The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran

Heidari MH 1 , Porghasem M 2 , Mirzaei N 3 , Mohseni JH 4 , Heidari M 5 , Azargashb E 6 Show all authors , Movafagh A 7 , Heidari R 8 , Molouki A 9 , Larijani L 10

Affiliations 

  • 1 Department of Anatomy and Biology, Proteomics Laboatory, Shahid Beheshti University of Medical Sciences, Velenjak, Tehran, Iran. Electronic address: hdr@sbmu.ac.ir
  • 2 Department of Anatomical Science, Babol University of Medical Sciences, Babol, Iran
  • 3 Emam Sajjad Hospital of Ramsar, Ramsar, Iran
  • 4 Mohseni Clinical Diagnostic Laboratory, Noshahr, Iran
  • 5 Medical School, Tehran University of Medical Sciences, Tehran, Iran
  • 6 Department of Health and Social Medical Researches, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 7 Department of Clinical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 8 Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • 9 Institute of Bioscience, University Putra Malaysia, Serdang, Selangor DE, Malaysia
  • 10 Department of Anatomy and Biology, Proteomics Laboatory, Shahid Beheshti University of Medical Sciences, Velenjak, Tehran, Iran
J Environ Radioact, 2014 Feb;128:64-7.
PMID: 24292395 DOI: 10.1016/j.jenvrad.2013.11.001

Abstract

Since several high level natural radiation areas (HLNRAs) exist on our planet, considerable attention has been drawn to health issues that may develop as the result of visiting or living in such places. City of Ramsar in Iran is an HNLRA, and is a tourist attraction mainly due to its hot spas. However, the growing awareness over its natural radiation sources has prompted widespread scientific investigation at national level. In this study, using an ELISA method, the level of expression of three tumor markers known as carcinoembryonic antigen (CEA), prostate-specific antigen (PSA) and carcino antigen 19-9 (CA19-9) in blood serum of 40 local men of Ramsar (subject group) was investigated and compared to 40 men from the city of Noshahr (control group). Noshahr was previously identified as a normal level natural radiation area (NLNRA) that is some 85 km far from Ramsar. According to statistical analysis, there was a significant difference in the levels of PSA and CA19-9 markers between the two groups (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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