332-1342.
    PMID: 29168186 DOI: 10.1002/ijc.31172
    Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1  = 0.69, 95% CI: 0.49-0.98, Ptrend  = 0.04) but not among men (ORT3vs.T1  = 1.36, 95% CI: 0.67-2.76, Ptrend  = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1  = 1.59, 95% CI: 1.13-2.25, Ptrend  = 0.01) but not in men (ORT3vs.T1  = 1.78, 95% CI: 0.80-3.98, Ptrend  = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
    MeSH terms: Adult; Aged; Female; Humans; Inflammation/blood; Male; Middle Aged; Prospective Studies; Risk Factors; Thyroid Neoplasms/blood*; Thyroid Neoplasms/epidemiology*; Biomarkers, Tumor/blood*; Interleukin-6/blood; Body Mass Index; Incidence; Case-Control Studies; Adiponectin/blood*; Adipokines/blood
  15. Sharma G, Ahmed HMA, Zilm PS, Rossi-Fedele G
    Aust Endod J, 2018 Apr;44(1):60-65.
    PMID: 29168274 DOI: 10.1111/aej.12216
    This review aims to evaluate the antimicrobial efficacy of calcium hydroxide against endodontic pathogens when used for 7 days or longer. A systematic electronic literature search was performed in the PubMed, Embase and EBSCO Dentistry & Oral Sciences Source databases using appropriate key words to identify investigations written in the English language that examined the association between the contact time of intracanal calcium hydroxide dressing and its antimicrobial properties. There were no exclusions based on study design. The search yielded 6993 publications. After duplicate removal, 5913 publications were identified and 11 studies met the inclusion criteria. Results showed that the antimicrobial effect of calcium hydroxide for contact times ranging between seven and 45 days is comparable. Two studies demonstrated contradictory findings when exposure was extended to more than 45 days. Future studies are warranted to investigate and optimise calcium hydroxide application for longer periods and identify the potential benefits of its use in clinical settings.
  16. Thavagnanam S, Cheong SY, Chinna K, Nathan AM, de Bruyne JA
    J Paediatr Child Health, 2018 May;54(5):530-534.
    PMID: 29168911 DOI: 10.1111/jpc.13789
    AIM: Adenotonsillectomy is performed in children with recurrent tonsillitis or obstructive sleep apnoea. Children at risk of post-operative respiratory complications are recommended to be monitored in paediatric intensive care unit (PICU). The aim of the study is to review the risk factors for post-operative complications and admissions to PICU.

    METHODS: A review of medical records of children who underwent adenotonsillectomy between January 2011 and December 2014 was performed. Association between demographic variables and post-operative complications were examined using chi-square and Mann-Whitney tests.

    RESULTS: A total of 214 children were identified, and of these, 19 (8.8%) experienced post-operative complications. Six children (2.8%) had respiratory complications: hypoxaemia in four and laryngospasm requiring reintubation in a further two. Both of the latter patients were extubated upon arrival to PICU and required no escalation of therapy. A total of 13 (6.1%) children had non-respiratory complications: 8 (3.7%) had infection and 5 (2.3%) had haemorrhage. A total of 26 (12.1%) children were electively admitted to PICU and mean stay was 19.5 (SD ± 13) h. No association between demographic characteristics, comorbid conditions or polysomnographic parameters and post-operative complications were noted. A total of 194 (90.7%) children stayed only one night in hospital (median 1 day, range 1-5 days).

    CONCLUSION: The previously identified risk factors and criteria for PICU admission need revision, and new recommendations are necessary.

