Screening for drugs of abused were conducted by using Gas chromatography-Mass spectrometry (GCMS) fitted with capillary column. Urine samples supplied by Centre of Inmigrant Studies, University of Malaya were processed upon arrival and screened for the following drugs. Amphetamines, methamphetamines, aphedrine, hydroxy-amphetamines, ecstasy, benzamphetamines, codeine, morphine, heroine, cocaine and diazepam. The analysis was done using Shimadzu QP5000 Gas chromatograph-mass spectrometer by selected ion monitoring with BPX35 column, 15 m length, 0.32 ID, helium gas as carrier and quadropole mass detector at 1.60 kV electron gain. Analysis were performed using selected ion monitoring (SIM) mode and quantitations were based on area under the curve of individual standards at various concentrations. The method is sensitive to nanogram levels and are able to detect the presence of these drugs in both urine and plasma. From this study (n-100), none of the urine were found positive for the drugs screened. The major problem encountered were adulterated with water based on the clearness and the colour of the urine. Based on this suspicion we would like to suggest that the testing be done on blood samples as this would be more confirmative and quantitative.