Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities

Tan WN 1 , Tan ZH 2 , Zulkifli NI 3 , Nik Mohamed Kamal NNS 3 , Rozman NAS 4 , Tong WY 4 Show all authors , Leong CR 4 , Lim JW 5

Affiliations 

  • 1 School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia
  • 2 School of Chemical Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 3 Cluster of Integrative Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, Malaysia
  • 4 Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology, Melaka, Malaysia
  • 5 Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, Perak, Malaysia
Nat Prod Res, 2020 Dec;34(23):3404-3408.
PMID: 30773054 DOI: 10.1080/14786419.2019.1569012

Abstract

Garcinia celebica L., locally known as "manggis hutan" in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25%), germacrene D (6.72%) and β-caryophyllene (5.85%). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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