    MeSH terms: Adenoidectomy*; Adolescent; Child; Child, Preschool; Female; Humans; Male; Patient Admission/statistics & numerical data; Postoperative Complications/diagnosis; Postoperative Complications/etiology*; Postoperative Complications/therapy; Respiratory Tract Diseases/diagnosis; Respiratory Tract Diseases/etiology*; Respiratory Tract Diseases/therapy; Retrospective Studies; Risk Factors; Tonsillectomy*; Intensive Care Units, Pediatric; Outcome Assessment (Health Care); Preoperative Period
  17. Buji RI, Abdul Murad NA, Chan LF, Maniam T, Mohd Shahrir MS, Rozita M, et al.
    Lupus, 2018 Apr;27(5):744-752.
    PMID: 29161964 DOI: 10.1177/0961203317742711
    Background Systemic lupus erythematosus (SLE) patients are a high-risk population for suicide. Glutamatergic neurosystem genes have been implicated in the neurobiology of depression in SLE and suicidal behaviour in general. However, the role of glutamate receptor gene polymorphisms in suicidal behaviour among SLE patients remains unclear in the context of established clinical and psychosocial factors. We aimed to investigate the association of NR2A gene polymorphism with suicidal ideation in SLE while accounting for the interaction between clinical and psychosocial factors. Methods A total of 130 SLE patients were assessed for mood disorders (MINI International Neuropsychiatric Interview), severity of depression (Patient Health Questionnaire-9), suicidal behaviour (Columbia-Suicide Severity Rating Scale), socio-occupational functioning (Work and Social Adjustment Scale), recent life events (Social Readjustment Rating Scale) and lupus disease activity (SELENA-SLE Disease Activity Index). Eighty-six out of the 130 study participants consented for NR2A genotyping. Results Multivariable logistic regression showed nominal significance for the interaction effect between the NR2A rs2072450 AC genotype and higher severity of socio-occupational impairment with lifetime suicidal ideation in SLE patients ( p = 0.038, odds ratio = 1.364, 95% confidence interval = 1.018-1.827). However, only the association between lifetime mood disorder and lifetime suicidal ideation remained significant after Bonferroni correction ( p 
    MeSH terms: Adolescent; Adult; Affect; Aged; Cross-Sectional Studies; Depression/diagnosis; Depression/genetics*; Depression/psychology*; Female; Hospitals, University; Humans; Inpatients; Lupus Erythematosus, Systemic/diagnosis; Lupus Erythematosus, Systemic/genetics*; Lupus Erythematosus, Systemic/psychology*; Malaysia; Male; Middle Aged; Outpatient Clinics, Hospital; Phenotype; Polymorphism, Genetic*; Risk Factors; Severity of Illness Index; Multivariate Analysis; Chi-Square Distribution; Logistic Models; Odds Ratio; Receptors, N-Methyl-D-Aspartate/genetics*; Genetic Predisposition to Disease; Young Adult; Suicidal Ideation*; Gene-Environment Interaction
  18. Bhatt P, Kumaresan V, Palanisamy R, Ravichandran G, Mala K, Amin SMN, et al.
    Fish Shellfish Immunol, 2018 Jan;72:670-678.
    PMID: 29162541 DOI: 10.1016/j.fsi.2017.11.036
    Chemokines are ubiquitous cytokine molecules involved in migration of cells during inflammation and normal physiological processes. Though the study on chemokines in mammalian species like humans have been extensively studied, characterization of chemokines in teleost fishes is still in the early stage. The present review provides an overview of chemokines and its receptors in a teleost fish, Channa striatus. C. striatus is an air breathing freshwater carnivore, which has enormous economic importance. This species is affected by an oomycete fungus, Aphanomyces invadans and a Gram negative bacteria Aeromonas hydrophila is known to cause secondary infection. These pathogens impose immune changes in the host organism, which in turn mounts several immune responses. Of these, the role of cytokines in the immune response is immense, due to their involvement in several activities of inflammation such as cell trafficking to the site of inflammation and antigen presentation. Given that importance, chemokines in fishes do have significant role in the immunological and other physiological functions of the organism, hence there is a need to understand the characteristics, activities and performace of these small molecules in details.
    MeSH terms: Animals; Fishes; Fresh Water; Fungi; Humans; Inflammation; Mammals; Physiological Phenomena; Cytokines; Aeromonas hydrophila; Antigen Presentation; Chemokines; Aphanomyces; Coinfection
  19. Yik YI, Hutson J, Southwell B
    Neuromodulation, 2018 Oct;21(7):676-681.
    PMID: 29164818 DOI: 10.1111/ner.12734
    BACKGROUND: Transcutaneous electrical stimulation (TES) for one to two months has produced some improvement in treatment-resistant slow-transit constipation (STC) in children. Optimal parameters for treatment are not known. It is possible that more improvement would occur with stimulation for longer. This study examined the effectiveness of stimulation for six months.

    METHODS: Children with STC confirmed by nuclear transit study (NTS) were enrolled prospectively. All had chronic constipation for greater than two years and had failed medical treatment. TES was performed for one hour/day for six months using the INF 4160 (Fuji Dynamics) portable stimulator and 4 cm × 4 cm electrodes near the belly button and on the back. Families kept bowel diaries and completed PEDSQLCore QOL (4.0) questionnaires before and at end of treatment.

    RESULTS: Sixty-two children (34 females; seven years, 2-16 year) with STC were studied. Defecation frequency increased in 57/62 (91%, mean ± SEM pre- 1.49 ± 0.20 vs. post- 3.25 ± 0.25 defecation/week, p 

    MeSH terms: Abdomen/innervation*; Adolescent; Age Factors; Child; Child, Preschool; Constipation/therapy*; Defecation/drug effects; Transcutaneous Electric Nerve Stimulation/methods*; Female; Follow-Up Studies; Gastrointestinal Transit/physiology; Home Care Services*; Humans; Male; Surveys and Questionnaires; Retrospective Studies; Physical Therapy Modalities; Laxatives/therapeutic use
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