Fulltext

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Phelan CM 1 , Kuchenbaecker KB 2 , Tyrer JP 3 , Kar SP 3 , Lawrenson K 4 , Winham SJ 5 Show all authors , Dennis J 3 , Pirie A 3 , Riggan MJ 6 , Chornokur G 1 , Earp MA 7 , Lyra PC 1 , Lee JM 8 , Coetzee S 8 , Beesley J 9 , McGuffog L 10 , Soucy P 11 , Dicks E 3 , Lee A 10 , Barrowdale D 10 , Lecarpentier J 10 , Leslie G 10 , Aalfs CM 12 , Aben KKH 13 , Adams M 14 , Adlard J 15 , Andrulis IL 16 , Anton-Culver H 17 , Antonenkova N 18 , AOCS study group , Aravantinos G 19 , Arnold N 20 , Arun BK 21 , Arver B 22 , Azzollini J 23 , Balmaña J 24 , Banerjee SN 25 , Barjhoux L 26 , Barkardottir RB 27 , Bean Y 28 , Beckmann MW 29 , Beeghly-Fadiel A 30 , Benitez J 31 , Bermisheva M 32 , Bernardini MQ 33 , Birrer MJ 34 , Bjorge L 35 , Black A 36 , Blankstein K 37 , Blok MJ 38 , Bodelon C 36 , Bogdanova N 39 , Bojesen A 40 , Bonanni B 41 , Borg Å 42 , Bradbury AR 43 , Brenton JD 44 , Brewer C 45 , Brinton L 36 , Broberg P 46 , Brooks-Wilson A 47 , Bruinsma F 48 , Brunet J 49 , Buecher B 50 , Butzow R 51 , Buys SS 52 , Caldes T 53 , Caligo MA 54 , Campbell I 55 , Cannioto R 56 , Carney ME 57 , Cescon T 37 , Chan SB 58 , Chang-Claude J 59 , Chanock S 36 , Chen XQ 9 , Chiew YE 60 , Chiquette J 61 , Chung WK 62 , Claes KBM 63 , Conner T 52 , Cook LS 64 , Cook J 65 , Cramer DW 66 , Cunningham JM 67 , D'Aloisio AA 68 , Daly MB 69 , Damiola F 26 , Damirovna SD 70 , Dansonka-Mieszkowska A 71 , Dao F 72 , Davidson R 73 , DeFazio A 60 , Delnatte C 74 , Doheny KF 14 , Diez O 75 , Ding YC 76 , Doherty JA 77 , Domchek SM 43 , Dorfling CM 78 , Dörk T 79 , Dossus L 80 , Duran M 81 , Dürst M 82 , Dworniczak B 83 , Eccles D 84 , Edwards T 30 , Eeles R 85 , Eilber U 59 , Ejlertsen B 86 , Ekici AB 87 , Ellis S 10 , Elvira M 70 , EMBRACE Study , Eng KH 88 , Engel C 89 , Evans DG 90 , Fasching PA 29 , Ferguson S 33 , Ferrer SF 91 , Flanagan JM 92 , Fogarty ZC 5 , Fortner RT 59 , Fostira F 93 , Foulkes WD 94 , Fountzilas G 95 , Fridley BL 96 , Friebel TM 97 , Friedman E 98 , Frost D 10 , Ganz PA 99 , Garber J 100 , García MJ 31 , Garcia-Barberan V 53 , Gehrig A 101 , GEMO Study Collaborators , Gentry-Maharaj A 102 , Gerdes AM 103 , Giles GG 48 , Glasspool R 104 , Glendon G 105 , Godwin AK 106 , Goldgar DE 107 , Goranova T 44 , Gore M 108 , Greene MH 109 , Gronwald J 110 , Gruber S 111 , Hahnen E 112 , Haiman CA 113 , Håkansson N 114 , Hamann U 115 , Hansen TVO 116 , Harrington PA 3 , Harris HR 114 , Hauke J 112 , HEBON Study , Hein A 29 , Henderson A 117 , Hildebrandt MAT 118 , Hillemanns P 119 , Hodgson S 120 , Høgdall CK 121 , Høgdall E 122 , Hogervorst FBL 123 , Holland H 9 , Hooning MJ 124 , Hosking K 3 , Huang RY 125 , Hulick PJ 126 , Hung J 60 , Hunter DJ 127 , Huntsman DG 128 , Huzarski T 110 , Imyanitov EN 129 , Isaacs C 130 , Iversen ES 131 , Izatt L 132 , Izquierdo A 49 , Jakubowska A 110 , James P 133 , Janavicius R 134 , Jernetz M 135 , Jensen A 122 , Jensen UB 136 , John EM 137 , Johnatty S 9 , Jones ME 138 , Kannisto P 135 , Karlan BY 4 , Karnezis A 128 , Kast K 139 , KConFab Investigators , Kennedy CJ 60 , Khusnutdinova E 32 , Kiemeney LA 13 , Kiiski JI 140 , Kim SW 141 , Kjaer SK 121 , Köbel M 142 , Kopperud RK 35 , Kruse TA 143 , Kupryjanczyk J 71 , Kwong A 144 , Laitman Y 98 , Lambrechts D 145 , Larrañaga N 146 , Larson MC 5 , Lazaro C 147 , Le ND 148 , Le Marchand L 149 , Lee JW 150 , Lele SB 151 , Leminen A 140 , Leroux D 152 , Lester J 4 , Lesueur F 153 , Levine DA 72 , Liang D 154 , Liebrich C 155 , Lilyquist J 156 , Lipworth L 30 , Lissowska J 157 , Lu KH 158 , Lubinński J 110 , Luccarini C 3 , Lundvall L 159 , Mai PL 109 , Mendoza-Fandiño G 1 , Manoukian S 23 , Massuger LFAG 13 , May T 33 , Mazoyer S 160 , McAlpine JN 161 , McGuire V 162 , McLaughlin JR 163 , McNeish I 164 , Meijers-Heijboer H 165 , Meindl A 166 , Menon U 102 , Mensenkamp AR 167 , Merritt MA 168 , Milne RL 48 , Mitchell G 133 , Modugno F 169 , Moes-Sosnowska J 71 , Moffitt M 170 , Montagna M 171 , Moysich KB 56 , Mulligan AM 172 , Musinsky J 173 , Nathanson KL 43 , Nedergaard L 174 , Ness RB 175 , Neuhausen SL 76 , Nevanlinna H 140 , Niederacher D 176 , Nussbaum RL 177 , Odunsi K 151 , Olah E 178 , Olopade OI 179 , Olsson H 46 , Olswold C 156 , O'Malley DM 180 , Ong KR 181 , Onland-Moret NC 182 , OPAL study group , Orr N 183 , Orsulic S 4 , Osorio A 31 , Palli D 184 , Papi L 185 , Park-Simon TW 119 , Paul J 186 , Pearce CL 113 , Pedersen IS 187 , Peeters PHM 182 , Peissel B 23 , Peixoto A 188 , Pejovic T 170 , Pelttari LM 140 , Permuth JB 1 , Peterlongo P 189 , Pezzani L 23 , Pfeiler G 190 , Phillips KA 191 , Piedmonte M 192 , Pike MC 113 , Piskorz AM 44 , Poblete SR 151 , Pocza T 178 , Poole EM 193 , Poppe B 63 , Porteous ME 194 , Prieur F 195 , Prokofyeva D 70 , Pugh E 14 , Pujana MA 196 , Pujol P 197 , Radice P 198 , Rantala J 199 , Rappaport-Fuerhauser C 190 , Rennert G 200 , Rhiem K 112 , Rice P 37 , Richardson A 201 , Robson M 202 , Rodriguez GC 203 , Rodríguez-Antona C 204 , Romm J 14 , Rookus MA 205 , Rossing MA 206 , Rothstein JH 162 , Rudolph A 59 , Runnebaum IB 82 , Salvesen HB 35 , Sandler DP 207 , Schoemaker MJ 138 , Senter L 208 , Setiawan VW 113 , Severi G 209 , Sharma P 210 , Shelford T 14 , Siddiqui N 211 , Side LE 212 , Sieh W 162 , Singer CF 190 , Sobol H 213 , Song H 3 , Southey MC 214 , Spurdle AB 9 , Stadler Z 202 , Steinemann D 215 , Stoppa-Lyonnet D 50 , Sucheston-Campbell LE 216 , Sukiennicki G 110 , Sutphen R 217 , Sutter C 218 , Swerdlow AJ 138 , Szabo CI 219 , Szafron L 71 , Tan YY 190 , Taylor JA 207 , Tea MK 190 , Teixeira MR 188 , Teo SH 220 , Terry KL 66 , Thompson PJ 221 , Thomsen LCV 35 , Thull DL 222 , Tihomirova L 223 , Tinker AV 224 , Tischkowitz M 94 , Tognazzo S 171 , Toland AE 225 , Tone A 33 , Trabert B 36 , Travis RC 226 , Trichopoulou A 227 , Tung N 228 , Tworoger SS 193 , van Altena AM 229 , Van Den Berg D 113 , van der Hout AH 230 , van der Luijt RB 231 , Van Heetvelde M 63 , Van Nieuwenhuysen E 232 , van Rensburg EJ 78 , Vanderstichele A 232 , Varon-Mateeva R 233 , Vega A 234 , Edwards DV 235 , Vergote I 232 , Vierkant RA 5 , Vijai J 173 , Vratimos A 93 , Walker L 236 , Walsh C 4 , Wand D 237 , Wang-Gohrke S 238 , Wappenschmidt B 112 , Webb PM 239 , Weinberg CR 240 , Weitzel JN 241 , Wentzensen N 36 , Whittemore AS 162 , Wijnen JT 242 , Wilkens LR 149 , Wolk A 114 , Woo M 128 , Wu X 118 , Wu AH 113 , Yang H 36 , Yannoukakos D 93 , Ziogas A 243 , Zorn KK 222 , Narod SA 244 , Easton DF 245 , Amos CI 246 , Schildkraut JM 247 , Ramus SJ 248 , Ottini L 249 , Goodman MT 221 , Park SK 250 , Kelemen LE 251 , Risch HA 252 , Thomassen M 143 , Offit K 173 , Simard J 11 , Schmutzler RK 112 , Hazelett D 253 , Monteiro AN 1 , Couch FJ 67 , Berchuck A 6 , Chenevix-Trench G 9 , Goode EL 7 , Sellers TA 1 , Gayther SA 8 , Antoniou AC 245 , Pharoah PDP 245

Affiliations 

  • 1 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA
  • 2 Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK
  • 3 Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
  • 4 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  • 5 Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA
  • 6 Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA
  • 7 Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
  • 8 Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  • 9 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
  • 10 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • 11 Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Quebec, Canada
  • 12 Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands
  • 13 Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, the Netherlands
  • 14 Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • 15 Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK
  • 16 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
  • 17 Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, School of Medicine, University of California-Irvine, Irvine, California, USA
  • 18 N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus
  • 19 'Agii Anargiri' Cancer Hospital, Athens, Greece
  • 20 Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany
  • 21 Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  • 22 Department of Oncology and Pathology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
  • 23 Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy
  • 24 Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain
  • 25 Gynaecology Unit, Royal Marsden Hospital, London, UK
  • 26 Bâtiment Cheney D, Centre Léon Bérard, Lyon, France
  • 27 Laboratory of Cell Biology, Department of Pathology, Landspitali, Reykjavik, Iceland
  • 28 Department of Gynecologic Oncology, Oregon Health &Science University, Portland, Oregon, USA
  • 29 Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany
  • 30 Division of Epidemiology, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, USA
  • 31 Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain
  • 32 Institute of Biochemistry and Genetics, Ufa Science Center, Russian Academy of Sciences, Ufa, Russian Federation
  • 33 Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
  • 34 Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
  • 35 Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
  • 36 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
  • 37 Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA
  • 38 Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands
  • 39 Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
  • 40 Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark
  • 41 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy
  • 42 Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden
  • 43 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
