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Virucidal activity of Garcinia parvifolia leaf extracts in animal cell culture

Adnan A 1 , Allaudin ZN 2 , Hani H 3 , Loh HS 4 , Khoo TJ 5 , Ting KN 5 Show all authors , Abdullah R 6

Affiliations 

  • 1 Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
  • 2 Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. zeenathulnazariah@gmail.com
  • 3 Department of Cell Biology and Physiology, School of Medicine, University North Carolina, Chapel Hill, NC, 27599, USA
  • 4 School of Biosciences, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia
  • 5 School of Pharmacy, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia
  • 6 Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
BMC Complement Altern Med, 2019 Jul 10;19(1):169.
PMID: 31291936 DOI: 10.1186/s12906-019-2586-5

Abstract

BACKGROUND: Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of these compounds show interesting biological properties such as anti-human immunodeficiency virus activity. Garcinia parvifolia is used in traditional medicine. Currently, the antiviral activity of G. parvifolia is not known.

METHODS: This study was conducted to determine the effects of ethyl acetate (45 L Ea), ethanol (45 L Et), and hexane (45 L H) leaf extracts of G. parvifolia on the infectivity of pseudorabies virus (PrV) in Vero cells. The antiviral effects of the extracts were determined by cytopathic effect (CPE), inhibition, attachment, and virucidal assays.

RESULTS: The 50% cytotoxicity concentration (CC50) values obtained were 237.5, 555.0, and 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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