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Future Directions for Dementia Risk Reduction and Prevention Research: An International Research Network on Dementia Prevention Consensus

Anstey KJ 1 , Peters R 1 , Zheng L 1 , Barnes DE 2 , Brayne C 3 , Brodaty H 4 Show all authors , Chalmers J 5 , Clare L 6 , Dixon RA 7 , Dodge H 8 , Lautenschlager NT 9 , Middleton LE 10 , Qiu C 11 , Rees G 12 , Shahar S 13 , Yaffe K 2

Affiliations 

  • 1 UNSW Aging Futures Institute, School of Psychology, University of New South Wales, Sydney, NSW, Australia
  • 2 Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA
  • 3 Cambridge Public Health, University of Cambridge, Forvie Site, Cambridge, UK
  • 4 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
  • 5 Faculty of Medicine, The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia
  • 6 College of Medicine and Health, University of Exeter, St Luke's Campus, Exeter, UK
  • 7 Neuroscience and Mental Health Institute, Department of Psychology, University of Alberta, Edmonton, AB, Canada
  • 8 Layton Aging and Alzheimer's Disease Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA
  • 9 Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia
  • 10 Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada
  • 11 Aging Research Center and Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden
  • 12 Alzheimer's Disease International, London, UK
  • 13 Center for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
J Alzheimers Dis, 2020;78(1):3-12.
PMID: 32925063 DOI: 10.3233/JAD-200674

Abstract

In the past decade a large body of evidence has accumulated on risk factors for dementia, primarily from Europe and North America. Drawing on recent integrative reviews and a consensus workshop, the International Research Network on Dementia Prevention developed a consensus statement on priorities for future research. Significant gaps in geographical location, representativeness, diversity, duration, mechanisms, and research on combinations of risk factors were identified. Future research to inform dementia risk reduction should fill gaps in the evidence base, take a life-course, multi-domain approach, and inform population health approaches that improve the brain-health of whole communities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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