Affiliations 

  • 1 Department of Neurosciences, Universiti Sains Malaysia, Malaysia
  • 2 Department of Microbiology, Universiti Sains Malaysia, Malaysia
  • 3 Unit of Biostatistics and Research Methodology, Universiti Sains Malaysia, Malaysia
  • 4 Department of Forensic and Pathology, Kuala Lumpur Hospital, Malaysia
  • 5 Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', Mexico
  • 6 Department of Neurosciences, Universiti Sains Malaysia, Malaysia. Electronic address: brainsciences@gmail.com
  • 7 Department of Pathology, University Sains Malaysia, Malaysia. Electronic address: hasnan@usm.my
Tuberculosis (Edinb), 2018 09;112:45-51.
PMID: 30205968 DOI: 10.1016/j.tube.2018.07.007

Abstract

The present study aimed to investigate the involvement of the angiogenic marker vascular endothelia growth factor (VEGF) and apoptotic markers of Bcl-2 and Bax in the neurons and astrocytes in the brain infected by Mycobacterium tuberculosis. The immunohistochemistry staining was performed to analyze the expression of the VEGF, Bcl-2 and Bax in the astrocytes and neurons. The expression of VEGF was high in neurons and astrocytes in both the infected brain and control tissues with no difference of angiogenic activity (p = 0.40). Higher Bcl-2 expression was seen in astrocytes of infected brain tissues compared to the control tissues (p = 0.004) promoted a higher anti-apoptotic activity in astrocytes. The neurons expressed strong Bax expression in the infected brain tissues compared to the control tissues (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.