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Targeting myomiRs by tocotrienol-rich fraction to promote myoblast differentiation

Razak AM 1 , Khor SC 1 , Jaafar F 1 , Karim NA 1 , Makpol S 1

Affiliations 

  • 1 Department of Biochemistry, Faculty of Medicine, Level 17, Preclinical Building, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Jalan Yaakob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
Genes Nutr, 2018;13:31.
PMID: 30519366 DOI: 10.1186/s12263-018-0618-2

Abstract

Background: Several muscle-specific microRNAs (myomiRs) are differentially expressed during cellular senescence. However, the role of dietary compounds on myomiRs remains elusive. This study aimed to elucidate the modulatory role of tocotrienol-rich fraction (TRF) on myomiRs and myogenic genes during differentiation of human myoblasts. Young and senescent human skeletal muscle myoblasts (HSMM) were treated with 50 μg/mL TRF for 24 h before and after inducing differentiation.

Results: The fusion index and myotube surface area were higher (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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