Effects of ranibizumab on microvasculature, oxidative stress and recurrence in primary pterygium surgery

Yap JY 1 , Tai ELM 2 , Kueh YC 3 , Salleh S 4 , Ibrahim M 2

Affiliations 

  • 1 Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia. yapjinyi@ums.edu.my
  • 2 Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia
  • 3 Biostatistics and Research Methodology Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia
  • 4 Department of Pathology, Hospital USM, Health Campus, USM, 16150, Kubang Kerian, Kelantan, Malaysia
Int Ophthalmol, 2025 Jan 20;45(1):29.
PMID: 39832029 DOI: 10.1007/s10792-024-03390-5

Abstract

PURPOSE: To evaluate the effects of pre-operative ranibizumab injection on microvascular density (MVD), 8-hydroxyguanosine (8-OHdG) and recurrence after surgical excision of primary pterygium.

METHOD: This was a prospective cohort interventional study involving 52 patients with primary pterygium divided equally into control and intervention groups. The intervention group received 0.5 mg ranibizumab two weeks prior to pterygium excision surgery. All participants had pterygium excision with autologous conjunctival graft under local anaesthesia. Excised pterygium tissues were evaluated for MVD and 8-OHdG. Each participant was monitored for recurrence up to 2 years after intervention. Pearson chi-square and Fisher exact tests were used to examine the differences between both groups.

RESULTS: The intervention group demonstrated significantly lower MVD (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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