  • 44 Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK
  • 45 Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK
  • 46 Department of Cancer Epidemiology, University Hospital, Lund, Lund University, Lund, Sweden
  • 47 Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
  • 48 Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia
  • 49 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain
  • 50 Service de Génétique Oncologique, Institut Curie, Paris, France
  • 51 Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  • 52 Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA
  • 53 Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain
  • 54 Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy
  • 55 Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
  • 56 Cancer Pathology and Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA
  • 57 Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
  • 58 Cancer Risk Program, University of California, San Francisco, San Francisco, California, USA
  • 59 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 60 Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia
  • 61 Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Quebec City, Quebec, Canada
  • 62 Departments of Pediatrics and Medicine, Columbia University, New York, New York, USA
  • 63 Center for Medical Genetics, Ghent University, Ghent, Belgium
  • 64 Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA
  • 65 Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK
  • 66 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
  • 67 Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
  • 68 Social &Scientific Systems, Inc., Durham, North Carolina, USA
  • 69 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
  • 70 Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation
  • 71 Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
  • 72 Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  • 73 Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK
  • 74 Unité d'Oncogénétique, ICO-Centre René Gauducheau, Nantes, France
  • 75 Oncogenetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain
  • 76 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA
  • 77 Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
  • 78 Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Pretoria, South Africa
  • 79 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
  • 80 Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France
  • 81 Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain
  • 82 Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany
  • 83 Institute of Human Genetics, Münster, Germany
  • 84 University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK
  • 85 Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK
  • 86 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • 87 Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
  • 88 Department of Biostatistics and Bioinformatics, Roswell Park Institute, Buffalo, New York, USA
  • 89 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
  • 90 Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
  • 91 Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France
  • 92 Department of Surgery and Cancer, Imperial College London, London, UK
  • 93 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece
  • 94 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada
  • 95 Department of Medical Oncology, Papageorgiou, Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
  • 96 Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA
  • 97 Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute, Boston, Massachusetts, USA
  • 98 Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel
  • 99 Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, UCLA Schools of Medicine and Public Health, Los Angeles, California, USA
  • 100 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
  • 101 Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany
  • 102 Women's Cancer, Institute for Women's Health, University College London, London, UK
  • 103 Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • 104 Beatson West of Scotland Cancer Centre, Glasgow, UK
  • 105 Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
  • 106 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
  • 107 Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA
  • 108 Department of Medicine, Royal Marsden Hospital, London, UK
  • 109 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
  • 110 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
  • 111 Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
  • 112 Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany
  • 113 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
  • 114 Division of Nutritional Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  • 115 Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
