Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway

Jamal J 1 , Mustafa MR 1 , Wong PF 2

Affiliations 

  • 1 Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: wongpf@um.edu.my
J Ethnopharmacol, 2014 Jun 11;154(2):428-36.
PMID: 24768807 DOI: 10.1016/j.jep.2014.04.025

Abstract

Paeonol is a phenolic compound isolated mainly from Moutan cortex, root bark of Chinese Peony tree. Moutan cortex holds a significant value in traditional Chinese medicine for alleviating various oxidative stress-related diseases mainly atherosclerosis and myocardial infarction. The present study seeks to identify the protective mechanisms of paeonol in oxidative stress-induced premature senescence in endothelial cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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