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Facile synthesis of elastin nanogels encapsulated decursin for castrated resistance prostate cancer therapy

Rather GA 1 , Selvakumar P 1 , Srinivas KS 2 , Natarajan K 3 , Kaushik A 4 , Rajan P 5 Show all authors , Lee SR 6 , Sing WL 7 , Alkhamees M 8 , Lian S 9 , Holley M 10 , Do Jung Y 11 , Lakshmanan VK 12

Affiliations 

  • 1 Prostate Cancer Biomarker Laboratory, Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, 600116, India
  • 2 Department of Radiation Oncology, Faculty of Medicine, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, 600 116, India
  • 3 Department of Urology, Faculty of Medicine, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, 600 116, India
  • 4 NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, Lakeland, FL, USA
  • 5 Centre for Cancer Cell and Molecular Biology, Cancer Research, Barts Cancer Institute, UK City of London Centre, Charterhouse Square, London, EC1M 6BQ, UK
  • 6 Department of Biochemistry, Chonnam National University Medical School, Seoyang Ro 264, Hwasun, 58128, Korea
  • 7 Faculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN Putra Nilai, 71800, Nilai, Negeri Sembilan, Malaysia
  • 8 Department of Urology, College of Medicine, Majmaah University, 11952, Al Majmaah, Saudi Arabia
  • 9 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
  • 10 International Hyperbaric Medical Foundation, The Tissue & Organ Regeneration Institute, Greater New Orleans, USA
  • 11 Department of Biochemistry, Chonnam National University Medical School, Seoyang Ro 264, Hwasun, 58128, Korea. ydjung@chonnam.ac.kr
  • 12 Prostate Cancer Biomarker Laboratory, Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education & Research, Porur, Chennai, 600116, India. vinoth.lakshmanan@sriramachandra.edu.in
Sci Rep, 2024 Jul 02;14(1):15095.
PMID: 38956125 DOI: 10.1038/s41598-024-65999-x

Abstract

Nanogels offer hope for precise drug delivery, while addressing drug delivery hurdles is vital for effective prostate cancer (PCa) management. We developed an injectable elastin nanogels (ENG) for efficient drug delivery system to overcome castration-resistant prostate cancer (CRPC) by delivering Decursin, a small molecule inhibitor that blocks Wnt/βcatenin pathways for PCa. The ENG exhibited favourable characteristics such as biocompatibility, flexibility, and low toxicity. In this study, size, shape, surface charge, chemical composition, thermal stability, and other properties of ENG were used to confirm the successful synthesis and incorporation of Decursin (DEC) into elastin nanogels (ENG) for prostate cancer therapy. In vitro studies demonstrated sustained release of DEC from the ENG over 120 h, with a pH-dependent release pattern. DU145 cell line induces moderate cytotoxicity of DEC-ENG indicates that nanomedicine has an impact on cell viability and helps strike a balance between therapeutics efficacy and safety while the EPR effect enables targeted drug delivery to prostate tumor sites compared to free DEC. Morphological analysis further supported the effectiveness of DEC-ENG in inducing cell death. Overall, these findings highlight the promising role of ENG-encapsulated decursin as a targeted drug delivery system for CRPC.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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