• 1 Faculty of Medicine, University Hospital, Kuala Lumpur
  • 2 Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur
  • 3 Medical Department, Astra Pharmaceutical, Jalan Dungun, Kuala Lumpur
Med J Malaysia, 1992 Dec;47(4):290-6.
PMID: 1303482


In a single-blind study conducted at our centres, 78 hypertensive patients were enrolled with 58 completing the study according to the protocol. Mean supine and standing blood pressures were significantly reduced after treatment with felodipine, reductions being 27/21 mmHg (p < 0.0001) and 25/19 mmHg (p < 0.0001) respectively. Of 46 patients given felodipine 5 mg, 44 (95.7%) achieved target blood pressure defined as a diastolic blood pressure of < 90 mmHg, while all 12 patients on felodipine 10 mg did so. The 2 patients who did not achieve target pressure at the final visit did so on previous visits. There were no differences in pre and post-treatment laboratory variables. Treatment was discontinued in 6 patients because of headaches. No adverse events of clinical significance were reported in the 58 patients who completed the study. In conclusion, we found felodipine given once daily to be effective in the treatment of mild to moderate hypertension.

Study site: Multicentre

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.