Fulltext

Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

Röhr S 1 , Pabst A 2 , Riedel-Heller SG 2 , Jessen F 3 , Turana Y 4 , Handajani YS 5 Show all authors , Brayne C 6 , Matthews FE 7 , Stephan BCM 8 , Lipton RB 9 , Katz MJ 9 , Wang C 10 , Guerchet M 11 , Preux PM 11 , Mbelesso P 11 , Ritchie K 12 , Ancelin ML 12 , Carrière I 12 , Guaita A 13 , Davin A 13 , Vaccaro R 13 , Kim KW 14 , Han JW 14 , Suh SW 15 , Shahar S 16 , Din NC 17 , Vanoh D 18 , van Boxtel M 19 , Köhler S 19 , Ganguli M 20 , Jacobsen EP 20 , Snitz BE 21 , Anstey KJ 22 , Cherbuin N 23 , Kumagai S 24 , Chen S 25 , Narazaki K 26 , Ng TP 27 , Gao Q 27 , Gwee X 27 , Brodaty H 28 , Kochan NA 28 , Trollor J 28 , Lobo A 29 , López-Antón R 29 , Santabárbara J 29 , Crawford JD 28 , Lipnicki DM 28 , Sachdev PS 28 , for Cohort Studies of Memory in an International Consortium (COSMIC)

Affiliations 

  • 1 Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany. susanne.roehr@medizin.uni-leipzig.de
  • 2 Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany
  • 3 Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany
  • 4 Department of Neurology, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • 5 Center for Health Research, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • 6 Cambridge Public Health, Cambridge University, Cambridge, UK
  • 7 MRC Biostatistics Unit, Institute of Public Health, Cambridge University, Cambridge, UK
  • 8 Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
  • 9 Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA
  • 10 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA
  • 11 INSERM, U1094, Tropical Neuroepidemiology, Limoges, France
  • 12 INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France
  • 13 Golgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy
  • 14 Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • 15 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
  • 16 Centre of Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 17 Centre for Rehabilitation Science and Special Needs, Faculty of Health Science, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 18 School of Health Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia
  • 19 Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands
  • 20 Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  • 21 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  • 22 Ageing Futures Institute, University of New South Wales, Sydney, NSW, Australia
  • 23 Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, Australian National University, Canberra, ACT, Australia
  • 24 Center for Health Science and Counseling, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan
  • 25 Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
  • 26 Faculty of Socio-Environmental Studies, Department of Socio-Environmental Studies, Fukuoka Institute of Technology, 3-30-1 Wajiro-higashi, Higashi-ku, Fukuoka, 811-0295, Japan
  • 27 Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • 28 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia
  • 29 Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain
Alzheimers Res Ther, 2020 12 18;12(1):167.
PMID: 33339532 DOI: 10.1186/s13195-020-00734-y

Abstract

BACKGROUND: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts.

METHODS: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence.

RESULTS: The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades.

CONCLUSIONS: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications