Chemical composition and cytotoxic activity of Garcinia atroviridis Griff. ex T. Anders. essential oils in combination with tamoxifen

Tan WN 1 , Lim JQ 2 , Afiqah F 2 , Nik Mohamed Kamal NNS 3 , Abdul Aziz FA 3 , Tong WY 4 Show all authors , Leong CR 4 , Lim JW 5

Affiliations 

  • 1 a School of Distance Education , Universiti Sains Malaysia , Penang , Malaysia
  • 2 b School of Chemical Sciences , Universiti Sains Malaysia , Penang , Malaysia
  • 3 c Cluster of Integrative Medicine, Advanced Medical and Dental Institute , Universiti Sains Malaysia , Penang , Malaysia
  • 4 d Section of Bioengineering Technology , Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology , Melaka , Malaysia
  • 5 e Department of Fundamental and Applied Sciences , Universiti Teknologi Petronas , Perak , Malaysia
Nat Prod Res, 2018 Apr;32(7):854-858.
PMID: 28782393 DOI: 10.1080/14786419.2017.1361951

Abstract

Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9%) and palmitic acid (21.9%), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5%) and β-caryophyllene (16.9%). Treatment of MCF-7 cells using EO-L (100 μg/mL) caused more than 50% cell death while EO-SB did not induce cytotoxic effect. EO-L has stimulated the growth of BEAS-2B normal cells, but not in MCF-7 cancerous cells. The IC50 of EO-L in MCF-7 and BEAS-2B cells were 71 and 95 μg/mL, respectively. A combination treatment of EO-L and tamoxifen induced more cell death than the treatment with drug alone at lower doses.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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