Modern science has found that most traditional practice of using stingless bee honey has
great potential as an added value in modern medicine and considered to have a higher
medicinal value than other bee species. However, due to the relatively low output of honey
compared to other honey so, focus on this honey is limited. Hence, this systematic review
provides the updated result on the potential value of stingless bee honey as an antioxidant,
anti-inflammatory, cytotoxicity and antimicrobial. The search strategy was developed in
four databases (Scopus, Medline and Ovid, EMBASE and PubMed) with the search terms
"("honey" and "Kelulut", "honey" and "stingless bee", "honey" and "Trigona", "honey"
and "pot honey", and "honey" and "Melipon")". The merged data was assessed using
PRISMA guidelines and after the duplicates were removed, 1271 articles were segregated.
Afterwards, 1232 articles were eliminated because they do not meet the inclusion criteria
and 39 articles were reevaluated again for eligibility. Finally, after the evaluation process,
only 26 of the articles were chosen for this review. The data of 26 articles of stingless bee
honey were deliberated based on antioxidant properties, anti-inflammatory, cytotoxicity
and analysis of antimicrobial activity. Three articles reported on antioxidant properties,
one article on anti-inflammatory analysis, two articles on cytotoxicity analysis, and twenty
articles on analysis of antimicrobial activity. Based on the feasible affirmation from the
literature, stingless bee honey has an antioxidant capacity that able to decrease the ROS.
ROS able to lead a variety of health problems thus stingless bee honey can be a dietary
supplement to overcome this problem.