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Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways

Foo JB , Yazan LS 1 , Tor YS , Armania N , Ismail N , Imam MU Show all authors , Yeap SK , Cheah YK , Abdullah R , Ismail M

Affiliations 

  • 1 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. latifahsy@upm.edu.my
BMC Complement Altern Med, 2014;14:197.
PMID: 24947113 DOI: 10.1186/1472-6882-14-197

Abstract

Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient MCF-7 breast cancer cells.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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