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Van Asbroeck S 1 , Köhler S 1 , van Boxtel MPJ 1 , Lipnicki DM 2 , Crawford JD 2 , Castro-Costa E 3 Show all authors , Lima-Costa MF 3 , Blay SL 4 , Shifu X 5 , Wang T 5 , Yue L 5 , Lipton RB 6 , Katz MJ 6 , Derby CA 6 , Guerchet M 7 , Preux PM 7 , Mbelesso P 8 , Norton J 9 , Ritchie K 9 , Skoog I 10 , Najar J 10 , Sterner TR 10 , Scarmeas N 11 , Yannakoulia M 12 , Dardiotis T 13 , Rolandi E 14 , Davin A 14 , Rossi M 14 , Gureje O 15 , Ojagbemi A 16 , Bello T 16 , Kim KW 17 , Han JW 17 , Oh DJ 18 , Trompet S 19 , Gussekloo J 19 , Riedel-Heller SG 20 , Röhr S 20 , Pabst A 20 , Shahar S 21 , Rivan NFM 21 , Singh DKA 21 , Jacobsen E 22 , Ganguli M 22 , Hughes T 23 , Haan M 24 , Aiello AE 25 , Ding D 26 , Zhao Q 26 , Xiao Z 26 , Narazaki K 27 , Chen T 28 , Chen S 29 , Ng TP 30 , Gwee X 30 , Gao Q 30 , Brodaty H 2 , Trollor J 2 , Kochan N 2 , Lobo A 31 , Santabárbara J 32 , Gracia-Garcia P 31 , Sachdev PS 2 , Deckers K 1 , for Cohort Studies of Memory in an International Consortium (COSMIC)

Affiliations 

  • 1 Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands
  • 2 Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia
  • 3 René Rachou Institute, Fiocruz Minas, Belo Horizonte, Minas Gerais, Brazil
  • 4 Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil
  • 5 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • 6 Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
  • 7 Inserm U1094, IRD UMR270, University Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France
  • 8 Department of Neurology, Amitié Hospital, Bangui, Central African Republic
  • 9 Institute for Neurosciences of Montpellier (INM), University of Montpellier, Inserm, Montpellier, France
  • 10 Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy, at the University of Gothenburg, Gothenburg, Sweden
  • 11 1st Department of Neurology, Aiginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  • 12 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
  • 13 School of Medicine, University of Thessaly, Larissa, Greece
  • 14 Golgi Cenci Foundation, Milan, Italy
  • 15 Department of Psychiatry, WHO Collaborating Centre for Research and Training in Mental Health, Neuroscience and Substance Abuse, University of Ibadan, Ibadan, Nigeria
  • 16 Department of Psychiatry, College of Medicine University of Ibadan, Ibadan, Nigeria
  • 17 Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • 18 Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • 19 Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
  • 20 Institute of Social Medicine, Occupational Health and Public Health, Medical Faculty, University of Leipzig, Leipzig, Germany
  • 21 Center for Healthy Ageing & Wellness (H-CARE), Faculty of Health Sciences, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 22 Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  • 23 Department of Graduate Studies in Health and Rehabilitation Sciences, Bitonte College of Health and Human Services, Youngstown State University, Youngstown, Ohio, USA
  • 24 Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, USA
  • 25 Columbia Aging Center and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
  • 26 Institute of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
  • 27 Center for Liberal Arts, Fukuoka Institute of Technology, Higashi-ku, Fukuoka, Japan
  • 28 Department of Physical Education, Sports and Health Research Center, Tongji University, Shanghai, China
  • 29 Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  • 30 Department of Psychological Medicine, Gerontology Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • 31 Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain
  • 32 Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain
Alzheimers Dement, 2024 Apr 27.
PMID: 38676366 DOI: 10.1002/alz.13846

Abstract

INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.

METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.

RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed.

DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.

HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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