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Comparative assessment of faecal microbial composition and metabonome of swine, farmers and human control

Tan SC 1 , Chong CW 2 , Yap IKS 3 , Thong KL 4 , Teh CSJ 5

Affiliations 

  • 1 Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Malaysia
  • 3 Sarawak Research and Development Council, 11th Floor LCDA Tower, The Isthmus, Off Jalan Bako, 93050, Kuching, Sarawak, Malaysia
  • 4 NANOCAT Research Centre, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 5 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. cindysjteh@um.edu.my
Sci Rep, 2020 Jun 02;10(1):8997.
PMID: 32488118 DOI: 10.1038/s41598-020-65891-4

Abstract

The gastrointestinal tract of humans and swine consist of a wide range of bacteria which interact with hosts metabolism. Due to the differences in co-evolution and co-adaptation, a large fraction of the gut microbiome is host-specific. In this study, we evaluated the effect of close human-animal interaction to the faecal metagenome and metabonome of swine, farmer and human control. Three distinct clusters were observed based on T-RFLP-derived faecal microbial composition. However, 16S-inferred faecal microbiota and metabolic profiles showed that only human control was significantly different from the swine (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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