Clinical Relevance of MTHFR, eNOS, ACE, and ApoE Gene Polymorphisms and Serum Vitamin Profile among Malay Patients with Ischemic Stroke

Wei LK 1 , Au A 2 , Menon S 3 , Gan SH 2 , Griffiths LR 3

Affiliations 

  • 1 Centre for Biodiversity Research, Universiti Tunku Abdul Rahman, Perak, Malaysia; Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak, Malaysia; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia; Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. Electronic address: wynnelkw@gmail.com
  • 2 Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • 3 Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
J Stroke Cerebrovasc Dis, 2015 Sep;24(9):2017-25.
PMID: 26187788 DOI: 10.1016/j.jstrokecerebrovasdis.2015.04.011

Abstract

The purpose of this study was threefold. First, it was to determine the relationship between serum vitamin profiles and ischemic stroke. The second purpose was to investigate the association of methylenetetrahydrofolate reductase (MTHFR), endothelial nitric oxide synthase (eNOS), angiotensin converting enzyme (ACE), and apolipoprotein-E (ApoE) gene polymorphisms with ischemic stroke and further correlate with serum vitamin profiles among ischemic stroke patients. The third purpose of the study was to highlight the interaction of MTHFR and eNOS haplotypes with serum vitamin profiles and ischemic stroke risks.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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