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Exosomal mediated signal transduction through artificial microRNA (amiRNA): A potential target for inhibition of SARS-CoV-2

Vadivalagan C 1 , Shitut A 2 , Kamalakannan S 3 , Chen RM 4 , Serrano-Aroca Á 5 , Mishra V 6 Show all authors , Aljabali AAA 7 , Singh SK 8 , Chellappan DK 9 , Gupta G 10 , Dua K 11 , El-Tanani M 12 , Tambuwala MM 13 , Krishnan A 14

Affiliations 

  • 1 Graduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei 110, Taiwan; Department of Biochemistry, AKFA Medical School, AKFA University, Tashkent, Uzbekistan. Electronic address: marinedrug.9@gmail.com
  • 2 Department of Life Sciences, Christ University, Bhavani, Nagar, Bangalor, Karnataka 560029, India. Electronic address: anushka.shitut@science.christuniversity.in
  • 3 National Center for Disease Control, Ministry of Health and Family Welfare, Government of India, New Delhi 110054, India
  • 4 Graduate Institute of Medical Sciences, College of medicine, Taipei Medical University, Taipei 110, Taiwan
  • 5 Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain
  • 6 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India
  • 7 Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid 21163, Jordan
  • 8 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
  • 9 School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
  • 10 School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, India
  • 11 School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia
  • 12 Pharmacological and Diagnostic Research Centre, Al-Ahliyya Amman University, Faculty of Pharmacy, Amman, Jordan
  • 13 School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, United Kingdom. Electronic address: m.tambuwala@ulster.ac.uk
  • 14 Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa; Department of Chemical Pathology, School of Pathology, National Health Laboratory Services, Bloemfontein, South Africa. Electronic address: organicanand@gmail.com
Cell Signal, 2022 Jul;95:110334.
PMID: 35461900 DOI: 10.1016/j.cellsig.2022.110334

Abstract

Exosome trans-membrane signals provide cellular communication between the cells through transport and/or receiving the signal by molecule, change the functional metabolism, and stimulate and/or inhibit receptor signal complexes. COVID19 genetic transformations are varied in different geographic positions, and single nucleotide polymorphic lineages were reported in the second waves due to the fast mutational rate and adaptation. Several vaccines were developed and in treatment practice, but effective control has yet to reach in cent presence. It was initially a narrow immune-modulating protein target. Controlling these diverse viral strains may inhibit their transuding mechanisms primarily to target RNA genes responsible for COVID19 transcription. Exosomal miRNAs are the main sources of transmembrane signals, and trans-located miRNAs can directly target COVID19 mRNA transcription. This review discussed targeted viral transcription by delivering the artificial miRNA (amiRNA) mediated exosomes in the infected cells and significant resources of exosome and their efficacy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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