Affiliations 

  • 1 School of Chemical Sciences, Universiti Sains Malaysia, Penang, Malaysia
  • 2 Molecular Entomology Research Group, School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia; Entomology Division, Cocoa Research Institute of Ghana, New Tafo-Akim, Ghana
  • 3 Molecular Entomology Research Group, School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia
  • 4 School of Chemical Sciences, Universiti Sains Malaysia, Penang, Malaysia. Electronic address: mohd.rizal@usm.my
J. Inorg. Biochem., 2017 10;175:232-238.
PMID: 28800547 DOI: 10.1016/j.jinorgbio.2017.07.030

Abstract

New synthesized bis-imidazolium salts that are linked by xylyl derivatives moiety, 1-4 was reacted with Ag2O to facilitate the formation of dinuclear Ag(I)-N-heterocyclic carbene (NHC) complexes, 5-8, respectively. All the synthesized ligand salts and complexes were characterized by1H and13C NMR, FTIR spectroscopy and elemental analysis. Molecular structures of compounds 3, 5, and 7 were elucidated by single crystal X-ray diffraction analyses. Larvicidal studies against the Aedes aegypti and Culex quinquefasciatus were carried out on all synthesized compounds following the World Health Organization standard larval susceptibility test. All the imidazolium salts were found inactive while the activity of the dinuclear Ag(I)-NHC complexes on mosquito larvae are varies with the nature of the ligands. Complex 7 has high activity on Ae. aegypti and Cx. quinquefasciatus, emphasising its potential as a larvicidal compound.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.