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Dose-response relationship between late-life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium

Wu W 1 , Ding D 1 , Zhao Q 1 , Xiao Z 1 , Luo J 2 , Ganguli M 3 Show all authors , Hughes TF 4 , Jacobsen E 3 , Haan MN 5 , van Dang K 5 , Lima-Costa MF 6 , Blay SL 7 , de Castro-Costa E 6 , Ng TP 8 , Gwee X 8 , Gao Q 9 , Gureje O 10 , Ojagbemi A 10 , Bello T 10 , Shahar S 11 , Ludin AFM 12 , Rivan NFM 13 , Scarmeas N 14 , Anastasiou CA 15 , Yannakoulia M 15 , Brodaty H 16 , Crawford JD 16 , Lipton RB 17 , Derby CA 17 , Katz MJ 17 , Lipnicki DM 16 , Sachdev PS 16 , for Cohort Studies of Memory in an International Consortium (COSMIC)

Affiliations 

  • 1 Institute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China
  • 2 Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China
  • 3 Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  • 4 Department of Health Professions, Youngstown State University, Youngstown, Ohio, USA
  • 5 Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, USA
  • 6 Center for Studies in Public Health and Aging René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Brazil
  • 7 Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil
  • 8 Department of Psychological Medicine, National University of Singapore, Singapore, Singapore
  • 9 National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore, Singapore
  • 10 Department of Psychiatry, University of Ibadan, Ibadan, Nigeria
  • 11 Dietetic Program, Centre for Healthy Aging, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 12 Biomedical Science Program, Centre for Healthy Aging, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 13 Nutritional Sciences Program, Centre for Healthy Aging, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 14 Department of Neurology, Columbia University, New York, New York, USA
  • 15 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
  • 16 Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia
  • 17 Department of Neurology, Albert Einstein College of Medicine, New York, New York, USA
Alzheimers Dement, 2023 Jan;19(1):107-122.
PMID: 35290713 DOI: 10.1002/alz.12628

Abstract

INTRODUCTION: Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.

METHODS: We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.

RESULTS: Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).

DISCUSSION: This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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