A review on taste masked multiparticulate dosage forms for paediatric

Al-Japairai K 1 , Hamed Almurisi S 2 , Almonem Doolaanea A 3 , Mahmood S 4 , Alheibshy F 5 , Alobaida A 6 Show all authors , Abdul-Halim N 7 , Chatterjee B 8

Affiliations 

  • 1 Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, Gambang 26300, Malaysia. Electronic address: PTP19001@stdmail.ump.edu.my
  • 2 Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Malaysia. Electronic address: samahhamed8611@gmail.com
  • 3 Department of Pharmaceutical Technology, Faculty of Pharmacy, Kolej Universiti Antarabangsa Maiwp (UCMI), Taman Batu Muda, Batu Caves, 68100 Kuala Lumpur, Malaysia. Electronic address: abdalmonemdoolaanea@yahoo.com
  • 4 Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia. Electronic address: syedmahmood@um.edu.my
  • 5 Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, Aden University, Aden 6075, Yemen. Electronic address: fa.alheibshy@uoh.edu.sa
  • 6 Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia. Electronic address: a.alobaida@uoh.edu.sa
  • 7 Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, Gambang 26300, Malaysia. Electronic address: nadiya@ump.edu.my
  • 8 SPP School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, India. Electronic address: Bappaditya.chatterjee@nmims.edu
Int J Pharm, 2023 Feb 05;632:122571.
PMID: 36587776 DOI: 10.1016/j.ijpharm.2022.122571

Abstract

Taste refers to those sensations perceived through taste buds on the tongue and oral cavity. The unpleasant taste of drugs leads to the refusal of taking the medicine in the paediatric population. It is widely known that a pharmaceutical product's general acceptability is the result of numerous contributing components such as swallowability, palatability (taste, flavour, texture, and mouthfeel), appearance, ease of administration, and patient characteristics. Multiparticulate as a dosage form is a platform technology for overcoming paediatrics' incapacity to swallow monolithic dosage forms, masking many medications' inherent nasty taste, and overcoming the obstacles of manufacturing a commercially taste masked dosage form. This review will discuss the considerations that must be taken into account to prepare taste masked multiparticulate dosage forms in the best way for paediatric use.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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