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MiR-3099 is Overexpressed in Differentiating 46c Mouse Embryonic Stem Cells upon Neural Induction

Zainal Abidin S 1 , Abbaspourbabaei M 1 , Ntimi CM 1 , Siew WH 1 , Pike-See C 2 , Rosli R 1 Show all authors , Nordin N 1 , Ling KH 1

Affiliations 

  • 1 Genetics and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor, Malaysia ; Clinical Genetics Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor, Malaysia
  • 2 Genetics and Regenerative Medicine Research Centre, Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor, Malaysia
Malays J Med Sci, 2014 Dec;21(Spec Issue):27-33.
PMID: 25941460 MyJurnal

Abstract

MicroRNAs (miRNAs) have a crucial role in gene expression regulation and protein synthesis, especially in the central nervous system. In developing mouse embryos a novel miRNA, miR-3099, is highly expressed, particularly in the central nervous system. This study aims to determine the expression of miR-3099 during cellular differentiation of 46C mouse embryonic stem cells after neural induction with N2/B27 medium.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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