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Evolution of Influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and 2008

Sam IC 1 , Su YC 2 , Chan YF 3 , Nor'E SS 4 , Hassan A 3 , Jafar FL 3 Show all authors , Joseph U 2 , Halpin RA 5 , Ghedin E 6 , Hooi PS 7 , Fourment M 8 , Hassan H 3 , AbuBakar S 4 , Wentworth DE 5 , Smith GJ 9

Affiliations 

  • 1 Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg
  • 2 Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore
  • 3 Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
  • 4 Tropical Infectious Diseases Research and Education Centre, University Malaya, Kuala Lumpur, Malaysia
  • 5 J. Craig Venter Institute, Rockville, Maryland, USA
  • 6 Department of Biology, Center for Genomics & Systems Biology, and Global Institute of Public Health, New York University, New York, New York, USA
  • 7 Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia
  • 8 Duke Global Health Institute, Duke University, Durham, North Carolina, USA
  • 9 Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore Duke Global Health Institute, Duke University, Durham, North Carolina, USA jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg
J Virol, 2015 Sep;89(18):9689-92.
PMID: 26136576 DOI: 10.1128/JVI.00708-15

Abstract

Influenza B virus causes significant disease but remains understudied in tropical regions. We sequenced 72 influenza B viruses collected in Kuala Lumpur, Malaysia, from 1995 to 2008. The predominant circulating lineage (Victoria or Yamagata) changed every 1 to 3 years, and these shifts were associated with increased incidence of influenza B. We also found poor lineage matches with recommended influenza virus vaccine strains. While most influenza B virus lineages in Malaysia were short-lived, one circulated for 3 to 4 years.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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