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Cranial neural tube defect after trimethoprim exposure

Abdullah NL 1 , Gunasekaran R 1 , Mohd-Zin SW 1 , Lim BH 1 , Maniam P 1 , Mohd-Salleh AS 1 Show all authors , Thong MK 2 , Chik Z 3 , Nordin N 4 , Omar Z 5 , Engkasan JP 5 , Ganesan D 6 , Aiezzah ZN 1 , Ahmad-Annuar A 7 , Abdul-Aziz NM 8

Affiliations 

  • 1 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 Department of Paediatrics, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 3 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Department of Pharmacology, Faculty of Medicine, University of Malaya Bioequivalence and Testing Centre (UBAT), University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 5 Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 6 Department of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 7 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 8 Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. noisha@ummc.edu.my
BMC Res Notes, 2018 Jul 16;11(1):475.
PMID: 30012199 DOI: 10.1186/s13104-018-3593-1

Abstract

OBJECTIVES: The Neural Tube Defects Research Group of University of Malaya was approached to analyze a tablet named TELSE, which may have resulted in a baby born with central nervous system malformation at the University of Malaya Medical Centre. In this animal experimental study, we investigated the content of TELSE and exposure of its contents that resulted in failure of primary neurulation.

RESULTS: Liquid Chromatography Tandem Mass spectrophotometry analysis of the TELSE tablet confirmed the presence of trimethoprim as the active compound. The TELSE tablet-treated females produced significant numbers of embryos with exencephaly (n = 8, 36.4%, *P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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