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Frequency and predictors of the lupus low disease activity state in a multi-national and multi-ethnic cohort

Golder V 1 , Kandane-Rathnayake R 2 , Hoi AY 2 , Huq M 3 , Louthrenoo W 4 , An Y 5 Show all authors , Li ZG 5 , Luo SF 6 , Sockalingam S 7 , Lau CS 8 , Lee AL 8 , Mok MY 8 , Lateef A 9 , Franklyn K 2 , Morton S 10 , Navarra ST 11 , Zamora L 11 , Wu YJ 6 , Hamijoyo L 12 , Chan M 13 , O'Neill S 14 , Goldblatt F 15 , Morand EF 2 , Nikpour M 3 , Asia-Pacific Lupus Collaboration

Affiliations 

  • 1 Monash University, Melbourne, Australia. vera.golder@monash.edu
  • 2 Monash University, Melbourne, Australia
  • 3 The University of Melbourne, Melbourne, Australia
  • 4 Chiang Mai University Hospital, Chiang Mai, Thailand
  • 5 People's Hospital Peking University Health Sciences Center, Beijing, China
  • 6 Chang Gung Memorial Hospital, Guishan Township, Taiwan
  • 7 University of Malaya, Kuala Lumpur, Malaysia
  • 8 University of Hong Kong, Hong Kong, Hong Kong
  • 9 National University Hospital, Singapore, Singapore
  • 10 Monash Health, Melbourne, Australia
  • 11 University of Santo Tomas Hospital, Manila, Philippines
  • 12 University of Padjadjaran, Bandung, Indonesia
  • 13 Tan Tock Seng Hospital, Singapore, Singapore
  • 14 University of New South Wales, Sydney, Australia
  • 15 Royal Adelaide Hospital, Adelaide, Australia
Arthritis Res Ther, 2016 11 09;18(1):260.
PMID: 27829463 DOI: 10.1186/s13075-016-1163-2

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity state (LLDAS) has been recently reported, with retrospective validation showing that time spent in LLDAS translates to reduced damage accrual. The objectives of this study were to describe the frequency and identify the predictors of attaining LLDAS in a large multinational cohort of patients with SLE.
METHODS: Data were collected at the recruitment visit in patients with SLE enrolled in a longitudinal study in nine countries. Data were analysed cross-sectionally against the recently published definition of LLDAS, and the frequency and characteristics associated with presence of LLDAS were determined. Stepwise multivariable logistic regression was used to determine predictors of LLDAS.
RESULTS: Of the 1846 patients assessed, criteria for LLDAS were met by 44 %. Patients with shorter disease duration were less likely to be in LLDAS (OR 0.31, 95 % CI 0.19-0.49, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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