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Dengue virus type 2 (DENV2)-induced oxidative responses in monocytes from glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD normal subjects

Al-Alimi AA 1 , Ali SA 1 , Al-Hassan FM 1 , Idris FM 2 , Teow SY 1 , Mohd Yusoff N 1

Affiliations 

  • 1 Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia
  • 2 Department of Microbiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
PLoS Negl Trop Dis, 2014 Mar;8(3):e2711.
PMID: 24625456 DOI: 10.1371/journal.pntd.0002711

Abstract

Dengue virus is endemic in peninsular Malaysia. The clinical manifestations vary depending on the incubation period of the virus as well as the immunity of the patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Malaysia where the incidence is 3.2%. It has been noted that some G6PD-deficient individuals suffer from more severe clinical presentation of dengue infection. In this study, we aim to investigate the oxidative responses of DENV2-infected monocytes from G6PD-deficient individuals.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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