O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

George S 1 , Ajikumaran Nair S 1 , Johnson AJ 1 , Venkataraman R 2 , Baby S 3

Affiliations 

  • 1 Phytochemistry and Phytopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Pacha-Palode, Thiruvananthapuram 695 562, Kerala, India
  • 2 Department of Chemistry, Sri Paramakalyani College (Manonmaniam Sundaranar University, Tirunelveli), Alwarkurichi 627 412, Tamil Nadu, India
  • 3 Phytochemistry and Phytopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Pacha-Palode, Thiruvananthapuram 695 562, Kerala, India. Electronic address: sabulal@gmail.com
J Ethnopharmacol, 2015 Jun 20;168:158-63.
PMID: 25858510 DOI: 10.1016/j.jep.2015.03.060

Abstract

Melicope lunu-ankenda leaves are used to treat diabetes in folklore medicinal practices in India and Malaysia. Here we report the isolation of an O-prenylated flavonoid (3,5,4'-trihydroxy-8,3'-dimethoxy-7-(3-methylbut-2-enoxy)flavone; OPF) from the leaves of M. lunu-ankenda and its antidiabetes activity against type-2 diabetes mellitus (T2DM).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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