Antidiarrheal, antimicrobial and antioxidant potentials of methanol extract of Colocasia gigantea Hook. f. leaves: evidenced from in vivo and in vitro studies along with computer-aided approaches

Alam S; Rashid MA; Sarker MMR; Emon NU; Arman M; Mohamed IN; Haque MR

doi:10.1186/s12906-021-03290-6

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Antidiarrheal, antimicrobial and antioxidant potentials of methanol extract of Colocasia gigantea Hook. f. leaves: evidenced from in vivo and in vitro studies along with computer-aided approaches

Alam S ¹ , Rashid MA ¹ , Sarker MMR ² , Emon NU ³ , Arman M ⁴ , Mohamed IN ⁵ Show all authors , Haque MR ⁶

Affiliations

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh
² Department of Pharmacy, State University of Bangladesh, 77 Satmasjid road, Dhanmondi, Dhaka, 1207, Bangladesh
³ Department of Public Health, School of Science and Technology, Bangladesh Open University, Gazipur, Dhaka, 1705, Bangladesh
⁴ Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh
⁵ Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia (The National University of Malaysia), Cheras, Malaysia. isanaina@yahoo.co.uk
⁶ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh. haquemr@du.ac.bd

BMC Complement Med Ther, 2021 Apr 12;21(1):119.

PMID: 33845836 DOI: 10.1186/s12906-021-03290-6

Abstract

BACKGROUND: Colocasia gigantea, locally named as kochu is well-known due to its various healing power. This research is to investigate the antidiarrheal, antimicrobial and antioxidant possibilities of the methanol soluble extract of Colocasia gigantea.

METHODS: The antidiarrheal investigation was performed by using in vivo castor oil-induced diarrheal method whereas in vitro antimicrobial and antioxidant investigation have been implemented by disc diffusion and DPPH scavenging method respectively. Moreover, in silico studies were followed by molecular docking analysis of several secondary metabolites that were appraised with Schrödinger-Maestro v11.1 and Biovia Discovery Studio.

RESULTS: The induction of plant extract (200 and 400 mg/kg, b.w, p.o) has minimized the castor oil mediated diarrhea by 16.96% (p

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.