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Predicting the potential for zoonotic transmission and host associations for novel viruses

Pandit PS 1 , Anthony SJ 2 , Goldstein T 3 , Olival KJ 4 , Doyle MM 3 , Gardner NR 3 Show all authors , Bird B 3 , Smith W 3 , Wolking D 3 , Gilardi K 3 , Monagin C 3 , Kelly T 3 , Uhart MM 3 , Epstein JH 4 , Machalaba C 4 , Rostal MK 4 , Dawson P 4 , Hagan E 4 , Sullivan A 4 , Li H 4 , Chmura AA 4 , Latinne A 4 , Lange C 5 , O'Rourke T 5 , Olson S 6 , Keatts L 3 , Mendoza AP 6 , Perez A 7 , de Paula CD 6 , Zimmerman D 8 , Valitutto M 8 , LeBreton M 9 , McIver D 10 , Islam A 4 , Duong V 11 , Mouiche M 9 , Shi Z 12 , Mulembakani P 13 , Kumakamba C 14 , Ali M 15 , Kebede N 16 , Tamoufe U 17 , Bel-Nono S 18 , Camara A 19 , Pamungkas J 20 , Coulibaly KJ 21 , Abu-Basha E 22 , Kamau J 23 , Silithammavong S 10 , Desmond J 4 , Hughes T 4 , Shiilegdamba E 24 , Aung O 8 , Karmacharya D 25 , Nziza J 26 , Ndiaye D 27 , Gbakima A 28 , Sajali Z 29 , Wacharapluesadee S 30 , Robles EA 31 , Ssebide B 26 , Suzán G 32 , Aguirre LF 33 , Solorio MR 34 , Dhole TN 35 , Nga NTT 36 , Hitchens PL 37 , Joly DO 38 , Saylors K 5 , Fine A 6 , Murray S 9 , Karesh WB 4 , Daszak P 4 , Mazet JAK 3 , PREDICT Consortium , Johnson CK 39

Affiliations 

  • 1 One Health Institute, School of Veterinary Medicine, University of California, Davis, Davis, CA, 95616, USA. pspandit@ucdavis.edu
  • 2 Center for Infection and Immunity, Columbia University, New York, NY, 10032, USA
  • 3 One Health Institute, School of Veterinary Medicine, University of California, Davis, Davis, CA, 95616, USA
  • 4 EcoHealth Alliance, 520 Eighth Avenue, New York, NY, 10018, USA
  • 5 Labyrinth Global Health, Inc., 546 15th Ave NE, St Petersburg, FL, 33704, USA
  • 6 Wildlife Conservation Society, Health Program, Bronx, NY, USA
  • 7 Wildlife Conservation Society (WCS), Peru Program, Lima, Peru
  • 8 Global Health Program, Smithsonian's National Zoological Park and Conservation Biology Institute, Washington, DC, USA
  • 9 Mosaic/Global Viral Cameroon, Yaoundé, Cameroon
  • 10 Metabiota Inc, Nanaimo, VC, Canada
  • 11 Institut Pasteur du Cambodge, 5 Monivong Blvd, PO Box 983, Phnom Penh, 12201, Cambodia
  • 12 Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
  • 13 Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
  • 14 Metabiota Inc., Kinshasa, Democratic Republic of the Congo
  • 15 Egypt National Research Centre, 12311, Dokki, Giza, Egypt
  • 16 Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
  • 17 Metabiota Cameroon Ltd, Yaoundé, Centre Region Avenue Mvog-Fouda Ada, Av 1.085, Carrefour Intendance, Yaoundé, BP, 15939, Cameroon
  • 18 Military Veterinarian (Rtd.), P.O. Box CT2585, Accra, Ghana
  • 19 Centre de Recherche en Virologie (VRV) Projet Fievres Hemoraquiques en Guinée, BP, 5680, Nongo/Contéya-Commune de Ratoma, Guinea
  • 20 Primate Research Center, Bogor Agricultural University, Bogor, 16151, Indonesia
  • 21 Department Environment and Health, Institut Pasteur de Côte d'Ivoire, PO BOX 490, Abidjan 01, Ivory Coast
  • 22 Department of Basic Medical Veterinary Sciences, College of Veterinary Medicine, Jordan University of Science and Technology, Ar-Ramtha, Jordan
  • 23 Molecular Biology Laboratory, Institute of Primate Research, Nairobi, Kenya
  • 24 Wildlife Conservation Society (WCS), Mongolia Program, Ulaanbaatar, Mongolia
  • 25 Center for Molecular Dynamics Nepal (CMDN), Thapathali -11, Kathmandu, Nepal
  • 26 Regional Headquarters, Mountain Gorilla Veterinary Project, Musanze, Rwanda
  • 27 Université Cheikh Anta Diop, BP 5005, Dakar, Sénégal
  • 28 Metabiota, Inc. Sierra Leone, Freetown, Sierra Leone
  • 29 Department of Veterinary Medicine and Public Health, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania
  • 30 Thai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
  • 31 Wildlife Conservation Society (WCS), Bolivia Program, La Paz, Bolivia
  • 32 Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México City, 04510, Mexico
  • 33 Centro de Biodiversidad y Genética, Universidad Mayor de San Simón, Cochabamba, Bolivia
  • 34 Laboratório de Epidemiologia e Geoprocessamento (EpiGeo), Instituto de Medicina Veterinária (IMV) Universidade Federal do Pará (UFPA), BR-316 Km 31, Castanhal, Pará, 69746-360, Brazil
  • 35 Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  • 36 Wildlife Conservation Society (WCS), Vietnam Program, Hanoi, Vietnam
  • 37 Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, VIC, 3030, Australia
  • 38 Nyati Health Consulting, 2175 Dodds Road, Nanaimo, V9X0A4, Canada
  • 39 One Health Institute, School of Veterinary Medicine, University of California, Davis, Davis, CA, 95616, USA. ckjohnson@ucdavis.edu
Commun Biol, 2022 Aug 19;5(1):844.
PMID: 35986178 DOI: 10.1038/s42003-022-03797-9

Abstract

Host-virus associations have co-evolved under ecological and evolutionary selection pressures that shape cross-species transmission and spillover to humans. Observed virus-host associations provide relevant context for newly discovered wildlife viruses to assess knowledge gaps in host-range and estimate pathways for potential human infection. Using models to predict virus-host networks, we predicted the likelihood of humans as hosts for 513 newly discovered viruses detected by large-scale wildlife surveillance at high-risk animal-human interfaces in Africa, Asia, and Latin America. Predictions indicated that novel coronaviruses are likely to infect a greater number of host species than viruses from other families. Our models further characterize novel viruses through prioritization scores and directly inform surveillance targets to identify host ranges for newly discovered viruses.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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