Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathways

Foo SC; Yusoff FM; Imam MU; Foo JB; Ismail N; Azmi NH; Tor YS; Khong NMH; Ismail M

doi:10.1016/j.btre.2018.e00296

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Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathways

Foo SC ¹ , Yusoff FM ¹ , Imam MU ¹ , Foo JB ¹ , Ismail N ¹ , Azmi NH ¹ Show all authors , Tor YS ¹ , Khong NMH ¹ , Ismail M ¹

Affiliations

¹ Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor Darul Ehsan, Malaysia

Biotechnol Rep (Amst), 2019 Mar;21:e00296.

PMID: 30581767 DOI: 10.1016/j.btre.2018.e00296

Abstract

In this study, anti-proliferative effects of C. calcitrans extract and its fucoxanthin rich fraction (FxRF) were assessed on human liver HepG2 cancer cell line. Efficacy from each extract was determined by cytotoxicity assay, morphological observation, and cell cycle analysis. Mechanisms of action observed were evaluated using multiplex gene expression analysis. Results showed that CME and FxRF induced cytotoxicity to HepG2 cells in a dose and time-dependent manner. FxRF (IC50: 18.89 μg.mL-1) was found to be significantly more potent than CME (IC50: 87.5 μg.mL-1) (p

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