• 1 International Islamic University Malaysia


Over accumulation of polyamines is one of the causes of cancer because
polyamines could promote the cancer cells growth. Due to the lack of specificity and
increased reports of side effects in the current cancer treatment, one of the strategies
to overcome the challenges is by utilizing polyamines as vectors of known cytotoxic
compounds to target the cancer cells. Therefore, this study was aimed to investigate
the cytotoxicity effect of Spermidine Sulphur Analogues Type 1 and Type 2 (SSA-1 and
SSA-2) against human lung adenocarcinoma cells (A549), human colorectal
adenocarcinoma cells (HCT-8) and human breast adenocarcinoma cell (MCF-7). (Copied from article).