  • 116 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • 117 Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK
  • 118 Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  • 119 Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
  • 120 Medical Genetics Unit, St George's University of London, London, UK
  • 121 Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • 122 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
  • 123 Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands
  • 124 Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands
  • 125 Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York, USA
  • 126 Center for Medical Genetics, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois, USA
  • 127 Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  • 128 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
  • 129 N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation
  • 130 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
  • 131 Department of Statistical Science, Duke University, Durham, North Carolina, USA
  • 132 Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK
  • 133 Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
  • 134 Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
  • 135 Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden
  • 136 Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
  • 137 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA
  • 138 Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK
  • 139 Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
  • 140 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
  • 141 Department of Surgery, Breast Care Center, Daerim St. Mary's Hospital, Seoul, Republic of Korea
  • 142 Department of Pathology, University of Calgary, Calgary, Alberta, Canada
  • 143 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
  • 144 Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong
  • 145 Vesalius Research Center, VIB, Leuven, Belgium
  • 146 Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia-San Sebastian, Spain
  • 147 Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain
  • 148 Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada
  • 149 Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
  • 150 Department of Surgery, Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea
  • 151 Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
  • 152 Département de Génétique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
  • 153 Institut Curie, PSL Research Unviersity and INSERM U900, Paris, France
  • 154 College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA
  • 155 Cancer Center Wolfsburg, Clinics of Gynaecology, Wolfsburg, Germany
  • 156 Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
  • 157 Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
  • 158 Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  • 159 Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • 160 INSERM U1052, CNRS UMR 5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France
  • 161 Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Vancouver General Hospital and BC Cancer Agency, Vancouver, British Columbia, Canada
  • 162 Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA
  • 163 Public Health Ontario, Toronto, Ontario, Canada
  • 164 Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK
  • 165 Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands
  • 166 Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
  • 167 Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands
  • 168 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
  • 169 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  • 170 Knight Cancer Institute, Oregon Health &Science University, Portland, Oregon, USA
  • 171 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
  • 172 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
  • 173 Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  • 174 Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • 175 University of Texas School of Public Health, Houston, Texas, USA
  • 176 Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • 177 Invitae Corporation, San Francisco, California, USA
  • 178 Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary
  • 179 Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA
  • 180 Department of Obstetrics and Gynecology, Ohio State University and the James Cancer Center, Columbus, Ohio, USA
  • 181 West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK
  • 182 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  • 183 Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK
  • 184 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy
  • 185 Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
