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Multicentre case-control study of pneumococcal infections among children with pneumonia in Peninsular Malaysia (MY-Pneumo): a study protocol

Ramzi NH 1 , Hoong ATC 2 , Johari NA 2 , Nathan AM 3 , Teh CSJ 4 , Sulaiman NA 3 Show all authors , Ilias MI 5 , Deris ZZ 6 , Hazlan SNH 6 , Nasir NSM 6 , Bakar AA 7 , Helmi MAM 7 , Juhari WKW 7 , Kamarudin N 8 , Chong CW 2 , Cleary DW 9 , Clarke SC 2 , Sulaiman LH 2

Affiliations 

  • 1 Institute for Research, Development and Innovation, IMU University (formerly known as International Medical University), Kuala Lumpur, 57000, Malaysia. nurulhanis@imu.edu.my
  • 2 Institute for Research, Development and Innovation, IMU University (formerly known as International Medical University), Kuala Lumpur, 57000, Malaysia
  • 3 Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 4 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 5 Department of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, 16150, Malaysia
  • 6 Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, 16150, Malaysia
  • 7 Department of Paediatric, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia
  • 8 Department of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, 25200, Malaysia
  • 9 Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
BMC Public Health, 2024 Aug 20;24(1):2255.
PMID: 39164673 DOI: 10.1186/s12889-024-19789-9

Abstract

BACKGROUND: S. pneumoniae (SPN) is the most common cause of pneumonia. The disease can be effectively prevented through immunisation. Since December 2020, the Malaysian Government has included the 10-valent pneumococcal conjugate vaccine (PCV10) for all infants born on or after 1 January 2020 as part of the National Immunisation Programme (NIP). However, the epidemiology of pneumonia remains poorly understood. To fill the knowledge gap, we established a multicentre surveillance study to understand the burden of pneumococcal pneumonia among young children in Peninsular Malaysia.

METHODS: MY-Pneumo is a multicentre prospective case-control study conducted in three sentinel sites located in three different states of Peninsular Malaysia - Kuala Lumpur, Pahang, and Kelantan. A cohort of at least 500 incident cases and 500 controls is enrolled beginning in October 2021 and matched for age. Cases are hospitalised children 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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