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Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study

Golder V 1 , Kandane-Rathnayake R 2 , Hoi AY 2 , Huq M 3 , Louthrenoo W 4 , An Y 5 Show all authors , Li ZG 5 , Luo SF 6 , Sockalingam S 7 , Lau CS 8 , Mok MY 8 , Lateef A 9 , Franklyn K 2 , Morton S 10 , Navarra ST 11 , Zamora L 11 , Wu YJ 6 , Hamijoyo L 12 , Chan M 13 , O'Neill S 14 , Goldblatt F 15 , Nikpour M 3 , Morand EF 2 , Asia-Pacific Lupus Collaboration

Affiliations 

  • 1 Monash University School of Clinical Sciences at Monash Health, Level 5, Block E, Monash Medical Centre, 246 Clayton Road, Clayton, VIC, 3168, Melbourne, Australia. vera.golder@monash.edu
  • 2 Monash University School of Clinical Sciences at Monash Health, Level 5, Block E, Monash Medical Centre, 246 Clayton Road, Clayton, VIC, 3168, Melbourne, Australia
  • 3 The University of Melbourne, Melbourne, Australia
  • 4 Chiang Mai University Hospital, Chiang Mai, Thailand
  • 5 People's Hospital Peking University Health Sciences Center, Beijing, China
  • 6 Chang Gung Memorial Hospital, Guishan Township, Taiwan
  • 7 University of Malaya, Kuala Lumpur, Malaysia
  • 8 University of Hong Kong, Pokfulam, Hong Kong
  • 9 National University Hospital, Singapore, Republic of Singapore
  • 10 Monash Health, Melbourne, Australia
  • 11 University of Santo Tomas Hospital, Manila, Philippines
  • 12 University of Padjadjaran, Bandung, Indonesia
  • 13 Tan Tock Seng Hospital, Singapore, Republic of Singapore
  • 14 University of New South Wales, Sydney, Australia
  • 15 Royal Adelaide Hospital, Adelaide, Australia
Arthritis Res Ther, 2017 03 20;19(1):62.
PMID: 28320433 DOI: 10.1186/s13075-017-1256-6

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as associated with protection from damage accrual. The LLDAS definition has not been previously evaluated for association with patient-reported outcomes. The objective of this study was to determine whether LLDAS is associated with better HR-QoL, and examine predictors of HR-QoL, in a large multiethnic, multinational cohort of patients with SLE.
METHODS: HR-QoL was measured using the Medical Outcomes Study 36-item short form health survey (SF-36v2) in a prospective study of 1422 patients. Disease status was measured using the SLE disease activity index (SLEDAI-2 K), physician global assessment (PGA) and LLDAS.
RESULTS: Significant differences in SF-36 domain scores were found between patients stratified by ethnic group, education level and damage score, and with the presence of active musculoskeletal or cutaneous manifestations. In multiple linear regression analysis, Asian ethnicity (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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