  • 186 Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
  • 187 Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
  • 188 Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
  • 189 IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy
  • 190 Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria
  • 191 Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • 192 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA
  • 193 Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
  • 194 South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK
  • 195 Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France
  • 196 Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain
  • 197 Unité d'Oncogénétique, Centre Hospitalier Universitaire Arnaud de Villeneuve, Montpellier, France
  • 198 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy
  • 199 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
  • 200 Clalit National Israeli Cancer Control Center, Haifa, Israel
  • 201 Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
  • 202 Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  • 203 Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA
  • 204 Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain
  • 205 Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands
  • 206 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
  • 207 Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA
  • 208 Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
  • 209 Facultés de Médecin, Université Paris-Sud, Villejuif, France
  • 210 Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA
  • 211 Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK
  • 212 North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK
  • 213 Département Oncologie Génétique, Institut Paoli-Calmettes, Marseille, France
  • 214 Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
  • 215 Institute of Human Genetics, Hannover Medical School, Hannover, Germany
  • 216 Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA
  • 217 Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA
  • 218 Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany
  • 219 National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA
  • 220 Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
  • 221 Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  • 222 Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  • 223 Latvian Biomedical Research and Study Centre, Riga, Latvia
  • 224 Ovarian Cancer Research (OVCARE) Program-Cheryl Brown Ovarian Cancer Outcomes Unit (CBOCOU), BC Cancer Agency, Vancouver, British Columbia, Canada
  • 225 Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
  • 226 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
  • 227 Hellenic Health Foundation, Athens, Greece
  • 228 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
  • 229 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands
  • 230 Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
  • 231 Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands
  • 232 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
  • 233 Institute of Medical and Human Genetics, Charité Universitätsmedizin, Campus Virchov Klinikum, Berlin, Germany
  • 234 Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain
  • 235 Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt Medical School, Nashville, Tennessee, USA
  • 236 Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK
  • 237 Institute of Human Genetics, University Hospital, Leipzig, Germany
  • 238 Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
  • 239 Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
  • 240 Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA
  • 241 Clinical Cancer Genetics, City of Hope, Duarte, California, USA
  • 242 Departments of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands
  • 243 Department of Epidemiology, University of California-Irvine, Irvine, California, USA
  • 244 Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada
  • 245 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
  • 246 Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA
  • 247 Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
  • 248 School of Women's and Children's Health, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia
  • 249 Department of Molecular Medicine, University La Sapienza, Rome, Italy
  • 250 Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea
  • 251 Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
  • 252 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA
  • 253 Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA
Nat Genet, 2017 May;49(5):680-691.
PMID: 28346442 DOI: 10.1038/ng.3826

Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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