Cancer is one of the global health problems that has a detrimental effect
to a person's life. However, chemotherapeutic agents success are subject to the side
effects due to lack of specificity in the drug delivery system to cancer cells and an
increase risk of systemic toxicity to the normal cells. Polyamine transport system (PTS)
is one of the potential pathways for transporting anticancer agent into specific cancer
cells. This is due to the upregulation of PTS in cancer cells compared to normal cells for
the proliferation activity. The aim of this study was to investigate the cytotoxicity effect
of putrescine-sulphur analogues type 1 (PSA-1) and type 2 (PSA-2) on human lung
adenocarcinoma cells (A549), human colorectal adenocarcinoma cells (HCT-8) and
human breast adenocarcinoma cell (MCF-7).