12-Epi-9-deacetoxyxenicin, new cytotoxic diterpenoid from a Bornean soft coral, Xenia sp

Phan CS 1 , Kamada T 1 , Ishii T 2 , Hamada T 3 , Vairappan CS 1

Affiliations 

  • 1 a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti Malaysia Sabah , Kota Kinabalu , Malaysia
  • 2 b Faculty of Agriculture, Department of Bioscience and Biotechnology , University of the Ryukyus , Nishihara , Japan
  • 3 c Graduate School of Science and Engineering , Kagoshima University , Kagoshima , Japan
Nat Prod Res, 2019 Mar;33(6):808-813.
PMID: 29202596 DOI: 10.1080/14786419.2017.1410812

Abstract

One new compound, 12-epi-9-deacetoxyxenicin (1) along with a hydroperoxide product, 12-epi-9-deacetoxy-8-hydroperoxyxenicin (2) and two known sesquiterpenoids (3-4) were isolated from a population of Bornean soft coral Xenia sp. The structures of these secondary metabolites were elucidated based on their spectroscopic data. Compounds 1 and 2 showed cytotoxic activity against ATL cell line, S1T. In addition, compound 3 exhibited hyphal inhibition of Lagenidium thermophilum.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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