In vitro evaluation of Cuscuta reflexa Roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities

Azad AK 1 , Laboni FR 2 , Rashid H 2 , Ferdous S 3 , Rashid SS 4 , Kamal N 5 Show all authors , Labu ZK 2 , Islam MS 6 , Islam Sarker Z 1

Affiliations 

  • 1 Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • 2 Department of Pharmacy, World University of Bangladesh, Dhaka, Bangladesh
  • 3 Faculty of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • 4 Faculty of Industrial Science and Technology, University Malaysia Pahang, Gambang, Pahang, Malaysia
  • 5 Faculty of Pharmacy, Cyberjaya University College of Medical Sciences, Cyberjaya, Selangor, Malaysia
  • 6 Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Nat Prod Res, 2020 Aug;34(16):2394-2397.
PMID: 30475649 DOI: 10.1080/14786419.2018.1538216

Abstract

The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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