Synthesis, spectral studies and biological evaluation of 2-aminonicotinic acid metal complexes

Nawaz M 1 , Abbasi MW 2 , Hisaindee S 3 , Zaki MJ 2 , Abbas HF 4 , Mengting H 5 Show all authors , Ahmed MA 6

Affiliations 

  • 1 Department of Nano-Medicine, Institute for Research and Medical Consultations, University of Dammam, Dammam, Saudi Arabia. Electronic address: nawwaz@gmail.com
  • 2 Department of Botany, University of Karachi, Karachi 75250, Pakistan
  • 3 Department of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab Emirates
  • 4 Department of Pharmacology, College of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 5 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China
  • 6 H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Spectrochim Acta A Mol Biomol Spectrosc, 2016 May 15;161:39-43.
PMID: 26945123 DOI: 10.1016/j.saa.2016.02.022

Abstract

We synthesized 2-aminonicotinic acid (2-ANA) complexes with metals such as Co(II), Fe(III), Ni(II), Mn(II), Zn(II), Ag(I),Cr(III), Cd(II) and Cu(II) in aqueous media. The complexes were characterized and elucidated using FT-IR, UV-Vis, a fluorescence spectrophotometer and thermo gravimetric analysis (TGA). TGA data showed that the stoichiometry of complexes was 1:2 metal/ligand except for Ag(I) and Mn(II) where the ratio was 1:1. The metal complexes showed varied antibacterial, fungicidal and nematicidal activities. The silver and zinc complexes showed highest activity against Bacillus subtilis and Bacillus licheniformis respectively. Fusarium oxysporum was highly susceptible to nickel and copper complexes whereas Macrophomina phaseolina was completely inert to the complexes. The silver and cadmium complexes were effective against the root-knot nematode Meloidogyne javanica.

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