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Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Liu S 1 , Claude H 2 , Yong SJ 3 , Chen D 4

Affiliations 

  • 1 Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, Ontario, Canada. Shiliang.liu@phac-aspc.gc.ca
  • 2 Reproductive Health Center of Excellence and Therapeutic Science and Strategy Unit, IQVIA & Department of OB-GYN, Duke University Medical Center, Durham, NC, USA
  • 3 Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia
  • 4 Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Sci Rep, 2023 May 09;13(1):7540.
PMID: 37161036 DOI: 10.1038/s41598-023-34090-2

Abstract

Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004-2020. We used "winter" months (i.e., September through June) and northern areas of residence as indicators of less sunlight/less active lifestyle, while "summer" (i.e., July and August) and southern areas were considered as reference. Rate of gastroschisis for infants conceived in winter (3.4 per 10,000) was higher than for infants conceived in summer (2.2 per 10,000; p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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