Randomized single-blinded study comparing sedation effectiveness and hemodynamic stability of remifentanil vs dexmedetomidine infusion for electrophysiology procedures in patients of National Heart Institute cathlab

Hassan R; Mutalib AA; Shang CY; Sachdev NS; Rahman FA; Ling ESL

doi:10.1007/s10840-024-01884-x

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Randomized single-blinded study comparing sedation effectiveness and hemodynamic stability of remifentanil vs dexmedetomidine infusion for electrophysiology procedures in patients of National Heart Institute cathlab

Hassan R ¹ , Mutalib AA ² , Shang CY ² , Sachdev NS ² , Rahman FA ² , Ling ESL ²

Affiliations

¹ Anaesthesia Department, National Heart Institute, 145, Jalan Tun Razak, 50400, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. dr.rozaini@ijn.com.my
² Anaesthesia Department, National Heart Institute, 145, Jalan Tun Razak, 50400, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia

J Interv Card Electrophysiol, 2024 Nov;67(8):1735-1743.

PMID: 39110272 DOI: 10.1007/s10840-024-01884-x

Abstract

BACKGROUND: While studies comparing the effectiveness of remifentanil and dexmedetomidine are prevalent in other nations, using remifentanil alone is uncommon in Malaysia. This research aims to evaluate the effectiveness of sedation with remifentanil or dexmedetomidine infusion in monitored anesthesia care for electrophysiology procedures.

METHODS: This study is a single-center, single-blinded, prospective randomized clinical study. One hundred twenty patients were randomized into two groups (remifentanil vs dexmedetomidine). Demographic characteristics and clinical outcomes, including level of sedation, vital signs, and patient satisfaction were monitored and recorded.

RESULTS: Group R showed a higher mean observer's assessment of alertness/sedation score (3.9 ± 0.7 vs 3.6 ± 0.8; p = 0.008), mean arterial pressure (92.0 ± 12.0 vs 83.0 ± 13.0 mmHg; p

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