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Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

Zhang XC 1 , Wang J 2 , Shao GG 3 , Wang Q 4 , Qu X 5 , Wang B 5 Show all authors , Moy C 6 , Fan Y 5 , Albertyn Z 7 , Huang X 5 , Zhang J 5 , Qiu Y 5 , Platero S 6 , Lorenzi MV 6 , Zudaire E 6 , Yang J 5 , Cheng Y 8 , Xu L 9 , Wu YL 10

Affiliations 

  • 1 Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, 510080, Guangzhou, China
  • 2 Peking University People's Hospital, Beijing, 100044, China
  • 3 Thoracic Surgery, 1st Hospital of Jilin University, 130021, Changchun, China
  • 4 Zhongshan Hospital, Fudan University, 200032, Shanghai, China
  • 5 Janssen R&D China, 355 Hong Qiao Road, 200030, Shanghai, China
  • 6 Janssen R&D, 1400 McKean Road, Spring House, Pennsylvania, 19002, USA
  • 7 Novocraft Technologies, 46300, Petaling Jaya, Selangor, Malaysia
  • 8 Department of Medical Oncology, Jilin Provincial Cancer Hospital, 130012, Changchun, China
  • 9 Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, 210009, Nanjing, China
  • 10 Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, 510080, Guangzhou, China. syylwu@live.cn
Nat Commun, 2019 04 16;10(1):1772.
PMID: 30992440 DOI: 10.1038/s41467-019-09762-1

Abstract

Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell signatures is found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared with squamous cell carcinoma (SQCC, 54.4%). The correlation of genomic alterations with immune signatures reveals that low immune infiltration was associated with EGFR mutations in ADC samples, PI3K and/or WNT pathway activation in SQCC. While KRAS mutations are found to be significantly associated with T cell infiltration in ADC samples. The SQCC patients with high antigen presentation machinery and cytotoxic T cell signature scores are found to have a prolonged overall survival time.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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