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Antioxidant and cytotoxic activities of three species of tropical seaweeds

Chia YY 1 , Kanthimathi MS 2 , Khoo KS 3 , Rajarajeswaran J 4 , Cheng HM 5 , Yap WS 6

Affiliations 

  • 1 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. gracechia1986@hotmail.com
  • 2 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. kanthi@ummc.edu.my
  • 3 Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman (Kampar campus), Jalan Universiti, Bandar Barat, 31900, Kampar, Perak, Malaysia. khooks@utar.edu.my
  • 4 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. jayakumar7979@gmail.com
  • 5 Department of Physiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. chenghm@ummc.edu.my
  • 6 Department of Biotechnology, Faculty of Applied Sciences, UCSI University, 56000 UCSI Heights, Kuala Lumpur, Malaysia. wsyap@ucsi.edu.my
BMC Complement Altern Med, 2015;15:339.
PMID: 26415532 DOI: 10.1186/s12906-015-0867-1

Abstract

Three species of seaweeds (Padina tetrastromatica, Caulerpa racemosa and Turbinaria ornata) are widely consumed by Asians as nutraceutical food due to their antioxidant properties. Studies have shown that these seaweeds exhibit bioactivities which include antimicrobial, antiviral, anti-hypertensive and anticoagulant activities. However, investigations into the mechanisms of action pertaining to the cytotoxic activity of the seaweeds are limited. The aim of this study was to determine the antioxidant and cytotoxic activities of whole extracts of P. tetrastromatica, C. racemosa and T. ornata, including the cellular events leading to the apoptotic cell death of the extract treated-MCF-7 cells. Bioassay guided fractionation was carried out and the compounds identified.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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